AU2016303614A1 - Methods of preparing 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diols and 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diamines - Google Patents
Methods of preparing 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diols and 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diamines Download PDFInfo
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- AU2016303614A1 AU2016303614A1 AU2016303614A AU2016303614A AU2016303614A1 AU 2016303614 A1 AU2016303614 A1 AU 2016303614A1 AU 2016303614 A AU2016303614 A AU 2016303614A AU 2016303614 A AU2016303614 A AU 2016303614A AU 2016303614 A1 AU2016303614 A1 AU 2016303614A1
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- 238000000034 method Methods 0.000 title claims abstract description 63
- 150000001875 compounds Chemical class 0.000 claims abstract description 152
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- 238000006243 chemical reaction Methods 0.000 claims description 14
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
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| US201562201546P | 2015-08-05 | 2015-08-05 | |
| US62/201,546 | 2015-08-05 | ||
| PCT/US2016/045553 WO2017024134A1 (en) | 2015-08-05 | 2016-08-04 | Methods of preparing 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diols and 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diamines |
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| AU2021200494A Division AU2021200494A1 (en) | 2015-08-05 | 2021-01-27 | Methods of preparing 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diols and 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diamines |
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| AU2016303614A1 true AU2016303614A1 (en) | 2018-02-15 |
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| AU2016303614A Abandoned AU2016303614A1 (en) | 2015-08-05 | 2016-08-04 | Methods of preparing 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diols and 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diamines |
| AU2021200494A Abandoned AU2021200494A1 (en) | 2015-08-05 | 2021-01-27 | Methods of preparing 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diols and 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diamines |
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| US (1) | US9751863B2 (OSRAM) |
| EP (1) | EP3331866B1 (OSRAM) |
| JP (2) | JP6816106B2 (OSRAM) |
| CN (1) | CN108349933A (OSRAM) |
| AU (2) | AU2016303614A1 (OSRAM) |
| CA (1) | CA2993615A1 (OSRAM) |
| MX (1) | MX365590B (OSRAM) |
| WO (1) | WO2017024134A1 (OSRAM) |
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| JP2017529382A (ja) | 2014-09-29 | 2017-10-05 | アギオス ファーマシューティカルス，インコーポレーテッド | 治療活性を有する化合物及びその使用方法 |
| KR102628370B1 (ko) | 2015-02-04 | 2024-01-24 | 르 라보레또레 쎄르비에르 | 치료적 활성 화합물 및 이들의 사용 방법 |
| US9751863B2 (en) * | 2015-08-05 | 2017-09-05 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| IL311873A (en) | 2015-10-15 | 2024-06-01 | Agios Pharmaceuticals Inc | Combination therapy for treating malignancies |
| CA3002029A1 (en) | 2015-10-15 | 2017-04-20 | Celgene Corporation | Combination therapy for treating malignancies |
| IL299563A (en) | 2015-12-04 | 2023-02-01 | Agios Pharmaceuticals Inc | Methods of treatment of acute myeloid leukemia characterized by the presence of a mutant allele of idh2 and the absence of a mutant allele of nras |
| CA3015753A1 (en) | 2016-02-26 | 2017-08-31 | Celgene Corporation | Idh2 inhibitors for the treatment of haematological maligancies and solid tumours |
| BR112019004356A2 (pt) | 2016-09-07 | 2019-05-28 | Celgene Corporation | composições de comprimido |
| EP3618828B1 (en) | 2017-05-05 | 2023-11-01 | Memorial Sloan Kettering Cancer Center | Methods of treatment of myeloproliferative neoplasm |
| US20220017489A1 (en) | 2018-11-02 | 2022-01-20 | Celgene Corporation | Solid dispersions for treatment of cancer |
| US20220017490A1 (en) | 2018-11-02 | 2022-01-20 | Celgene Corporation | Co-crystals of 2-methyl-1 -[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl) pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol, compositions and methods of use thereof |
| US12215094B2 (en) | 2018-11-02 | 2025-02-04 | Celgene Corporation | Solid forms of 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl) amino]propan-2-ol |
| EP4058028B1 (en) | 2019-11-14 | 2025-03-05 | Celgene Corporation | Pediatric formulations for treatment of cancer |
| CN111592524B (zh) * | 2020-05-20 | 2023-11-17 | 温州市天聚万迅信息科技有限公司 | 恩西德尼的制备方法 |
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| US2390529A (en) | 1942-02-03 | 1945-12-11 | Ernst A H Friedheim | Hydrazino-1,3,5-triazino derivatives of substituted phenylarsenic compounds |
| JPS5170779A (ja) * | 1974-12-17 | 1976-06-18 | Nippon Shinyaku Co Ltd | Shinkinaguanamidoruino seiho |
| JPS58186682A (ja) | 1982-04-27 | 1983-10-31 | 日本化薬株式会社 | セルロ−ス又はセルロ−ス含有繊維材料の染色法 |
| DE3512630A1 (de) | 1985-04-06 | 1986-10-23 | Hoechst Ag, 6230 Frankfurt | Verfahren zum faerben oder bedrucken von cellulosefasern oder cellulosemischfasern |
| DE59106971D1 (de) | 1990-07-12 | 1996-01-11 | Ciba Geigy Ag | Verfahren zur photochemischen und thermischen Stabilisierung von Polyamid-Fasermaterialien. |
| JPH11158073A (ja) | 1997-09-26 | 1999-06-15 | Takeda Chem Ind Ltd | アデノシンａ３拮抗剤 |
| EP1187825A1 (en) | 1999-06-07 | 2002-03-20 | Shire Biochem Inc. | Thiophene integrin inhibitors |
| DK2256108T3 (en) | 2002-07-18 | 2016-04-11 | Janssen Pharmaceutica Nv | Substituted triazinkinaseinhibitorer |
| BRPI0810921A2 (pt) | 2007-04-30 | 2014-10-29 | Prometic Biosciences Inc | Derivados de triazina, composições contendo tais derivados e métodos de tratamento de câncer e doenças autoimunes usando tais compostos |
| GB0805477D0 (en) | 2008-03-26 | 2008-04-30 | Univ Nottingham | Pyrimidines triazines and their use as pharmaceutical agents |
| CA2764785C (en) | 2009-06-08 | 2015-10-27 | California Capital Equity, Llc | Triazine derivatives and their therapeutical applications |
| ES2675760T3 (es) * | 2012-01-06 | 2018-07-12 | Agios Pharmaceuticals, Inc. | Compuestos terapéuticamente activos y métodos de uso de los mismos |
| WO2013133367A1 (ja) | 2012-03-09 | 2013-09-12 | カルナバイオサイエンス株式会社 | 新規トリアジン誘導体 |
| KR102302091B1 (ko) | 2013-07-11 | 2021-09-16 | 아지오스 파마슈티컬스 아이엔씨. | 암 치료용의 ｉｄｈ２ 돌연변이체 억제제로서의 ｎ,６-비스(아릴 또는 헤테로아릴)-１，３，５-트리아진-２,４-디아민 화합물 |
| WO2015003360A2 (en) * | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| US9579324B2 (en) * | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| ES2886211T3 (es) | 2013-08-02 | 2021-12-16 | Agios Pharmaceuticals Inc | Compuestos terapéuticamente activos y sus métodos de uso |
| JP2017529382A (ja) | 2014-09-29 | 2017-10-05 | アギオス ファーマシューティカルス，インコーポレーテッド | 治療活性を有する化合物及びその使用方法 |
| KR102628370B1 (ko) | 2015-02-04 | 2024-01-24 | 르 라보레또레 쎄르비에르 | 치료적 활성 화합물 및 이들의 사용 방법 |
| US9751863B2 (en) * | 2015-08-05 | 2017-09-05 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
-
2016
- 2016-08-04 US US15/229,011 patent/US9751863B2/en active Active
- 2016-08-04 AU AU2016303614A patent/AU2016303614A1/en not_active Abandoned
- 2016-08-04 JP JP2018505739A patent/JP6816106B2/ja active Active
- 2016-08-04 CN CN201680045391.6A patent/CN108349933A/zh active Pending
- 2016-08-04 WO PCT/US2016/045553 patent/WO2017024134A1/en not_active Ceased
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2020
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2021
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| CA2993615A1 (en) | 2017-02-09 |
| EP3331866B1 (en) | 2023-07-26 |
| CN108349933A (zh) | 2018-07-31 |
| JP2018528182A (ja) | 2018-09-27 |
| AU2021200494A1 (en) | 2021-03-11 |
| MX365590B (es) | 2019-06-07 |
| US20170037031A1 (en) | 2017-02-09 |
| JP6816106B2 (ja) | 2021-01-20 |
| EP3331866A1 (en) | 2018-06-13 |
| WO2017024134A1 (en) | 2017-02-09 |
| MX2018001424A (es) | 2018-08-01 |
| US9751863B2 (en) | 2017-09-05 |
| JP2021063097A (ja) | 2021-04-22 |
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