AU2015318233B2 - Heterocyclic compounds and uses thereof - Google Patents
Heterocyclic compounds and uses thereof Download PDFInfo
- Publication number
- AU2015318233B2 AU2015318233B2 AU2015318233A AU2015318233A AU2015318233B2 AU 2015318233 B2 AU2015318233 B2 AU 2015318233B2 AU 2015318233 A AU2015318233 A AU 2015318233A AU 2015318233 A AU2015318233 A AU 2015318233A AU 2015318233 B2 AU2015318233 B2 AU 2015318233B2
- Authority
- AU
- Australia
- Prior art keywords
- cancer
- compound
- substituents
- cell
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- ZFTRBKARTSPICK-UHFFFAOYSA-N BrC(c1ccccc1)c1ccccn1 Chemical compound BrC(c1ccccc1)c1ccccn1 ZFTRBKARTSPICK-UHFFFAOYSA-N 0.000 description 1
- 0 CC=*c1c[o]nc1 Chemical compound CC=*c1c[o]nc1 0.000 description 1
- JYFJKUKQUVKALR-UHFFFAOYSA-N CCc1c[s]nc1 Chemical compound CCc1c[s]nc1 JYFJKUKQUVKALR-UHFFFAOYSA-N 0.000 description 1
- DZQWXBVHOUUEJM-JTQLQIEISA-N C[C@@H](c1ncccc1)Nc1cc(-c2c(C)[o]nc2C)cnc1C(I)=N Chemical compound C[C@@H](c1ncccc1)Nc1cc(-c2c(C)[o]nc2C)cnc1C(I)=N DZQWXBVHOUUEJM-JTQLQIEISA-N 0.000 description 1
- XNIPDWBOZGXJHR-KRWDZBQOSA-N C[C@@H](c1ncccc1)Nc1cc(-c2c(C)[o]nc2C)cnc1C(c1ccc(CC(O)=C)cc1)=N Chemical compound C[C@@H](c1ncccc1)Nc1cc(-c2c(C)[o]nc2C)cnc1C(c1ccc(CC(O)=C)cc1)=N XNIPDWBOZGXJHR-KRWDZBQOSA-N 0.000 description 1
- ATHSGNPUOLNKGP-SFHVURJKSA-N C[C@@H](c1ncccc1)Nc1cc(-c2c(C)[o]nc2C)cnc1C(c1ccc(CC(OC)=C)cc1)=N Chemical compound C[C@@H](c1ncccc1)Nc1cc(-c2c(C)[o]nc2C)cnc1C(c1ccc(CC(OC)=C)cc1)=N ATHSGNPUOLNKGP-SFHVURJKSA-N 0.000 description 1
- XILPCSMEKCBYFO-UHFFFAOYSA-N C[n]1cnnc1 Chemical compound C[n]1cnnc1 XILPCSMEKCBYFO-UHFFFAOYSA-N 0.000 description 1
- OMAFFHIGWTVZOH-UHFFFAOYSA-N C[n]1nnnc1 Chemical compound C[n]1nnnc1 OMAFFHIGWTVZOH-UHFFFAOYSA-N 0.000 description 1
- GVSNQMFKEPBIOY-UHFFFAOYSA-N Cc1cnn[nH]1 Chemical compound Cc1cnn[nH]1 GVSNQMFKEPBIOY-UHFFFAOYSA-N 0.000 description 1
- UGPNLISVTOOGOK-UHFFFAOYSA-N Cc1n[o]c(C)c1-c1cnc(C(I)=N)c(N)c1 Chemical compound Cc1n[o]c(C)c1-c1cnc(C(I)=N)c(N)c1 UGPNLISVTOOGOK-UHFFFAOYSA-N 0.000 description 1
- WBILDQZWYMFRNR-UHFFFAOYSA-N Cc1n[o]nc1 Chemical compound Cc1n[o]nc1 WBILDQZWYMFRNR-UHFFFAOYSA-N 0.000 description 1
- MLLLRLNPJUWLEK-UHFFFAOYSA-N Cc1n[o]nn1 Chemical compound Cc1n[o]nn1 MLLLRLNPJUWLEK-UHFFFAOYSA-N 0.000 description 1
- GCSHUYKULREZSJ-UHFFFAOYSA-N O=C(c1ccccc1)c1ccccn1 Chemical compound O=C(c1ccccc1)c1ccccn1 GCSHUYKULREZSJ-UHFFFAOYSA-N 0.000 description 1
- UYESUYBXKHPUDU-UHFFFAOYSA-N OC(c1ccccc1)c1ccccn1 Chemical compound OC(c1ccccc1)c1ccccn1 UYESUYBXKHPUDU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462050723P | 2014-09-15 | 2014-09-15 | |
| US62/050,723 | 2014-09-15 | ||
| PCT/US2015/049522 WO2016044067A1 (en) | 2014-09-15 | 2015-09-10 | Heterocyclic compounds and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015318233A1 AU2015318233A1 (en) | 2017-04-06 |
| AU2015318233B2 true AU2015318233B2 (en) | 2020-03-12 |
Family
ID=54200077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015318233A Active AU2015318233B2 (en) | 2014-09-15 | 2015-09-10 | Heterocyclic compounds and uses thereof |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9856259B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3194392B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6832846B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015318233B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2961356C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2774177T3 (cg-RX-API-DMAC7.html) |
| TW (1) | TW201613911A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016044067A1 (cg-RX-API-DMAC7.html) |
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| SG183036A1 (en) | 2007-07-17 | 2012-08-30 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| LT2672967T (lt) | 2011-02-07 | 2018-12-10 | Plexxikon Inc. | Junginiai ir būdai skirti kinazės moduliavimui, ir jų indikacijos |
| US9358235B2 (en) | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| MX2015002887A (es) | 2012-09-06 | 2015-07-06 | Plexxikon Inc | Compuestos y metodos para la modulacion de cinasas, e indicaciones para ello. |
| PL2935248T3 (pl) | 2012-12-21 | 2018-07-31 | Plexxikon Inc | Związki i sposoby modulacji kinaz i wskazania dla nich |
| RU2680100C9 (ru) | 2013-03-15 | 2019-04-18 | Плексксикон Инк. | Гетероциклические соединения и их применения |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| RU2015149937A (ru) | 2013-05-30 | 2017-07-06 | Плексксикон Инк. | Соединения для модулирования киназы и показания к их применению |
| US9771369B2 (en) | 2014-03-04 | 2017-09-26 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| CA2966452A1 (en) * | 2014-12-17 | 2016-06-23 | Samuel David Brown | Substituted bicyclic compounds as bromodomain inhibitors |
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| ES2774178T3 (es) | 2015-05-06 | 2020-07-17 | Plexxikon Inc | Síntesis de derivados de 1h-pirrolo[2,3-B] piridina que modulan cinasas |
| TWI727949B (zh) | 2015-05-06 | 2021-05-21 | 美商普雷辛肯公司 | 調節蛋白質激酶之化合物的固態形式 |
| CN113893253A (zh) | 2015-05-22 | 2022-01-07 | 普莱希科公司 | 用于治疗braf-v600相关的疾病的plx-8394或plx-7904 |
| ES2825202T3 (es) | 2015-05-22 | 2021-05-14 | Plexxikon Inc | Síntesis de compuestos heterocíclicos |
| US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| CN113754656A (zh) | 2015-09-21 | 2021-12-07 | 普莱希科公司 | 杂环化合物及其应用 |
| RU2018123825A (ru) | 2015-12-07 | 2020-01-15 | Плексксикон Инк. | Соединения и способы для модуляции киназ, и показания для этого |
| ES2904615T3 (es) | 2016-03-16 | 2022-04-05 | Plexxikon Inc | Compuestos y métodos para la modulación de quinasas e indicaciones al respecto |
| US9822122B2 (en) | 2016-03-31 | 2017-11-21 | Oncternal Therapeutics, Inc. | Indoline analogs and uses thereof |
| TW201815766A (zh) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症 |
| EP3558991A2 (en) | 2016-12-23 | 2019-10-30 | Plexxikon Inc. | Compounds and methods for cdk8 modulation and indications therefor |
| CN108314680A (zh) * | 2017-01-16 | 2018-07-24 | 凯惠科技发展(上海)有限公司 | 一种含芳环化合物、其制备方法、药物组合物及应用 |
| ES2896502T3 (es) | 2017-03-20 | 2022-02-24 | Plexxikon Inc | Formas cristalinas de ácido 4-(1-(1,1-di(piridin-2-il) etil)-6-(3,5-dimetilisoxazol-4-il)-1H-pirrolo[3,2-b]piridin-3- il)benzoico que inhiben el bromodominio |
| US10428067B2 (en) | 2017-06-07 | 2019-10-01 | Plexxikon Inc. | Compounds and methods for kinase modulation |
| AU2018307910B2 (en) | 2017-07-25 | 2024-07-25 | Daiichi Sankyo Company, Limited | Formulations of a compound modulating kinases |
| KR102776166B1 (ko) | 2017-08-07 | 2025-03-04 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 안전한 세포 치료제를 생성하기 위한 플랫폼 |
| JP7675519B2 (ja) | 2017-10-13 | 2025-05-13 | オプナ バイオ ソシエテ アノニム | キナーゼを調節するための化合物の固体形態 |
| KR102849779B1 (ko) | 2017-10-27 | 2025-08-25 | 플렉시콘 인코퍼레이티드 | 키나제를 조정하는 화합물의 제제 |
| US11149011B2 (en) | 2018-03-20 | 2021-10-19 | Plexxikon Inc. | Compounds and methods for IDO and TDO modulation, and indications therefor |
| JP7317938B2 (ja) * | 2018-07-19 | 2023-07-31 | シェンチェン リンファン バイオテック カンパニー，リミティド | アザインドール誘導体とＦＧＦＲ及びＣ－Ｍｅｔ阻害剤としてのその使用 |
| AU2020271836B2 (en) | 2019-04-09 | 2025-11-13 | Opna Bio SA | Condensed azines for EP300 or CBP modulation and indications therefor |
| CN112174945B (zh) * | 2019-07-02 | 2022-06-07 | 四川大学 | 具有抗癌作用的吲唑类化合物及其制备方法和用途 |
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| AU2021261383A1 (en) | 2020-04-23 | 2022-11-17 | Opna Bio SA | Compounds and methods for CD73 modulation and indications therefor |
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Also Published As
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|---|---|
| EP3194392A1 (en) | 2017-07-26 |
| WO2016044067A1 (en) | 2016-03-24 |
| CA2961356A1 (en) | 2016-03-24 |
| EP3194392B1 (en) | 2020-01-01 |
| TW201613911A (en) | 2016-04-16 |
| JP2017526726A (ja) | 2017-09-14 |
| CA2961356C (en) | 2023-03-07 |
| JP6832846B2 (ja) | 2021-02-24 |
| US9856259B2 (en) | 2018-01-02 |
| AU2015318233A1 (en) | 2017-04-06 |
| ES2774177T3 (es) | 2020-07-17 |
| US20160075712A1 (en) | 2016-03-17 |
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