AU2015350108B2 - Method for treating cancer - Google Patents

Method for treating cancer Download PDF

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Publication number
AU2015350108B2
AU2015350108B2 AU2015350108A AU2015350108A AU2015350108B2 AU 2015350108 B2 AU2015350108 B2 AU 2015350108B2 AU 2015350108 A AU2015350108 A AU 2015350108A AU 2015350108 A AU2015350108 A AU 2015350108A AU 2015350108 B2 AU2015350108 B2 AU 2015350108B2
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AU
Australia
Prior art keywords
amount
compound
salt
hydroxypropyl cellulose
epz
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Active
Application number
AU2015350108A
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English (en)
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AU2015350108A1 (en
Inventor
Heike KEILHACK
Tsukasa Murase
Futoshi SHIKATA
Yuta Suzuki
Brett TRUITT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Epizyme Inc
Original Assignee
Eisai R&D Management Co Ltd
Epizyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Eisai R&D Management Co Ltd, Epizyme Inc filed Critical Eisai R&D Management Co Ltd
Publication of AU2015350108A1 publication Critical patent/AU2015350108A1/en
Application granted granted Critical
Publication of AU2015350108B2 publication Critical patent/AU2015350108B2/en
Priority to AU2021204706A priority Critical patent/AU2021204706B2/en
Priority to AU2024201171A priority patent/AU2024201171A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
AU2015350108A 2014-11-17 2015-11-17 Method for treating cancer Active AU2015350108B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021204706A AU2021204706B2 (en) 2014-11-17 2021-07-06 Method for treating cancer
AU2024201171A AU2024201171A1 (en) 2014-11-17 2024-02-22 Method for treating cancer

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462080985P 2014-11-17 2014-11-17
US62/080,985 2014-11-17
US201562166572P 2015-05-26 2015-05-26
US62/166,572 2015-05-26
US201562251903P 2015-11-06 2015-11-06
US62/251,903 2015-11-06
PCT/US2015/061194 WO2016081523A1 (en) 2014-11-17 2015-11-17 Method for treating cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021204706A Division AU2021204706B2 (en) 2014-11-17 2021-07-06 Method for treating cancer

Publications (2)

Publication Number Publication Date
AU2015350108A1 AU2015350108A1 (en) 2017-05-25
AU2015350108B2 true AU2015350108B2 (en) 2021-04-08

Family

ID=56014476

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2015350108A Active AU2015350108B2 (en) 2014-11-17 2015-11-17 Method for treating cancer
AU2021204706A Active AU2021204706B2 (en) 2014-11-17 2021-07-06 Method for treating cancer
AU2024201171A Pending AU2024201171A1 (en) 2014-11-17 2024-02-22 Method for treating cancer

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2021204706A Active AU2021204706B2 (en) 2014-11-17 2021-07-06 Method for treating cancer
AU2024201171A Pending AU2024201171A1 (en) 2014-11-17 2024-02-22 Method for treating cancer

Country Status (20)

Country Link
US (3) US10786511B2 (cg-RX-API-DMAC7.html)
EP (2) EP4272742A1 (cg-RX-API-DMAC7.html)
JP (3) JP6829684B2 (cg-RX-API-DMAC7.html)
KR (3) KR102644844B1 (cg-RX-API-DMAC7.html)
CN (2) CN107249591B (cg-RX-API-DMAC7.html)
AU (3) AU2015350108B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017010166A2 (cg-RX-API-DMAC7.html)
DK (1) DK3220916T3 (cg-RX-API-DMAC7.html)
EA (1) EA201791095A1 (cg-RX-API-DMAC7.html)
ES (1) ES2947819T3 (cg-RX-API-DMAC7.html)
FI (1) FI3220916T3 (cg-RX-API-DMAC7.html)
HU (1) HUE062159T2 (cg-RX-API-DMAC7.html)
IL (4) IL296080B2 (cg-RX-API-DMAC7.html)
LT (1) LT3220916T (cg-RX-API-DMAC7.html)
MX (2) MX383484B (cg-RX-API-DMAC7.html)
PL (1) PL3220916T3 (cg-RX-API-DMAC7.html)
PT (1) PT3220916T (cg-RX-API-DMAC7.html)
SG (1) SG11201703806XA (cg-RX-API-DMAC7.html)
SI (1) SI3220916T1 (cg-RX-API-DMAC7.html)
WO (1) WO2016081523A1 (cg-RX-API-DMAC7.html)

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JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
NZ706836A (en) 2012-10-15 2019-02-22 Epizyme Inc Methods of treating cancer
WO2015085325A1 (en) 2013-12-06 2015-06-11 Epizyme, Inc. Combination therapy for treating cancer
WO2015195848A1 (en) 2014-06-17 2015-12-23 Epizyme, Inc. Ezh2 inhibitors for treating lymphoma
PT3220916T (pt) * 2014-11-17 2023-06-26 Eisai R&D Man Co Ltd Método para tratamento de cancro com n-((4,6-dimetil-2-oxo-1,2-di-hidropiridina-3-il)metil)-5-(etil(tetrahidro-2h-piran-4-il) amino)-4-metil-4'-(morfolinometil)-[1,1'-bifenilo]-3-carboxamida
MX391720B (es) 2015-04-20 2025-03-21 Epizyme Inc Terapia combinada para tratar cáncer.
MX387885B (es) 2015-06-10 2025-03-19 Epizyme Inc Inhibidores de ezh2 para tratar linfomas.
US10493076B2 (en) 2015-08-24 2019-12-03 Epizyme, Inc. Method for treating cancer
US11951108B2 (en) 2016-01-29 2024-04-09 Epizyme, Inc. Combination therapy for treating cancer
US11786533B2 (en) 2016-06-01 2023-10-17 Epizyme, Inc. Use of EZH2 inhibitors for treating cancer
JP2019521988A (ja) 2016-06-17 2019-08-08 エピザイム，インコーポレイティド 癌を処置するためのｅｚｈ２阻害剤
CN110191722B (zh) 2017-01-19 2022-03-01 第一三共株式会社 用于治疗htlv-1相关性脊髓病的药物组合物
US11642346B2 (en) 2017-03-31 2023-05-09 Epizyme, Inc. Combination therapy for treating cancer
CN110944628A (zh) 2017-06-02 2020-03-31 Epizyme股份有限公司 使用ezh2抑制剂治疗癌症
EP3678663A4 (en) 2017-09-05 2021-06-02 Epizyme, Inc. POLYTHERAPY FOR CANCER TREATMENT
KR20220130698A (ko) * 2019-12-20 2022-09-27 에피자임, 인코포레이티드 Ezh2 억제제의 결정질 하이드로브로마이드 염, 이의 제조 및 암의 치료에 유용한 약학적 조성물
JP7628876B2 (ja) 2021-04-23 2025-02-12 日立Astemo株式会社 情報処理装置、情報処理方法、プログラムおよび記憶媒体
WO2023159124A2 (en) * 2022-02-17 2023-08-24 Memorial Sloan-Kettering Cancer Center Methods for overcoming tazemetostat-resistance in cancer patients
CA3249707A1 (en) 2022-04-27 2023-11-02 Daiichi Sankyo Company, Limited COMBINATION OF AN ANTIBODY-DRUG CONJUGATE WITH AN EZH1 AND/OR EZH2 INHIBITOR

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Publication number Publication date
JP2021073241A (ja) 2021-05-13
NZ731696A (en) 2024-03-22
ES2947819T3 (es) 2023-08-21
JP6829684B2 (ja) 2021-02-10
KR20210156840A (ko) 2021-12-27
MX383484B (es) 2025-03-11
AU2021204706B2 (en) 2023-11-23
US20170360797A1 (en) 2017-12-21
CA2967664A1 (en) 2016-05-26
PT3220916T (pt) 2023-06-26
JP2017537899A (ja) 2017-12-21
CN107249591B (zh) 2024-01-30
EP3220916A1 (en) 2017-09-27
PL3220916T3 (pl) 2023-08-14
DK3220916T3 (da) 2023-06-26
FI3220916T3 (fi) 2023-06-19
JP7485810B2 (ja) 2024-05-16
WO2016081523A1 (en) 2016-05-26
CN107249591A (zh) 2017-10-13
MX2021006734A (es) 2021-07-02
IL252182A0 (en) 2017-07-31
IL304252A (en) 2023-09-01
AU2015350108A1 (en) 2017-05-25
US10786511B2 (en) 2020-09-29
IL296080A (en) 2022-11-01
KR20240035908A (ko) 2024-03-18
HUE062159T2 (hu) 2023-10-28
CN116650500A (zh) 2023-08-29
AU2021204706A1 (en) 2021-07-29
EP4272742A1 (en) 2023-11-08
IL296080B1 (en) 2023-08-01
IL252182B (en) 2022-10-01
KR102644844B1 (ko) 2024-03-07
KR20170103768A (ko) 2017-09-13
SG11201703806XA (en) 2017-06-29
IL252182B2 (en) 2023-02-01
EP3220916B1 (en) 2023-04-19
IL304252B1 (en) 2025-11-01
AU2024201171A1 (en) 2024-03-14
EP3220916A4 (en) 2018-07-11
MX2017006089A (es) 2017-12-11
US20250064822A1 (en) 2025-02-27
US12168014B2 (en) 2024-12-17
US20210060030A1 (en) 2021-03-04
IL323396A (en) 2025-11-01
KR102338802B1 (ko) 2021-12-14
IL296080B2 (en) 2023-12-01
LT3220916T (lt) 2023-07-25
NZ768247A (en) 2024-05-31
EA201791095A1 (ru) 2017-10-31
SI3220916T1 (sl) 2023-09-29
JP2023062189A (ja) 2023-05-02
BR112017010166A2 (en) 2018-02-14

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