AU2015340305B2 - Diheteroaryl histone deacetylase inhibitors and their use in therapy - Google Patents
Diheteroaryl histone deacetylase inhibitors and their use in therapy Download PDFInfo
- Publication number
- AU2015340305B2 AU2015340305B2 AU2015340305A AU2015340305A AU2015340305B2 AU 2015340305 B2 AU2015340305 B2 AU 2015340305B2 AU 2015340305 A AU2015340305 A AU 2015340305A AU 2015340305 A AU2015340305 A AU 2015340305A AU 2015340305 B2 AU2015340305 B2 AU 2015340305B2
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- Australia
- Prior art keywords
- alkyl
- amino
- pyrazin
- compound according
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- YNAVUWVOSKDBBP-UHFFFAOYSA-N C1NCCOC1 Chemical compound C1NCCOC1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 1
- DFWYCMZSXZBSPP-UHFFFAOYSA-N COC(CCCCCCNc1nccnc1)=O Chemical compound COC(CCCCCCNc1nccnc1)=O DFWYCMZSXZBSPP-UHFFFAOYSA-N 0.000 description 1
- OYWPFIUVDKHHGQ-UHFFFAOYSA-N Ic1nccnc1 Chemical compound Ic1nccnc1 OYWPFIUVDKHHGQ-UHFFFAOYSA-N 0.000 description 1
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1419228.0 | 2014-10-29 | ||
| GBGB1419228.0A GB201419228D0 (en) | 2014-10-29 | 2014-10-29 | Compounds |
| PCT/GB2015/053260 WO2016067040A1 (en) | 2014-10-29 | 2015-10-29 | Diheteroaryl histone deacetylase inhibitors and their use in therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015340305A1 AU2015340305A1 (en) | 2017-05-18 |
| AU2015340305B2 true AU2015340305B2 (en) | 2018-12-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015340305A Ceased AU2015340305B2 (en) | 2014-10-29 | 2015-10-29 | Diheteroaryl histone deacetylase inhibitors and their use in therapy |
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ707366A (en) | 2012-11-07 | 2018-11-30 | Karus Therapeutics Ltd | Novel histone deacetylase inhibitors and their use in therapy |
| NZ714283A (en) | 2013-05-10 | 2020-04-24 | Karus Therapeutics Ltd | Novel histone deacetylase inhibitors |
| GB201419228D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| GB201419264D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| EP3230259B1 (en) | 2014-12-08 | 2024-04-03 | The Research Foundation for The State University of New York | Anti-fungals targeting the synthesis of fungal shingolipids |
| US11414378B2 (en) | 2017-06-16 | 2022-08-16 | The Research Foundation For The State University Of New York | Anti-fungals compounds targeting the synthesis of fungal sphingolipids |
| JP2022538284A (ja) | 2019-06-27 | 2022-09-01 | ザ ジョージ ワシントン ユニバーシティ, ア コングレッショナリー チャータード ノット-フォー-プロフィット コーポレイション | Hdac6活性化マクロファージ、その組成物および使用 |
| US11850233B2 (en) | 2019-10-28 | 2023-12-26 | Matibur Rahaman Zamadar | Reduced adaptive microbial resistance treatment for flesh eating disease (necrotizing fasciitis) |
| CN112237994B (zh) * | 2020-09-21 | 2022-09-13 | 昆明冶金研究院有限公司 | 一种多金属硫化矿硫化锌抑制剂及其制备方法与应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0556396A1 (en) * | 1990-11-09 | 1993-08-25 | Nissan Chemical Industries, Limited | Substituted pyrazole derivative and agrohorticultural bactericide |
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| AU2015340305A1 (en) | 2017-05-18 |
| US10407435B2 (en) | 2019-09-10 |
| SG11201703492RA (en) | 2017-05-30 |
| US20170313712A1 (en) | 2017-11-02 |
| CN107001340A (zh) | 2017-08-01 |
| GB201419228D0 (en) | 2014-12-10 |
| IL251860A0 (en) | 2017-06-29 |
| EP3212625A1 (en) | 2017-09-06 |
| MX2017005422A (es) | 2017-08-24 |
| WO2016067040A1 (en) | 2016-05-06 |
| CA2966072A1 (en) | 2016-05-06 |
| KR20170081194A (ko) | 2017-07-11 |
| JP2017532357A (ja) | 2017-11-02 |
| BR112017008794A2 (pt) | 2017-12-26 |
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