AU2015350128B2 - Combination therapy for treatment of resistant bacterial infections - Google Patents

Combination therapy for treatment of resistant bacterial infections Download PDF

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Publication number
AU2015350128B2
AU2015350128B2 AU2015350128A AU2015350128A AU2015350128B2 AU 2015350128 B2 AU2015350128 B2 AU 2015350128B2 AU 2015350128 A AU2015350128 A AU 2015350128A AU 2015350128 A AU2015350128 A AU 2015350128A AU 2015350128 B2 AU2015350128 B2 AU 2015350128B2
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AU
Australia
Prior art keywords
pharmaceutically acceptable
acceptable salt
sulbactam
compound
imipenem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
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AU2015350128A
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English (en)
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AU2015350128A1 (en
Inventor
Boudewijn Lodewijk Maria Dejonge
Thomas Francois Durand-Reville
John Mueller
Ruben Tommasi
Jeroen Cunera Verheijen
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Entasis Therapeutics Ltd
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Entasis Therapeutics Ltd
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Publication date
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Publication of AU2015350128A1 publication Critical patent/AU2015350128A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2015350128A 2014-11-17 2015-11-17 Combination therapy for treatment of resistant bacterial infections Active AU2015350128B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462080667P 2014-11-17 2014-11-17
US62/080,667 2014-11-17
PCT/US2015/061076 WO2016081452A1 (en) 2014-11-17 2015-11-17 Combination therapy for treatment of resistant bacterial infections

Publications (2)

Publication Number Publication Date
AU2015350128A1 AU2015350128A1 (en) 2017-06-01
AU2015350128B2 true AU2015350128B2 (en) 2019-05-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015350128A Active AU2015350128B2 (en) 2014-11-17 2015-11-17 Combination therapy for treatment of resistant bacterial infections

Country Status (31)

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US (2) US9968593B2 (enExample)
EP (1) EP3221313B1 (enExample)
JP (1) JP6764862B2 (enExample)
KR (1) KR102542392B1 (enExample)
CN (1) CN107108624B (enExample)
AU (1) AU2015350128B2 (enExample)
BR (1) BR112017010132B1 (enExample)
CA (1) CA2966632C (enExample)
CY (1) CY1121384T1 (enExample)
DK (1) DK3221313T3 (enExample)
EA (1) EA033829B1 (enExample)
ES (1) ES2717776T3 (enExample)
HK (1) HK1244798B (enExample)
HR (1) HRP20190580T1 (enExample)
HU (1) HUE044061T2 (enExample)
IL (1) IL251979B (enExample)
LT (1) LT3221313T (enExample)
ME (1) ME03357B (enExample)
MX (1) MX2017006383A (enExample)
MY (1) MY196240A (enExample)
PH (1) PH12017500852B1 (enExample)
PL (1) PL3221313T3 (enExample)
PT (1) PT3221313T (enExample)
RS (1) RS58429B1 (enExample)
SG (1) SG11201703633TA (enExample)
SI (1) SI3221313T1 (enExample)
SM (1) SMT201900187T1 (enExample)
TR (1) TR201905233T4 (enExample)
TW (1) TWI690317B (enExample)
WO (1) WO2016081452A1 (enExample)
ZA (1) ZA201703245B (enExample)

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HUE044061T2 (hu) 2014-11-17 2019-09-30 Entasis Therapeutics Ltd Kombinációs terápia rezisztens bakteriális fertõzések kezelésére
WO2017203266A1 (en) * 2016-05-25 2017-11-30 Entasis Therapeutics Limited Combination therapy for treatment of resistant bacterial infections
IL289686B2 (en) * 2016-09-16 2023-03-01 Entasis Therapeutics Ltd Beta-lactamase inhibitor compounds
EP3301094A1 (en) * 2016-09-30 2018-04-04 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
EA037916B1 (ru) * 2017-02-08 2021-06-07 Энтасис Терапеутикс Лимитед Соединения-ингибиторы бета-лактамаз
LT3630111T (lt) 2017-05-08 2022-03-10 Entasis Therapeutics, Inc. Junginiai ir būdai, skirti bakterinių infekcijų gydymui
CN109422765B (zh) * 2017-09-05 2020-08-28 香港理工大学深圳研究院 C类β-内酰胺酶抑制剂及其制备方法和应用
ES2953362T3 (es) * 2018-03-13 2023-11-10 Sepsia Therapeutics S L Péptidos de unión bacteriana para el tratamiento de enfermedades infecciosas y procesos inflamatorios relacionados
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
DK3833665T3 (da) 2018-08-09 2023-10-09 Antabio Sas Diazabicyclooctanoner som hæmmere af serin-beta-lactamaser
CN111658642A (zh) * 2019-03-05 2020-09-15 广州新创忆药物临床研究有限公司 一种治疗耐碳青霉烯类抗生素鲍曼不动杆菌感染的组合物
TWI715397B (zh) * 2019-12-31 2021-01-01 高雄榮民總醫院 根據領先標準將同儕數據繪製為圖表的方法、電腦程式產品及電腦可讀取媒體
ES3004932T3 (en) * 2020-04-02 2025-03-13 Glaxosmithkline Ip Dev Ltd Regimen for treating a neisseria gonorrhoeae infection with gepotidacin
CN117062598A (zh) * 2021-01-20 2023-11-14 恩塔西斯治疗有限公司 固定剂量抗生素组合物
WO2023206580A1 (en) * 2022-04-29 2023-11-02 Entasis Therapeutics Limited Durlobactam crystalline forms

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WO2013150296A1 (en) * 2012-04-02 2013-10-10 Astrazeneca Ab Heterobicyclic compounds as beta-lactamase inhibitors
WO2014033561A1 (en) * 2012-09-03 2014-03-06 Wockhardt Limited Antibacterial compositions
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Also Published As

Publication number Publication date
IL251979B (en) 2020-10-29
DK3221313T3 (en) 2019-04-08
CN107108624B (zh) 2020-01-07
RS58429B1 (sr) 2019-04-30
HK1244798B (en) 2020-02-21
CA2966632A1 (en) 2016-05-26
TR201905233T4 (tr) 2019-05-21
MX2017006383A (es) 2017-08-21
KR20170082635A (ko) 2017-07-14
MY196240A (en) 2023-03-24
ME03357B (me) 2019-10-20
CA2966632C (en) 2023-10-03
AU2015350128A1 (en) 2017-06-01
SI3221313T1 (sl) 2019-04-30
EP3221313A1 (en) 2017-09-27
PH12017500852A1 (en) 2017-11-06
LT3221313T (lt) 2019-03-25
PH12017500852B1 (en) 2023-03-08
US20180000800A1 (en) 2018-01-04
JP2017533945A (ja) 2017-11-16
ES2717776T3 (es) 2019-06-25
IL251979A0 (en) 2017-06-29
BR112017010132A2 (pt) 2018-01-02
US9968593B2 (en) 2018-05-15
CY1121384T1 (el) 2020-05-29
TW201625234A (zh) 2016-07-16
EA033829B1 (ru) 2019-11-29
WO2016081452A1 (en) 2016-05-26
KR102542392B1 (ko) 2023-06-09
HUE044061T2 (hu) 2019-09-30
EP3221313B1 (en) 2019-01-09
HRP20190580T1 (hr) 2019-05-17
SG11201703633TA (en) 2017-06-29
PL3221313T3 (pl) 2019-07-31
BR112017010132B1 (pt) 2023-02-14
JP6764862B2 (ja) 2020-10-07
US10376499B2 (en) 2019-08-13
NZ731601A (en) 2024-02-23
TWI690317B (zh) 2020-04-11
PT3221313T (pt) 2019-04-15
EA201791069A1 (ru) 2017-11-30
CN107108624A (zh) 2017-08-29
SMT201900187T1 (it) 2019-05-10
US20180289681A1 (en) 2018-10-11
ZA201703245B (en) 2019-08-28

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