AU2015314783B2 - Detection of misfolded proteins - Google Patents

Detection of misfolded proteins Download PDF

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Publication number
AU2015314783B2
AU2015314783B2 AU2015314783A AU2015314783A AU2015314783B2 AU 2015314783 B2 AU2015314783 B2 AU 2015314783B2 AU 2015314783 A AU2015314783 A AU 2015314783A AU 2015314783 A AU2015314783 A AU 2015314783A AU 2015314783 B2 AU2015314783 B2 AU 2015314783B2
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AU
Australia
Prior art keywords
protein
soluble
misfolded
incubation
incubation mixture
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AU2015314783A
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AU2015314783A1 (en
Inventor
Claudio Soto JARA
Russell M. Lebovitz
Mohammad Shahnawaz
Benedikt K. VOLLRATH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Amprion Inc
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University of Texas System
University of Texas at Austin
Amprion Inc
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Assigned to BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, AMPRION, INC. reassignment BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM Request for Assignment Assignors: AMPRION, INC., BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, Jara, Claudio, Lebovitz, Russell, SHAHNAWAZ, MOHAMMAD, VOLLRATH, BENEDIKT
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
AU2015314783A 2014-09-11 2015-09-11 Detection of misfolded proteins Active AU2015314783B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462049306P 2014-09-11 2014-09-11
US62/049,306 2014-09-11
PCT/US2015/049844 WO2016040907A1 (en) 2014-09-11 2015-09-11 Detection of misfolded proteins

Publications (2)

Publication Number Publication Date
AU2015314783A1 AU2015314783A1 (en) 2017-04-27
AU2015314783B2 true AU2015314783B2 (en) 2021-10-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015314783A Active AU2015314783B2 (en) 2014-09-11 2015-09-11 Detection of misfolded proteins

Country Status (15)

Country Link
US (1) US20160077112A1 (cg-RX-API-DMAC7.html)
EP (2) EP4292654A3 (cg-RX-API-DMAC7.html)
JP (2) JP6980953B2 (cg-RX-API-DMAC7.html)
KR (1) KR102448128B1 (cg-RX-API-DMAC7.html)
CN (1) CN107208125A (cg-RX-API-DMAC7.html)
AU (1) AU2015314783B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017004899A2 (cg-RX-API-DMAC7.html)
CA (1) CA2960830C (cg-RX-API-DMAC7.html)
ES (1) ES2953855T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20231232T1 (cg-RX-API-DMAC7.html)
IL (2) IL251052B (cg-RX-API-DMAC7.html)
MX (1) MX2017003269A (cg-RX-API-DMAC7.html)
PL (1) PL3191599T3 (cg-RX-API-DMAC7.html)
SG (2) SG11201701953RA (cg-RX-API-DMAC7.html)
WO (1) WO2016040907A1 (cg-RX-API-DMAC7.html)

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US10989718B2 (en) 2014-09-11 2021-04-27 Amprion, Inc. Detection of misfolded alpha synuclein protein
GB201611840D0 (en) * 2016-07-07 2016-08-24 Univ Court Of The Univ Of Edinburgh The Alpha-synuclein detection assay
EP3583124A1 (en) 2017-02-17 2019-12-25 Bristol-Myers Squibb Company Antibodies to alpha-synuclein and uses thereof
EP3635393A4 (en) * 2017-05-16 2021-03-10 Claudio Soto-Jara ABNORMALLY FOLDING TAU PROTEIN DETECTION
CA3074914A1 (en) 2017-10-02 2019-04-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Assay for the detection of alpha-synuclein seeding activity associated with synucleinopathies
GB201720975D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Anti-alpha synuclein antibodies
GB201720970D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Antibodies
CN111630382A (zh) * 2017-12-21 2020-09-04 H.隆德贝克有限公司 α-共核蛋白病的测定、方法和治疗
CN108088816A (zh) * 2018-01-23 2018-05-29 深圳市国赛生物技术有限公司 小型特定蛋白分析仪
GB201803553D0 (en) 2018-03-06 2018-04-18 Univ Newcastle Detection of pathological protein aggregation
US20190353669A1 (en) * 2018-05-16 2019-11-21 Amprion, Inc. Detection of Brain Injury or Neurological Disease using Tau Protein
JP7125544B2 (ja) 2018-09-21 2022-08-24 ディープマインド テクノロジーズ リミテッド 品質スコアの勾配を使用した反復的なタンパク質構造予測
JP7376040B2 (ja) * 2019-09-03 2023-11-08 国立大学法人京都工芸繊維大学 神経変性疾患におけるバイオマーカー分子の検出方法
AU2020343310A1 (en) * 2019-09-04 2022-03-24 Amprion, Inc. Alpha-synuclein detection using beads
KR102277871B1 (ko) * 2019-12-17 2021-07-15 원광대학교산학협력단 소변의 알파-씨누클레인 중합체 측정에 의한 파킨슨병 진단 정보의 수집방법 및 그 키트
WO2021198098A1 (en) 2020-04-03 2021-10-07 Universität Zürich Improved method of detecting biomarkers in a biological sample
MX2022014319A (es) * 2020-05-18 2023-02-27 Amprion Inc Sustratos de alfa-sinucleína y métodos para la fabricación y el uso de los mismos.
JP2023549957A (ja) * 2020-11-21 2023-11-29 シュウェン バイオテック カンパニー リミテッド 生体試料における異常折り畳みタンパク質を検出するための装置及び方法
US20240192230A1 (en) * 2021-04-15 2024-06-13 The Brigham And Women’S Hospital, Inc. Digital Protein Misfolding Assays
CN114199875B (zh) * 2022-02-18 2022-05-20 之江实验室 一种蛋白质多聚体是否可作为力缓冲剂的判断方法及装置

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US20080118938A1 (en) * 2006-09-06 2008-05-22 Lisbell Estrada Methods and Compositions for the Detection of Protein Folding Disorders

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CA2433754A1 (en) 2001-01-03 2002-07-11 Ortho-Mcneil Pharmaceutical, Inc. Alpha synuclein aggregation assays
GB0203446D0 (en) * 2002-02-14 2002-04-03 Univ Lancaster Detection and/or monitoring of synuclein-related diseases
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WO2006088823A2 (en) * 2005-02-15 2006-08-24 Adlyfe, Inc. Method for detecting misfolded proteins and prions
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Also Published As

Publication number Publication date
PL3191599T3 (pl) 2023-12-27
EP3191599B1 (en) 2023-08-02
KR102448128B1 (ko) 2022-09-27
KR20170103741A (ko) 2017-09-13
US20160077112A1 (en) 2016-03-17
CA2960830A1 (en) 2016-03-17
IL251052A0 (en) 2017-04-30
HRP20231232T1 (hr) 2024-01-19
EP4292654A3 (en) 2024-01-03
CA2960830C (en) 2023-09-05
EP3191599C0 (en) 2023-08-02
IL251052B (en) 2022-05-01
JP2017530373A (ja) 2017-10-12
IL291809A (en) 2022-06-01
MX2017003269A (es) 2017-12-04
CN107208125A (zh) 2017-09-26
EP4292654A2 (en) 2023-12-20
AU2015314783A1 (en) 2017-04-27
WO2016040907A1 (en) 2016-03-17
SG10202008464UA (en) 2020-10-29
JP7104943B2 (ja) 2022-07-22
JP6980953B2 (ja) 2021-12-15
EP3191599A1 (en) 2017-07-19
SG11201701953RA (en) 2017-04-27
IL291809B2 (en) 2023-06-01
EP3191599A4 (en) 2018-03-14
ES2953855T3 (es) 2023-11-16
JP2022000629A (ja) 2022-01-04
BR112017004899A2 (pt) 2017-12-12

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Legal Events

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PC1 Assignment before grant (sect. 113)

Owner name: AMPRION, INC.

Free format text: FORMER APPLICANT(S): AMPRION, INC.; BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; SHAHNAWAZ, MOHAMMAD; JARA, CLAUDIO; VOLLRATH, BENEDIKT; LEBOVITZ, RUSSELL

Owner name: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Free format text: FORMER APPLICANT(S): AMPRION, INC.; BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; SHAHNAWAZ, MOHAMMAD; JARA, CLAUDIO; VOLLRATH, BENEDIKT; LEBOVITZ, RUSSELL

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