SG11201703492RA - Diheteroaryl histone deacetylase inhibitors and their use in therapy - Google Patents

Diheteroaryl histone deacetylase inhibitors and their use in therapy

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Publication number
SG11201703492RA
SG11201703492RA SG11201703492RA SG11201703492RA SG11201703492RA SG 11201703492R A SG11201703492R A SG 11201703492RA SG 11201703492R A SG11201703492R A SG 11201703492RA SG 11201703492R A SG11201703492R A SG 11201703492RA SG 11201703492R A SG11201703492R A SG 11201703492RA
Authority
SG
Singapore
Prior art keywords
diheteroaryl
therapy
histone deacetylase
deacetylase inhibitors
inhibitors
Prior art date
Application number
SG11201703492RA
Inventor
Stephen Joseph Shuttleworth
Alexander Richard Liam Cecil
Somhairle Maccormick
William John Nodes
Cyrille Davy Tomassi
Franck Alexandre Silva
Original Assignee
Karus Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karus Therapeutics Ltd filed Critical Karus Therapeutics Ltd
Publication of SG11201703492RA publication Critical patent/SG11201703492RA/en

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Cardiology (AREA)
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  • Urology & Nephrology (AREA)
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  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG11201703492RA 2014-10-29 2015-10-29 Diheteroaryl histone deacetylase inhibitors and their use in therapy SG11201703492RA (en)

Applications Claiming Priority (2)

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GBGB1419228.0A GB201419228D0 (en) 2014-10-29 2014-10-29 Compounds
PCT/GB2015/053260 WO2016067040A1 (en) 2014-10-29 2015-10-29 Diheteroaryl histone deacetylase inhibitors and their use in therapy

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US (1) US10407435B2 (en)
EP (1) EP3212625A1 (en)
JP (1) JP2017532357A (en)
KR (1) KR20170081194A (en)
CN (1) CN107001340A (en)
AU (1) AU2015340305B2 (en)
BR (1) BR112017008794A2 (en)
CA (1) CA2966072A1 (en)
GB (1) GB201419228D0 (en)
IL (1) IL251860A0 (en)
MX (1) MX2017005422A (en)
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US9676765B2 (en) * 2012-11-07 2017-06-13 Karus Therapeutics Limited Histone deacetylase inhibitors and their use in therapy
LT2994465T (en) 2013-05-10 2018-10-10 Karus Therapeutics Limited Novel histone deacetylase inhibitors
GB201419264D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
GB201419228D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
WO2016094307A1 (en) 2014-12-08 2016-06-16 The Research Foundation For The State University Of New York Anti-fungals targeting the synthesis of fungal shingolipids
EP3638649A4 (en) 2017-06-16 2021-03-17 The Research Foundation for The State University of New York Anti-fungals compounds targeting the synthesis of fungal sphingolipids
US11850233B2 (en) 2019-10-28 2023-12-26 Matibur Rahaman Zamadar Reduced adaptive microbial resistance treatment for flesh eating disease (necrotizing fasciitis)
CN112237994B (en) * 2020-09-21 2022-09-13 昆明冶金研究院有限公司 Multi-metal sulfide ore zinc sulfide inhibitor and preparation method and application thereof

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