AU2016239331C1 - A novel IL33 form, mutated forms of IL33, antibodies, assays and methods of using the same - Google Patents

A novel IL33 form, mutated forms of IL33, antibodies, assays and methods of using the same Download PDF

Info

Publication number
AU2016239331C1
AU2016239331C1 AU2016239331A AU2016239331A AU2016239331C1 AU 2016239331 C1 AU2016239331 C1 AU 2016239331C1 AU 2016239331 A AU2016239331 A AU 2016239331A AU 2016239331 A AU2016239331 A AU 2016239331A AU 2016239331 C1 AU2016239331 C1 AU 2016239331C1
Authority
AU
Australia
Prior art keywords
assays
antibodies
novel
methods
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2016239331A
Other languages
English (en)
Other versions
AU2016239331A1 (en
AU2016239331B2 (en
Inventor
Robin BUTLER
Sara Carmen
Emma S. Cohen
Elizabeth H. England
Kirsty HOUSLAY
Benjamin P. Kemp
David C. Lowe
Tomas M. Mustelin
Catherine L. Overed-Sayer
David G. Rees
Ian C. Scott
Matthew Sleeman
Martin D. Strain
Katherine A. Vousden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MedImmune Ltd
Original Assignee
MedImmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MedImmune Ltd filed Critical MedImmune Ltd
Publication of AU2016239331A1 publication Critical patent/AU2016239331A1/en
Application granted granted Critical
Publication of AU2016239331B2 publication Critical patent/AU2016239331B2/en
Priority to AU2019250213A priority Critical patent/AU2019250213B2/en
Publication of AU2016239331C1 publication Critical patent/AU2016239331C1/en
Priority to AU2021257881A priority patent/AU2021257881B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Environmental Sciences (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
AU2016239331A 2015-03-31 2016-03-30 A novel IL33 form, mutated forms of IL33, antibodies, assays and methods of using the same Active AU2016239331C1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2019250213A AU2019250213B2 (en) 2015-03-31 2019-10-17 A novel il33 form, mutated forms of il33, antibodies, assays and methods of using the same
AU2021257881A AU2021257881B2 (en) 2015-03-31 2021-10-25 A novel il33 form, mutated forms of il33, antibodies, assays and methods of using the same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562140913P 2015-03-31 2015-03-31
US62/140,913 2015-03-31
PCT/EP2016/056973 WO2016156440A1 (en) 2015-03-31 2016-03-30 A novel il33 form, mutated forms of il33, antibodies, assays and methods of using the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2019250213A Division AU2019250213B2 (en) 2015-03-31 2019-10-17 A novel il33 form, mutated forms of il33, antibodies, assays and methods of using the same

Publications (3)

Publication Number Publication Date
AU2016239331A1 AU2016239331A1 (en) 2017-10-26
AU2016239331B2 AU2016239331B2 (en) 2019-07-25
AU2016239331C1 true AU2016239331C1 (en) 2020-01-30

Family

ID=55640748

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2016239331A Active AU2016239331C1 (en) 2015-03-31 2016-03-30 A novel IL33 form, mutated forms of IL33, antibodies, assays and methods of using the same
AU2019250213A Active AU2019250213B2 (en) 2015-03-31 2019-10-17 A novel il33 form, mutated forms of il33, antibodies, assays and methods of using the same
AU2021257881A Active AU2021257881B2 (en) 2015-03-31 2021-10-25 A novel il33 form, mutated forms of il33, antibodies, assays and methods of using the same

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2019250213A Active AU2019250213B2 (en) 2015-03-31 2019-10-17 A novel il33 form, mutated forms of il33, antibodies, assays and methods of using the same
AU2021257881A Active AU2021257881B2 (en) 2015-03-31 2021-10-25 A novel il33 form, mutated forms of il33, antibodies, assays and methods of using the same

Country Status (29)

Country Link
US (3) US10668150B2 (OSRAM)
EP (3) EP4374916A3 (OSRAM)
JP (3) JP6862351B2 (OSRAM)
KR (1) KR102261618B1 (OSRAM)
CN (1) CN108064236B (OSRAM)
AU (3) AU2016239331C1 (OSRAM)
CA (1) CA2982400C (OSRAM)
CL (2) CL2017002433A1 (OSRAM)
CO (1) CO2017010753A2 (OSRAM)
CY (1) CY1123925T1 (OSRAM)
DK (1) DK3277717T3 (OSRAM)
ES (1) ES2886114T3 (OSRAM)
HR (1) HRP20210096T1 (OSRAM)
HU (1) HUE053097T2 (OSRAM)
IL (2) IL254551A0 (OSRAM)
LT (1) LT3277717T (OSRAM)
MX (1) MX387295B (OSRAM)
MY (1) MY190209A (OSRAM)
NZ (1) NZ736026A (OSRAM)
PL (1) PL3277717T3 (OSRAM)
PT (1) PT3277717T (OSRAM)
RS (1) RS61438B1 (OSRAM)
RU (1) RU2736299C2 (OSRAM)
SG (1) SG11201707593UA (OSRAM)
SI (1) SI3277717T1 (OSRAM)
SM (1) SMT202100086T1 (OSRAM)
TW (1) TWI721973B (OSRAM)
WO (1) WO2016156440A1 (OSRAM)
ZA (1) ZA201707355B (OSRAM)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105980556B (zh) 2013-12-26 2020-10-09 田边三菱制药株式会社 人抗il－33中和单克隆抗体
EA201791029A1 (ru) 2014-11-10 2017-12-29 Дженентек, Инк. Антитела против интерлейкина-33 и их применение
CN107109494B (zh) 2014-11-10 2023-10-27 豪夫迈·罗氏有限公司 Il-33介导型疾病的治疗方法和诊断方法
ES2886114T3 (es) * 2015-03-31 2021-12-16 Medimmune Ltd Una nueva forma de IL33, formas mutadas de IL33, anticuerpos, ensayos y métodos para usar los mismos
BR112018071276A2 (pt) 2016-04-27 2019-02-12 Pfizer Inc. anticorpos anti-il-33, composições, métodos e usos dos mesmos
JOP20190093A1 (ar) 2016-10-28 2019-04-25 Lilly Co Eli أجسام مضادة لـ il-33 واستخداماتها
TWI857389B (zh) 2016-12-01 2024-10-01 美商再生元醫藥公司 治療發炎症狀的方法
DK3558369T3 (da) 2016-12-21 2025-05-19 Cephalon Llc Antistoffer, der specifikt binder til humant il-15, og anvendelse heraf
KR102751957B1 (ko) 2017-04-13 2025-01-09 리제너론 파마슈티칼스 인코포레이티드 Il33 및 il1rl1을 코딩하는 유전자에서의 위험 대립유전자를 갖는 환자에서의 폐 질환의 치료 및 저해
CN118994394A (zh) 2017-06-12 2024-11-22 蓝鳍生物医药公司 抗-il1rap抗体和抗体药物缀合物
EP3677281A4 (en) 2017-08-31 2021-05-12 Mitsubishi Tanabe Pharma Corporation THERAPEUTIC AGENT CONTAINING AN IL-33 ANTAGONIST TO TREAT ENDOMETRIOSIS
CN107973849B (zh) * 2017-11-30 2020-07-28 畜科生物工程有限公司 一种用于增强猪疫苗免疫效果的蛋白质及其应用
WO2019183375A1 (en) * 2018-03-22 2019-09-26 Eureka Therapeutics, Inc. Antibody agents specifically recognizing monocarboxylate transporter 4 and uses thereof
IL277890B2 (en) 2018-04-11 2024-03-01 Regeneron Pharma Methods for quantifying il-33
CN120267817A (zh) * 2018-09-14 2025-07-08 田边三菱制药株式会社 含有人抗il-33单克隆抗体的医药用组合物
CN111434687B (zh) * 2019-01-15 2022-03-11 南京赛新生物科技有限公司 一种抗体及其应用
CN111434680B (zh) * 2019-01-15 2021-11-23 南京赛新生物科技有限公司 一种与il33相关疾病的抗原表位肽及其应用
US20220272953A1 (en) * 2019-07-29 2022-09-01 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric il33
CN110567861B (zh) * 2019-09-09 2021-12-21 浙江普罗亭健康科技有限公司 基于质谱流式检测技术筛查具有免疫原性抗原肽的试剂盒及检测方法
US20220380450A1 (en) * 2019-11-04 2022-12-01 Medimmune Limited Methods of using il-33 antagonists
EP4055044A1 (en) * 2019-11-04 2022-09-14 MedImmune Limited Anti il-33 therapeutic agent for treating renal disorders
EP4118114A1 (en) 2020-03-13 2023-01-18 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
EP4118236A1 (en) * 2020-03-13 2023-01-18 MedImmune Limited Therapeutic methods for the treatment of subjects with risk alelles in il33
US20230174637A1 (en) * 2020-04-06 2023-06-08 Medimmune Limited Treating acute respiratory distress syndrome with il-33 axis binding antagonists
KR20230010239A (ko) * 2020-05-11 2023-01-18 메디뮨 리미티드 항-il-33 항체의 제형물
CN111378037B (zh) * 2020-06-01 2020-09-01 南京诺艾新生物技术有限公司 一种抗hIL-33人源化单抗及其应用
EP4295154A1 (en) 2021-02-18 2023-12-27 F. Hoffmann-La Roche AG Method for resolving complex, multistep antibody interactions
CN113234157B (zh) * 2021-07-09 2021-09-21 上海普铭生物科技有限公司 亲和力成熟的人源化抗人il-33单克隆抗体及其应用
PT4244252T (pt) 2021-08-27 2024-09-03 Medimmune Ltd Tratamento de doença pulmonar obstrutiva crónica com um anticorpo anti-interleucina-33
WO2023086807A1 (en) * 2021-11-10 2023-05-19 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
TW202402790A (zh) 2022-03-25 2024-01-16 英商梅迪繆思有限公司 減少呼吸系統感染之方法
TW202423973A (zh) 2022-08-19 2024-06-16 英商梅迪繆思有限公司 選擇患者以用ｉｌ—３３軸拮抗劑進行治療之方法
EP4573122A1 (en) 2022-08-19 2025-06-25 MedImmune Limited Assay for detection of il-33
TW202423978A (zh) 2022-08-19 2024-06-16 英商梅迪繆思有限公司 急性呼吸衰竭之治療
TW202423972A (zh) 2022-08-26 2024-06-16 英商梅迪繆思有限公司 使用抗介白素－３３抗體的氣喘治療
CN120936390A (zh) 2023-04-12 2025-11-11 阿斯利康(瑞典)有限公司 Steap2靶向化合物及其用途
WO2025114862A1 (en) * 2023-11-27 2025-06-05 Glaxosmithkline Intellectual Property Development Limited Il-33 binding antibodies
WO2025120567A1 (en) 2023-12-07 2025-06-12 Medimmune Limited Method of treatment of asthma
WO2025210099A1 (en) 2024-04-04 2025-10-09 Medimmune Limited Method of treatment and selecting a subject
WO2025242619A1 (en) 2024-05-20 2025-11-27 Medimmune Limited Treatment for mucus plugging
WO2025242618A1 (en) 2024-05-20 2025-11-27 Medimmune Limited Bronchiectasis treatment

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014164959A2 (en) * 2013-03-13 2014-10-09 Regeneron Pharmaceuticals, Inc. Anti-il-33 antibodies and uses thereof

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474893A (en) 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US4714681A (en) 1981-07-01 1987-12-22 The Board Of Reagents, The University Of Texas System Cancer Center Quadroma cells and trioma cells and methods for the production of same
US4741900A (en) 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
DE3668186D1 (de) 1985-04-01 1990-02-15 Celltech Ltd Transformierte myeloma-zell-linie und dieselbe verwendendes verfahren zur expression eines gens, das ein eukaryontisches polypeptid kodiert.
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4873192A (en) 1987-02-17 1989-10-10 The United States Of America As Represented By The Department Of Health And Human Services Process for site specific mutagenesis without phenotypic selection
US5892019A (en) 1987-07-15 1999-04-06 The United States Of America, As Represented By The Department Of Health And Human Services Production of a single-gene-encoded immunoglobulin
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
ATE120454T1 (de) 1988-06-14 1995-04-15 Cetus Oncology Corp Kupplungsmittel und sterisch gehinderte, mit disulfid gebundene konjugate daraus.
US4925648A (en) 1988-07-29 1990-05-15 Immunomedics, Inc. Detection and treatment of infectious and inflammatory lesions
US5601819A (en) 1988-08-11 1997-02-11 The General Hospital Corporation Bispecific antibodies for selective immune regulation and for selective immune cell binding
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5136964A (en) 1989-01-19 1992-08-11 Arnold J. Cook Warning device for windsurfing craft
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
IE63847B1 (en) 1989-05-05 1995-06-14 Res Dev Foundation A novel antibody delivery system for biological response modifiers
AU641673B2 (en) 1989-06-29 1993-09-30 Medarex, Inc. Bispecific reagents for aids therapy
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5314995A (en) 1990-01-22 1994-05-24 Oncogen Therapeutic interleukin-2-antibody based fusion proteins
JP3319594B2 (ja) 1990-03-20 2002-09-03 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク 定常領域の代わりに受容体結合性リガンドを有するキメラ抗体
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ATE175118T1 (de) 1990-10-05 1999-01-15 Medarex Inc Gezielte immunostimulierung mit bispezifischen stoffen
AU8727291A (en) 1990-10-29 1992-06-11 Cetus Oncology Corporation Bispecific antibodies, method of production, and uses thereof
ATE218889T1 (de) 1990-11-09 2002-06-15 Stephen D Gillies Cytokine immunokonjugate
JP3431140B2 (ja) 1991-04-26 2003-07-28 サーフィス・アクティブ・リミテッド 抗体およびその使用方法
ES2227512T3 (es) 1991-12-02 2005-04-01 Medical Research Council Produccion de anticuerpos contra auto-antigenos a partir de repertorios de segmentos de anticuerpos fijados en un fago.
FR2686087A1 (fr) 1992-01-13 1993-07-16 Inst Nat Sante Rech Med Nouvel antigene lymphocytaire, anticorps correspondant et leurs applications.
WO1993017715A1 (en) 1992-03-05 1993-09-16 Board Of Regents, The University Of Texas System Diagnostic and/or therapeutic agents, targeted to neovascular endothelial cells
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US6706484B1 (en) 1995-08-18 2004-03-16 Morphosys Ag Protein/(poly)peptide libraries
CA2229043C (en) 1995-08-18 2016-06-07 Morphosys Gesellschaft Fur Proteinoptimierung Mbh Protein/(poly)peptide libraries
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US6897044B1 (en) 1999-01-28 2005-05-24 Biogen Idec, Inc. Production of tetravalent antibodies
DE60044997D1 (de) 1999-07-02 2010-11-04 Morphosys Ag Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden
US6849425B1 (en) 1999-10-14 2005-02-01 Ixsys, Inc. Methods of optimizing antibody variable region binding affinity
JP5198704B2 (ja) 2000-03-03 2013-05-15 メディミューン リミティド エオタキシンに対するヒト抗体及びそれらの使用
DE60126130T2 (de) 2000-11-17 2007-10-18 The University Of Rochester In-vitro verfahren zur herstellung und identifizierung von immunglobulin moleküle in eukaryotischen zellen
DK1355919T3 (da) 2000-12-12 2011-03-14 Medimmune Llc Molekyler med længere halveringstider, sammensætninger og anvendelser deraf
AU2002327164A1 (en) 2001-01-29 2002-12-09 Idec Pharmaceuticals Corporation Engineered tetravalent antibodies and methods of use
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
EP1532175B1 (en) 2002-03-22 2012-10-17 Aprogen, Inc. Humanized antibody and process for preparing the same
NZ549040A (en) * 2004-02-17 2009-07-31 Schering Corp Use for interleukin-33 (IL33) and the IL-33 receptor complex
ES2902063T3 (es) 2006-09-08 2022-03-24 Abbvie Bahamas Ltd Proteínas de unión a interleucina-13
WO2008137552A2 (en) 2007-05-02 2008-11-13 Medimmune, Llc Anti-rage antibodies and methods of use thereof
EP2069784A4 (en) * 2007-05-18 2009-11-18 Medimmune Llc IL-33 IN INFLAMMATORY DISEASE
WO2009055074A2 (en) 2007-10-25 2009-04-30 Wyeth Erbb2 binding proteins and use thereof
US8092804B2 (en) 2007-12-21 2012-01-10 Medimmune Limited Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
MX355060B (es) * 2010-11-17 2018-04-03 Chugai Pharmaceutical Co Ltd Molecula multiespecifica de union a antigeno que tiene funcion alternativa a la funcion del factor viii de coagulacion sanguinea.
US8790651B2 (en) * 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
AR091069A1 (es) 2012-05-18 2014-12-30 Amgen Inc Proteinas de union a antigeno dirigidas contra el receptor st2
ES2886114T3 (es) * 2015-03-31 2021-12-16 Medimmune Ltd Una nueva forma de IL33, formas mutadas de IL33, anticuerpos, ensayos y métodos para usar los mismos

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014164959A2 (en) * 2013-03-13 2014-10-09 Regeneron Pharmaceuticals, Inc. Anti-il-33 antibodies and uses thereof

Also Published As

Publication number Publication date
US20240016929A1 (en) 2024-01-18
ES2886114T3 (es) 2021-12-16
RS61438B1 (sr) 2021-03-31
CY1123925T1 (el) 2022-05-27
EP3277717A1 (en) 2018-02-07
AU2021257881A1 (en) 2021-11-18
CA2982400C (en) 2023-10-24
AU2016239331A1 (en) 2017-10-26
AU2016239331B2 (en) 2019-07-25
AU2019250213A1 (en) 2019-11-07
RU2736299C2 (ru) 2020-11-13
SMT202100086T1 (it) 2021-03-15
JP2018516853A (ja) 2018-06-28
KR20170132811A (ko) 2017-12-04
DK3277717T3 (da) 2021-02-01
RU2017134909A (ru) 2019-03-28
IL280045B (en) 2021-09-30
CO2017010753A2 (es) 2018-03-20
SG11201707593UA (en) 2017-10-30
AU2021257881B2 (en) 2022-02-17
MX387295B (es) 2025-03-18
JP2021038226A (ja) 2021-03-11
EP3733701A1 (en) 2020-11-04
EP4374916A2 (en) 2024-05-29
NZ736026A (en) 2023-02-24
EP3277717B1 (en) 2020-11-18
CN108064236A (zh) 2018-05-22
HUE053097T2 (hu) 2021-06-28
PL3277717T3 (pl) 2021-05-31
MX2017012616A (es) 2018-04-10
BR112017020955A2 (pt) 2018-07-10
US20200353078A1 (en) 2020-11-12
CA2982400A1 (en) 2016-10-06
TW201704259A (zh) 2017-02-01
AU2019250213B2 (en) 2021-12-02
WO2016156440A1 (en) 2016-10-06
CN108064236B (zh) 2021-12-10
TWI721973B (zh) 2021-03-21
PT3277717T (pt) 2021-02-01
LT3277717T (lt) 2021-08-10
CL2017002433A1 (es) 2018-05-04
MY190209A (en) 2022-04-05
SI3277717T1 (sl) 2021-03-31
US20180207265A1 (en) 2018-07-26
HRP20210096T1 (hr) 2021-03-05
JP6862351B2 (ja) 2021-04-21
IL254551A0 (en) 2017-11-30
CL2020002269A1 (es) 2021-01-22
US11738081B2 (en) 2023-08-29
EP4374916A3 (en) 2024-08-28
US10668150B2 (en) 2020-06-02
HK1250728A1 (zh) 2019-01-11
ZA201707355B (en) 2022-06-29
RU2017134909A3 (OSRAM) 2019-12-23
KR102261618B1 (ko) 2021-06-04
IL280045A (en) 2021-03-01
JP2024001166A (ja) 2024-01-09

Similar Documents

Publication Publication Date Title
IL280045B (en) Novel form of il33, mutant forms of il33, antibodies, assays and methods for their use
EP3229838A4 (en) Anti-c10orf54 antibodies and uses thereof
EP3186277A4 (en) Antibodies, compositions, and uses
EP3104865A4 (en) Micro-organoids, and methods of making and using the same
EP3200823A4 (en) Multivalent meditopes, meditope-binding antibodies and uses thereof
EP3266872A4 (en) Novel anti-pad4 antibody
EP3492591A4 (en) ANTI-B7-H4 ANTIBODIES
EP3128324A4 (en) Immunochromatographic assay method
EP3145546A4 (en) Marburg monoclonal antibodies
EP3197915A4 (en) Humanized anti-hepcidin antibodies and uses thereof
EP3529273A4 (en) ANTI-O1 ANTIBODIES AND USES THEREOF
EP3194448A4 (en) Anti-vasa antibodies, and methods of production and use thereof
EP3178929A4 (en) NEW ANTI-HUMAN Igß ANTIBODY
EP3112463A4 (en) Novel anti-presepsin antibody
EP3109320A4 (en) New anti-human pai-1 antibody
EP3209686A4 (en) Monoclonal anti-gpc-1 antibodies and uses thereof
EP3262070A4 (en) Anti-amyloid-beta antibodies
EP3149039B8 (en) Anti-neurotensin antibodies and uses thereof
EP3233919A4 (en) Dicam-specific antibodies and uses thereof
EP3124500A4 (en) Anti-grpr antibody, method for producing same, detection method, use of the antibody, kit and gene construct
EP3198065A4 (en) Antibody like protein
HK40042519B (zh) 抗体、用途和方法
HK40074885B (zh) 抗c10orf54抗体及其用途
HK40003023A (en) Anti-tim-3 antibodies
HK40006212A (en) Anti-cd73 antibodies

Legal Events

Date Code Title Description
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 16 OCT 2019

TH Corrigenda

Free format text: IN VOL 33 , NO 43 , PAGE(S) 6060 UNDER THE HEADING AMENDMENTS - APPLICATION FOR AMENDMENTS UNDER THE NAME GB DESIGN LIMITED, PATENT APPLICATION NO. 2016239331 CORRECT THE DATE OF THE STATEMENTS FILED TO READ 16 OCT 2019 AND 24 OCT 2019.

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENTS FILED 16 OCT 2019 AND 24 OCT 2019

FGA Letters patent sealed or granted (standard patent)