AU2016240220B2 - Designed ankyrin repeat domains with binding specificity for serum albumin - Google Patents

Designed ankyrin repeat domains with binding specificity for serum albumin Download PDF

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Publication number
AU2016240220B2
AU2016240220B2 AU2016240220A AU2016240220A AU2016240220B2 AU 2016240220 B2 AU2016240220 B2 AU 2016240220B2 AU 2016240220 A AU2016240220 A AU 2016240220A AU 2016240220 A AU2016240220 A AU 2016240220A AU 2016240220 B2 AU2016240220 B2 AU 2016240220B2
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Australia
Prior art keywords
ankyrin repeat
designed ankyrin
binding specificity
serum albumin
repeat domains
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Ceased
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AU2016240220A
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AU2016240220A1 (en
Inventor
Johan ABRAM SALIBA
Talitha BAKKER
Hans Kaspar Binz
Ignacio DOLADO
Patrik Forrer
Maya Gulotti-Georgieva
Frieder W. Merz
Douglas Phillips
Ivo Sonderegger
Daniel Steiner
Michael T. Stumpp
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Molecular Partners AG
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Molecular Partners AG
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Publication of AU2016240220B2 publication Critical patent/AU2016240220B2/en
Priority to AU2020201264A priority Critical patent/AU2020201264A1/en
Priority to AU2021286418A priority patent/AU2021286418B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
AU2016240220A 2015-04-02 2016-04-01 Designed ankyrin repeat domains with binding specificity for serum albumin Ceased AU2016240220B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2020201264A AU2020201264A1 (en) 2015-04-02 2020-02-21 Designed ankyrin repeat domains with binding specificity for serum albumin
AU2021286418A AU2021286418B2 (en) 2015-04-02 2021-12-17 Designed ankyrin repeat domains with binding specificity for serum albumin

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP15162511.8 2015-04-02
EP15162502.7 2015-04-02
EP15162502 2015-04-02
EP15162511 2015-04-02
PCT/EP2016/057272 WO2016156596A1 (en) 2015-04-02 2016-04-01 Designed ankyrin repeat domains with binding specificity for serum albumin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020201264A Division AU2020201264A1 (en) 2015-04-02 2020-02-21 Designed ankyrin repeat domains with binding specificity for serum albumin

Publications (2)

Publication Number Publication Date
AU2016240220A1 AU2016240220A1 (en) 2017-10-19
AU2016240220B2 true AU2016240220B2 (en) 2019-11-21

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AU2016240220A Ceased AU2016240220B2 (en) 2015-04-02 2016-04-01 Designed ankyrin repeat domains with binding specificity for serum albumin
AU2020201264A Abandoned AU2020201264A1 (en) 2015-04-02 2020-02-21 Designed ankyrin repeat domains with binding specificity for serum albumin
AU2021286418A Active AU2021286418B2 (en) 2015-04-02 2021-12-17 Designed ankyrin repeat domains with binding specificity for serum albumin

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AU2020201264A Abandoned AU2020201264A1 (en) 2015-04-02 2020-02-21 Designed ankyrin repeat domains with binding specificity for serum albumin
AU2021286418A Active AU2021286418B2 (en) 2015-04-02 2021-12-17 Designed ankyrin repeat domains with binding specificity for serum albumin

Country Status (20)

Country Link
US (3) US9458211B1 (enExample)
EP (2) EP4272838A3 (enExample)
JP (1) JP6552636B2 (enExample)
KR (2) KR102427117B1 (enExample)
CN (1) CN107454904A (enExample)
AU (3) AU2016240220B2 (enExample)
BR (1) BR112017020986A2 (enExample)
CA (1) CA2979602C (enExample)
CL (1) CL2017002454A1 (enExample)
CO (1) CO2017009954A2 (enExample)
ES (1) ES2953482T3 (enExample)
IL (2) IL276944B (enExample)
MX (2) MX2022008302A (enExample)
MY (1) MY179505A (enExample)
NZ (1) NZ735803A (enExample)
PH (1) PH12017501792B1 (enExample)
RU (1) RU2769470C2 (enExample)
SA (1) SA517390092B1 (enExample)
SG (1) SG11201707606RA (enExample)
WO (1) WO2016156596A1 (enExample)

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JP2024508969A (ja) 2021-03-09 2024-02-28 モレキュラー パートナーズ アクチェンゲゼルシャフト 新規のＤＡＲＰｉｎに基づくＣＤ３３エンゲージャ
WO2022190008A1 (en) 2021-03-09 2022-09-15 Molecular Partners Ag Protease cleavable prodrugs
CN118354784A (zh) 2021-12-14 2024-07-16 分子合作伙伴股份公司 具有双重结合特异性的经设计的重复结构域及其用途
CN114957426B (zh) * 2022-06-02 2023-05-16 华南师范大学 Sp6rars及其在防治蜚蠊目昆虫中的应用
AU2023317655A1 (en) 2022-08-01 2025-01-23 Molecular Partners Ag Charge modified designed repeat domains and their use
WO2024038307A1 (en) 2022-08-19 2024-02-22 Novartis Ag Dosing regimens for sars-cov-2 binding molecules
TW202448926A (zh) 2023-02-17 2024-12-16 比利時商艾伯霖克斯公司 結合新生兒fc受體之多肽
WO2024179981A1 (en) 2023-02-27 2024-09-06 Molecular Partners Ag Darpins for use in reducing renal accumulation of drugs
WO2024251628A1 (en) 2023-06-06 2024-12-12 Molecular Partners Ag Recombinant cd16a binding proteins and their use
WO2024251742A1 (en) 2023-06-06 2024-12-12 Molecular Partners Ag Recombinant cd2 binding proteins and their use
WO2024251695A1 (en) 2023-06-06 2024-12-12 Molecular Partners Ag Recombinant cd47 binding proteins and their use
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WO2025146490A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Recombinant cd117 binding proteins and their use
WO2025146491A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent
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US10155791B2 (en) 2018-12-18
WO2016156596A1 (en) 2016-10-06
PH12017501792B1 (en) 2022-07-20
AU2021286418B2 (en) 2024-01-04
EP3277711C0 (en) 2023-06-07
NZ735803A (en) 2021-12-24
MX2022008302A (es) 2023-02-28
US20160362453A1 (en) 2016-12-15
MY179505A (en) 2020-11-09
SG11201707606RA (en) 2017-10-30
BR112017020986A2 (pt) 2018-08-14
AU2016240220A1 (en) 2017-10-19
CN107454904A (zh) 2017-12-08
JP6552636B2 (ja) 2019-07-31
AU2021286418A1 (en) 2022-01-20
RU2769470C2 (ru) 2022-04-01
ES2953482T3 (es) 2023-11-13
IL276944A (en) 2020-10-29
MX393655B (es) 2025-03-24
US20190263869A1 (en) 2019-08-29
KR102427117B1 (ko) 2022-07-29
US20160289285A1 (en) 2016-10-06
JP2018511327A (ja) 2018-04-26
MX2017012485A (es) 2018-04-11
RU2017134456A3 (enExample) 2019-10-08
KR20220109488A (ko) 2022-08-04
US9458211B1 (en) 2016-10-04
CA2979602C (en) 2022-12-20
CL2017002454A1 (es) 2018-05-25
US11332501B2 (en) 2022-05-17
EP4272838A3 (en) 2024-01-10
CA2979602A1 (en) 2016-10-06
CO2017009954A2 (es) 2018-02-20
SA517390092B1 (ar) 2022-03-03
AU2020201264A1 (en) 2020-03-12
EP4272838A2 (en) 2023-11-08
EP3277711B1 (en) 2023-06-07
EP3277711A1 (en) 2018-02-07
RU2017134456A (ru) 2019-04-03
KR20170131515A (ko) 2017-11-29
IL276944B (en) 2022-07-01
PH12017501792A1 (en) 2019-01-21
IL254788B (en) 2020-09-30
EP3277711B9 (en) 2023-08-16
HK1244009A1 (en) 2018-07-27
IL254788A0 (en) 2017-12-31

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