AU2016270474A1 - Lym-1 and Lym-2 targeted CAR cell immunotherapy - Google Patents
Lym-1 and Lym-2 targeted CAR cell immunotherapy Download PDFInfo
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- AU2016270474A1 AU2016270474A1 AU2016270474A AU2016270474A AU2016270474A1 AU 2016270474 A1 AU2016270474 A1 AU 2016270474A1 AU 2016270474 A AU2016270474 A AU 2016270474A AU 2016270474 A AU2016270474 A AU 2016270474A AU 2016270474 A1 AU2016270474 A1 AU 2016270474A1
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- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C07K—PEPTIDES
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C07—ORGANIC CHEMISTRY
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- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
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- G01N2800/00—Detection or diagnosis of diseases
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- G—PHYSICS
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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| US201562171004P | 2015-06-04 | 2015-06-04 | |
| US62/171,004 | 2015-06-04 | ||
| PCT/US2016/035916 WO2016197064A1 (en) | 2015-06-04 | 2016-06-03 | Lym-1 and lym-2 targeted car cell immunotherapy |
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| AU2016270474A1 true AU2016270474A1 (en) | 2018-01-04 |
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| EP2934581B1 (en) | 2012-12-18 | 2022-09-14 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
| US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| KR101605421B1 (ko) | 2014-03-05 | 2016-03-23 | 국립암센터 | B 세포 림프종 세포를 특이적으로 인지하는 단일클론항체 및 이의 용도 |
| AU2016209032A1 (en) | 2015-01-23 | 2017-08-10 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| EP3468994A1 (en) * | 2016-06-08 | 2019-04-17 | Intrexon Corporation | Cd33 specific chimeric antigen receptors |
| EP3471767A4 (en) | 2016-06-15 | 2020-01-15 | Icahn School of Medicine at Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
| US20200165342A1 (en) * | 2017-02-21 | 2020-05-28 | Eutilex Co., Ltd. | Hla-dr car-t compositions and methods of making and using the same |
| EP3606555A4 (en) * | 2017-04-07 | 2021-08-04 | Icahn School of Medicine at Mount Sinai | INFLUENZA VIRUS TYPE B ANTI-NEURAMINIDASE ANTIBODIES AND THEIR USES |
| WO2018204761A1 (en) * | 2017-05-05 | 2018-11-08 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Rapid method for the culture of tumor infiltrating lymphocytes |
| JP2020523586A (ja) * | 2017-06-13 | 2020-08-06 | ベックマン コールター， インコーポレイテッド | Ｆｌｕｏ感受性フローサイトメトリーによる白血球由来マイクロベシクルの検出 |
| EP3810634A4 (en) | 2018-06-21 | 2022-07-27 | Icahn School of Medicine at Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| CA3109209A1 (en) | 2018-08-10 | 2020-02-13 | Eutilex Co., Ltd. | Chimeric antigen receptor that binds hla-dr and car-t cell |
| TWI850282B (zh) * | 2018-11-27 | 2024-08-01 | 香港商弘年發展有限公司 | 用於治療癌症之質體建構體和使用方法 |
| MX2021009744A (es) * | 2019-02-15 | 2021-11-12 | Univ Southern California | Composiciones de anticuerpos lym-1 y lym-2 y constructos car mejorados. |
| WO2020261231A1 (en) * | 2019-06-27 | 2020-12-30 | Eutilex Co., Ltd. | Chimeric antigen receptor with 4-1bb costimulatory domain |
| CN116490518A (zh) | 2020-07-17 | 2023-07-25 | 西穆尔克斯股份有限公司 | 用于重定向免疫抑制信号传导的嵌合MyD88受体及相关组合物和方法 |
| IL313935A (en) * | 2021-12-30 | 2024-08-01 | Tr1X Inc | CD4+ T cells expressing IL-10 chimeric antigen receptors and uses thereof |
| CN117186242A (zh) * | 2023-07-14 | 2023-12-08 | 上海市浦东医院（复旦大学附属浦东医院） | 一种靶向vegfr2和pd-1的双靶点嵌合抗原受体及其应用 |
| CN117106098A (zh) * | 2023-07-14 | 2023-11-24 | 上海市浦东医院（复旦大学附属浦东医院） | Vegfr2和pd-1双靶点三代嵌合抗原受体及其应用 |
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| US20200165342A1 (en) * | 2017-02-21 | 2020-05-28 | Eutilex Co., Ltd. | Hla-dr car-t compositions and methods of making and using the same |
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2016
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- 2016-06-03 WO PCT/US2016/035916 patent/WO2016197064A1/en not_active Ceased
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2017
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2020
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2021
- 2021-11-09 JP JP2021182547A patent/JP2022051570A/ja active Pending
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| EP3302559B1 (en) | 2022-01-12 |
| IL256058B (en) | 2021-09-30 |
| EP3302559A1 (en) | 2018-04-11 |
| IL256058A (en) | 2018-01-31 |
| US20160355590A1 (en) | 2016-12-08 |
| JP2022051570A (ja) | 2022-03-31 |
| JP2018524973A (ja) | 2018-09-06 |
| JP7010473B2 (ja) | 2022-02-10 |
| WO2016197064A1 (en) | 2016-12-08 |
| CA2987992A1 (en) | 2016-12-08 |
| HK1253549A1 (zh) | 2019-06-21 |
| US20210147551A1 (en) | 2021-05-20 |
| CN107847601A (zh) | 2018-03-27 |
| EP3302559A4 (en) | 2019-02-20 |
| US10711064B2 (en) | 2020-07-14 |
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