AU2016224975B2 - Small molecules that enable cartilage rejuvanation - Google Patents

Small molecules that enable cartilage rejuvanation Download PDF

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Publication number
AU2016224975B2
AU2016224975B2 AU2016224975A AU2016224975A AU2016224975B2 AU 2016224975 B2 AU2016224975 B2 AU 2016224975B2 AU 2016224975 A AU2016224975 A AU 2016224975A AU 2016224975 A AU2016224975 A AU 2016224975A AU 2016224975 B2 AU2016224975 B2 AU 2016224975B2
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nhc
membered
alkyl
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AU2016224975A1 (en
Inventor
Denis EVSEENKO
Varghese John
Benjamin J. Van Handel
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University of California San Diego UCSD
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University of California Berkeley
University of California San Diego UCSD
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2016224975A 2015-02-27 2016-02-29 Small molecules that enable cartilage rejuvanation Active AU2016224975B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562126010P 2015-02-27 2015-02-27
US62/126,010 2015-02-27
PCT/US2016/020126 WO2016138533A2 (en) 2015-02-27 2016-02-29 Small molecules that enable cartilage rejuvanation

Publications (2)

Publication Number Publication Date
AU2016224975A1 AU2016224975A1 (en) 2017-09-07
AU2016224975B2 true AU2016224975B2 (en) 2020-10-22

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AU2016224975A Active AU2016224975B2 (en) 2015-02-27 2016-02-29 Small molecules that enable cartilage rejuvanation

Country Status (8)

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US (2) US11072592B2 (cg-RX-API-DMAC7.html)
EP (1) EP3262040A4 (cg-RX-API-DMAC7.html)
JP (1) JP2018508513A (cg-RX-API-DMAC7.html)
KR (1) KR20170122788A (cg-RX-API-DMAC7.html)
CN (1) CN107531687A (cg-RX-API-DMAC7.html)
AU (1) AU2016224975B2 (cg-RX-API-DMAC7.html)
CA (1) CA2977401A1 (cg-RX-API-DMAC7.html)
WO (1) WO2016138533A2 (cg-RX-API-DMAC7.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3262040A4 (en) 2015-02-27 2018-09-12 The Regents of The University of California Small molecules that enable cartilage rejuvanation
WO2018027193A1 (en) * 2016-08-05 2018-02-08 The Regents Of The University Of California Gp130 modulators
EP3503871B1 (en) 2016-08-26 2021-11-17 The Regents of The University of California Hair follicle stem cell activation and hair growth
CA3090545A1 (en) * 2018-02-28 2019-09-06 University Of Southern California Compositions and methods for modulating inflammatory and degenerative disorder
CN112877283A (zh) * 2021-02-10 2021-06-01 安徽农业大学 一种鸡原代软骨细胞分离培养及鉴定的方法
CN114276999A (zh) * 2022-03-03 2022-04-05 中日友好医院(中日友好临床医学研究所) 黑素瘤细胞株及其制备方法
WO2023205366A1 (en) * 2022-04-20 2023-10-26 Carthronix, Inc. Small molecule modulators of gp130 signaling pathways

Citations (7)

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WO2003015773A2 (en) * 2001-08-13 2003-02-27 Janssen Pharmaceutica N.V. 2-amino-4,5-trisubstituted thiazolyl derivatives and their use against autoimmune diseases
WO2004110350A2 (en) * 2003-05-14 2004-12-23 Torreypines Therapeutics, Inc. Compouds and uses thereof in modulating amyloid beta
WO2006122011A2 (en) * 2005-05-09 2006-11-16 Achillion Pharmaceuticals, Inc. Thiazole compounds and methods of use
WO2007031440A2 (en) * 2005-09-13 2007-03-22 Janssen Pharmaceutica N.V. 2-aniline-4-aryl substituted thiazole derivatives
WO2008147557A2 (en) * 2007-05-22 2008-12-04 Achillion Pharmaceuticals, Inc. Heteroaryl substituted thiazoles and their use as antiviral agents
CN103130792A (zh) * 2011-11-30 2013-06-05 江苏正大天晴药业股份有限公司 一种2-氨基噻唑类化合物
WO2015021191A1 (en) * 2013-08-09 2015-02-12 Neurogenetic Pharmaceuticals, Inc. Formulations containing gamma secretase modulators

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US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
DE69212850T2 (de) 1991-01-15 1997-03-06 Alcon Lab Inc Verwendung von Karrageenan in topischen ophthalmologischen Zusammensetzungen
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US7105550B2 (en) 2000-03-01 2006-09-12 Christopher Love 2,4-disubstituted thiazolyl derivatives
JP2002020286A (ja) * 2000-06-30 2002-01-23 Sumitomo Pharmaceut Co Ltd 骨・軟骨疾患治療剤
US8067608B2 (en) * 2003-09-29 2011-11-29 The Johns Hopkins University Hedgehog pathway antagonists
US8327467B2 (en) * 2005-03-16 2012-12-11 Toyama Chemical Co., Ltd. Anthranilic acid derivative or salt thereof
CA2610884A1 (en) 2005-06-09 2006-12-21 Merck & Co., Inc. Inhibitors of checkpoint kinases
JP4882076B2 (ja) * 2005-11-22 2012-02-22 国立大学法人 東京大学 インターロイキン−６（ｉｌ−６）シグナル伝達阻害剤スクリーニング方法
WO2007118149A2 (en) 2006-04-07 2007-10-18 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical Lollege Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers
US9315449B2 (en) * 2008-05-15 2016-04-19 Duke University Substituted pyrazoles as heat shock transcription factor activators
WO2013056679A1 (en) * 2011-10-21 2013-04-25 Beijing Hanmi Pharmaceutical Co., Ltd Novel heteroaryl-amino derivatives
WO2014113620A2 (en) 2013-01-18 2014-07-24 Bristol-Myers Squibb Company Phthalazinones and isoquinolinones as rock inhibitors
EP3262040A4 (en) 2015-02-27 2018-09-12 The Regents of The University of California Small molecules that enable cartilage rejuvanation

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003015773A2 (en) * 2001-08-13 2003-02-27 Janssen Pharmaceutica N.V. 2-amino-4,5-trisubstituted thiazolyl derivatives and their use against autoimmune diseases
WO2004110350A2 (en) * 2003-05-14 2004-12-23 Torreypines Therapeutics, Inc. Compouds and uses thereof in modulating amyloid beta
WO2006122011A2 (en) * 2005-05-09 2006-11-16 Achillion Pharmaceuticals, Inc. Thiazole compounds and methods of use
WO2007031440A2 (en) * 2005-09-13 2007-03-22 Janssen Pharmaceutica N.V. 2-aniline-4-aryl substituted thiazole derivatives
WO2008147557A2 (en) * 2007-05-22 2008-12-04 Achillion Pharmaceuticals, Inc. Heteroaryl substituted thiazoles and their use as antiviral agents
CN103130792A (zh) * 2011-11-30 2013-06-05 江苏正大天晴药业股份有限公司 一种2-氨基噻唑类化合物
WO2015021191A1 (en) * 2013-08-09 2015-02-12 Neurogenetic Pharmaceuticals, Inc. Formulations containing gamma secretase modulators

Also Published As

Publication number Publication date
WO2016138533A2 (en) 2016-09-01
KR20170122788A (ko) 2017-11-06
US11247974B2 (en) 2022-02-15
CA2977401A1 (en) 2016-09-01
US20190169141A1 (en) 2019-06-06
WO2016138533A3 (en) 2016-12-01
JP2018508513A (ja) 2018-03-29
US20180244638A1 (en) 2018-08-30
CN107531687A (zh) 2018-01-02
EP3262040A4 (en) 2018-09-12
EP3262040A2 (en) 2018-01-03
AU2016224975A1 (en) 2017-09-07
US11072592B2 (en) 2021-07-27

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