AU2016214140B2 - Biomarkers for pancreatic cancer - Google Patents

Biomarkers for pancreatic cancer Download PDF

Info

Publication number
AU2016214140B2
AU2016214140B2 AU2016214140A AU2016214140A AU2016214140B2 AU 2016214140 B2 AU2016214140 B2 AU 2016214140B2 AU 2016214140 A AU2016214140 A AU 2016214140A AU 2016214140 A AU2016214140 A AU 2016214140A AU 2016214140 B2 AU2016214140 B2 AU 2016214140B2
Authority
AU
Australia
Prior art keywords
protein
pdac
expression
concentration
stage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2016214140A
Other languages
English (en)
Other versions
AU2016214140A1 (en
Inventor
Tatjana Crnogorac-Jurcevic
Tomasz RADON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Queen Mary University of London
Original Assignee
Queen Mary University of London
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Queen Mary University of London filed Critical Queen Mary University of London
Publication of AU2016214140A1 publication Critical patent/AU2016214140A1/en
Application granted granted Critical
Publication of AU2016214140B2 publication Critical patent/AU2016214140B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57525Immunoassay; Biospecific binding assay; Materials therefor for cancer of the liver or pancreas
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/56Staging of a disease; Further complications associated with the disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Primary Health Care (AREA)
  • Organic Chemistry (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Gastroenterology & Hepatology (AREA)
AU2016214140A 2015-02-05 2016-02-05 Biomarkers for pancreatic cancer Active AU2016214140B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1501930.0 2015-02-05
GBGB1501930.0A GB201501930D0 (en) 2015-02-05 2015-02-05 Biomarkers for pancreatic cancer
PCT/GB2016/050277 WO2016124947A1 (en) 2015-02-05 2016-02-05 Biomarkers for pancreatic cancer

Publications (2)

Publication Number Publication Date
AU2016214140A1 AU2016214140A1 (en) 2017-08-17
AU2016214140B2 true AU2016214140B2 (en) 2021-11-04

Family

ID=52746188

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016214140A Active AU2016214140B2 (en) 2015-02-05 2016-02-05 Biomarkers for pancreatic cancer

Country Status (15)

Country Link
US (3) US10782301B2 (enExample)
EP (2) EP4458849A3 (enExample)
JP (1) JP6786499B2 (enExample)
KR (1) KR102569984B1 (enExample)
CN (1) CN107533062B (enExample)
AU (1) AU2016214140B2 (enExample)
BR (1) BR112017016808A2 (enExample)
CA (1) CA2974775C (enExample)
CL (1) CL2017001972A1 (enExample)
GB (1) GB201501930D0 (enExample)
HK (1) HK1247276A1 (enExample)
IL (1) IL253710B (enExample)
MX (1) MX2017009998A (enExample)
SG (1) SG11201706223VA (enExample)
WO (1) WO2016124947A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2442919T3 (es) 2007-03-27 2014-02-14 Immunovia Ab Firma/marcadores de proteínas para la detección de adenocarcinoma
GB201501930D0 (en) 2015-02-05 2015-03-25 Univ London Queen Mary Biomarkers for pancreatic cancer
GB201517028D0 (en) * 2015-09-25 2015-11-11 Univ London Queen Mary Novel biomarkers for pancreatic cancer
CN107674884A (zh) * 2017-09-05 2018-02-09 上海速创诊断产品有限公司 一种用于检测胰腺癌标记物reg1a的生物素化脂质体及其制备方法和应用
TWI643869B (zh) * 2017-12-14 2018-12-11 國立高雄大學 Molecular extension printing material and preparation method thereof, magnetic molecular extension printing material and preparation method thereof
US20210052231A1 (en) * 2017-12-14 2021-02-25 Salcit Technologies Private Limited Method and system for analyzing risk associated with respiratory sounds
KR102000387B1 (ko) * 2018-02-13 2019-07-15 서울대학교산학협력단 췌관내유두상점액종양의 악성도를 감별할 수 있는 단백질 바이오마커 및 그 용도
CN109358055A (zh) * 2018-12-18 2019-02-19 沈阳理工大学 增敏测定空气中氨的混合指示剂试纸及其制备和检测方法
CN111303281A (zh) * 2019-05-14 2020-06-19 长春恒晓生物科技有限责任公司 制备胰石蛋白抗体及建立检测psp方法
WO2021076036A1 (en) * 2019-10-18 2021-04-22 Reccan Diagnostics Ab Apparatuses and methods for detection of pancreatic cancer
GB202010970D0 (en) * 2020-07-16 2020-09-02 Immunovia Ab Methods, arrays and uses thereof
CN113248609B (zh) * 2021-07-14 2021-09-10 深圳市盛波尔生命科学技术有限责任公司 针对再生胰岛衍生蛋白1α的抗体组合以及包含其的检测试剂盒
CN115290732B (zh) * 2022-07-14 2025-02-25 西北大学 一种检测胰蛋白酶的电化学生物传感器及其制备方法
CN119724622B (zh) * 2024-11-25 2025-12-12 中国人民解放军总医院第五医学中心 一种评价ptt对胰腺癌治疗效果的方法、系统及设备

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008063479A2 (en) * 2006-11-17 2008-05-29 Fred Hutchinson Cancer Research Center Pancreatic cancer biomarkers
US20130216545A1 (en) * 2012-02-19 2013-08-22 Claresa Levetan Early Diagnosis and Novel Treatment of Cancer

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444879A (en) * 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
GB9827228D0 (en) 1998-12-10 1999-02-03 Univ Nottingham Cancer detection method and reagents
JP4679149B2 (ja) * 2002-09-30 2011-04-27 オンコセラピー・サイエンス株式会社 ヒト膵癌に関連する遺伝子およびポリペプチド
AU2003900747A0 (en) 2003-02-18 2003-03-06 Garvan Institute Of Medical Research Diagnosis and treatment of pancreatic cancer
WO2004099432A2 (en) 2003-05-02 2004-11-18 The Johns Hopkins University Identification of biomarkers for detecting pancreatic cancer
AU2004239416A1 (en) 2003-05-15 2004-11-25 Europroteome Ag Methods and applications of biomarker profiles in the diagnosis and treatment of breast cancer
DE102004042822A1 (de) 2004-08-31 2006-03-16 Technische Universität Dresden Verbindungen und Methoden zur Behandlung, Diagnose und Prognose bei Pankreaserkrankungen
AU2006207954A1 (en) 2005-01-28 2006-08-03 Childrens Medical Center Corporation Methods for diagnosis and prognosis of epithelial cancers
AU2006261671A1 (en) 2005-06-27 2007-01-04 John Wayne Cancer Institute Molecular/genetic aberrations in surgical margins of resected pancreatic cancer represents neoplastic disease that correlates with disease outcome
WO2007035684A2 (en) 2005-09-16 2007-03-29 Primera Biosystems, Inc. Method for quantitative detection of short rna molecules
JP5490413B2 (ja) 2006-01-05 2014-05-14 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 膵内分泌腫瘍及び膵腺房腫瘍におけるマイクロrna発現異常
CN101421622A (zh) 2006-02-17 2009-04-29 儿童医学中心公司 作为癌症生物标志物的游离ngal
US20070231822A1 (en) 2006-02-28 2007-10-04 Michael Mitas Methods for the detection and treatment of cancer
WO2008036765A2 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Micrornas differentially expressed in pancreatic diseases and uses thereof
US20080199455A1 (en) 2006-10-03 2008-08-21 Lobie Peter E Conformation specific antibodies that bind trefoil factors and methods of treating cancers and proliferation disorders using same
WO2008136971A1 (en) 2007-04-30 2008-11-13 The Ohio State University Research Foundation Methods for differentiating pancreatic cancer from normal pancreatic function and/or chronic pancreatitis
CA2723972A1 (en) 2008-05-12 2009-11-19 Genomic Health Inc. Tests to predict responsiveness of cancer patients to chemotherapy treatment options
US20090304700A1 (en) 2008-06-06 2009-12-10 Neuren Pharmaceuticals, Ltd. Conformation specific antibodies that bind trefoil factors
JP2012100536A (ja) * 2009-03-02 2012-05-31 Genescience Co Ltd 血液試料に含まれる単核球細胞を用いた癌関連遺伝子の発現解析による癌の遺伝子検査方法
EP2525820B1 (en) * 2010-01-19 2016-05-11 Immunomedics, Inc. Novel class of monospecific and bispecific humanized antibodies that target the insulin-like growth factor type i receptor (igf-1r)
EP2415877A3 (en) * 2010-02-17 2012-02-15 Deutsches Krebsforschungszentrum Means and methods for diagnosing pancreatic cancer
WO2011137288A2 (en) 2010-04-30 2011-11-03 The Ohio State University Mirna networks in cancers and leukemias and uses thereof
WO2012100339A1 (en) * 2011-01-27 2012-08-02 University Health Network Methods and compositions for the detection of pancreatic cancer
US9644241B2 (en) 2011-09-13 2017-05-09 Interpace Diagnostics, Llc Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease
US20140235494A1 (en) 2011-09-21 2014-08-21 The Universify of North Carolina at Chapel Hill Methods, Kits and Computer Program Products using Hepatocellular Carcinoma (HCC) Biomarkers
DE102012204366B4 (de) 2011-12-16 2017-07-27 Siemens Aktiengesellschaft Verfahren und Kit zur Identifizierung und Quantifizierung von einer einzelsträngigen Ziel-Nukleinsäure
US20150018235A1 (en) 2012-01-13 2015-01-15 Oncocyte Corporation Methods and Compositions for the Treatment and Diagnosis of Pancreatic Cancer
EP2804958A2 (en) 2012-01-16 2014-11-26 Herlev Hospital Microrna for diagnosis of pancreatic cancer and/or prognosis of patients with pancreatic cancer by blood samples
WO2013152989A2 (en) 2012-04-10 2013-10-17 Eth Zurich Biomarker assay and uses thereof for diagnosis, therapy selection, and prognosis of cancer
US20130317083A1 (en) 2012-05-04 2013-11-28 Thomas Jefferson University Non-coding transcripts for determination of cellular states
WO2014062856A1 (en) * 2012-10-16 2014-04-24 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
US20140271621A1 (en) 2013-03-14 2014-09-18 Abbott Laboratories Methods of prognosis and diagnosis of pancreatic cancer
US20150018230A1 (en) 2013-06-11 2015-01-15 Indiana University Research And Technology Corp. PLASMA miRNA SIGNATURE FOR THE ACCURATE DIAGNOSIS OF PANCREATIC DUCTAL ADENOCARCINOMA
GB201501930D0 (en) 2015-02-05 2015-03-25 Univ London Queen Mary Biomarkers for pancreatic cancer
GB201517028D0 (en) 2015-09-25 2015-11-11 Univ London Queen Mary Novel biomarkers for pancreatic cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008063479A2 (en) * 2006-11-17 2008-05-29 Fred Hutchinson Cancer Research Center Pancreatic cancer biomarkers
US20130216545A1 (en) * 2012-02-19 2013-08-22 Claresa Levetan Early Diagnosis and Novel Treatment of Cancer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ARUMUGAM, T. et al. 'Trefoil Factor 1 Stimulates Both Pancreatic Cancer and Stellate Cells and Increases Metastasis.', Pancreas. 2011, vol. 40, pages 815-822 *
VON MARSCHALL, Z. et al., 'Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer', INTERNATIONAL JOURNAL OF ONCOLOGY, 2005, vol. 27, pages 669-679 *

Also Published As

Publication number Publication date
US20250251399A1 (en) 2025-08-07
EP4458849A2 (en) 2024-11-06
CN107533062A (zh) 2018-01-02
HK1247276A1 (zh) 2018-09-21
MX2017009998A (es) 2018-02-01
US11977077B2 (en) 2024-05-07
CN107533062B (zh) 2021-03-23
IL253710A0 (en) 2017-09-28
US10782301B2 (en) 2020-09-22
IL253710B (en) 2020-08-31
BR112017016808A2 (pt) 2018-04-03
AU2016214140A1 (en) 2017-08-17
KR20170129118A (ko) 2017-11-24
KR102569984B1 (ko) 2023-08-22
US20190204323A1 (en) 2019-07-04
EP3254111A1 (en) 2017-12-13
JP2018504609A (ja) 2018-02-15
WO2016124947A1 (en) 2016-08-11
CA2974775A1 (en) 2016-08-11
EP4458849A3 (en) 2024-12-04
SG11201706223VA (en) 2017-08-30
JP6786499B2 (ja) 2020-11-18
GB201501930D0 (en) 2015-03-25
US20220042998A1 (en) 2022-02-10
CA2974775C (en) 2023-11-07
CL2017001972A1 (es) 2018-03-23

Similar Documents

Publication Publication Date Title
US20250251399A1 (en) Biomarkers for pancreatic cancer
WO2021076036A1 (en) Apparatuses and methods for detection of pancreatic cancer
Fredolini et al. Immunocapture strategies in translational proteomics
CN111065925B (zh) Agrin在诊断子宫内膜癌中的应用
KR20180036787A (ko) 비소세포성 폐암 진단용 단백질 바이오마커 패널 및 이를 이용한 비소세포성 폐암 진단 방법
US9903870B2 (en) Methods and compositions for the diagnosis of ovarian cancer
US20180274037A1 (en) Novel biomarkers for pancreatic diseases
US20240044902A1 (en) Methods for the detection and treatment of ovarian cancer
WO2019115679A1 (en) A signature to assess prognosis and therapeutic regimen in liver cancer
KR101144324B1 (ko) 대장암 예후진단용 단백질 마커 디펜신?5와 rod1단백질의 조합 및 이들 각각에 대한 항체를 포함하는 대장암 예후진단키트
CN116413430B (zh) 一种用于肝癌早期预测的自身抗体/抗原组合及检测试剂盒
HK40118234A (en) Biomarkers for pancreatic cancer
CN117355748A (zh) 结直肠癌的生物标志物
CN114200138A (zh) 用于诊断和分期结直肠癌的生物标记物
US10866239B2 (en) Methods for colon hyperproliferative disorder detection, prognosis, and diagnosis
WO2010017331A1 (en) Signal pathway alterations and drug target elevations in primary metachronous metastatic colorectal cancer compared to non-metastatic disease
EP2963124B1 (en) Biomarker combinations for use in pancreatic cancer screening

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)