AU2015306231B2 - Genetically modified mesenchymal stem cells expressing an immune response-stimulating cytokine to attract and/or activate immune cells - Google Patents
Genetically modified mesenchymal stem cells expressing an immune response-stimulating cytokine to attract and/or activate immune cells Download PDFInfo
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| CN110527696A (zh) * | 2018-06-13 | 2019-12-03 | 中山大学 | 一种IFNβ和FerritinH基因联合修饰的骨髓间充质干细胞及其制备方法和应用 |
| CN108815188A (zh) * | 2018-07-06 | 2018-11-16 | 浙江生创精准医疗科技有限公司 | 包含间充质干细胞制剂与免疫检查点抑制剂的肿瘤治疗组合物、试剂盒及其用途 |
| CN112384231A (zh) * | 2018-08-26 | 2021-02-19 | 奥伊斯细胞生物技术公司 | 用于治疗胶质母细胞瘤的方法 |
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| CN113286874A (zh) * | 2018-10-12 | 2021-08-20 | 美商生物细胞基因治疗有限公司 | 嵌合抗原受体(CARs)组合物及使用方法 |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| JP2022512766A (ja) | 2018-10-17 | 2022-02-07 | センティ バイオサイエンシズ インコーポレイテッド | 組み合わせがん免疫療法 |
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| CN113795755A (zh) * | 2019-02-14 | 2021-12-14 | 全国儿童医院研究所 | 质膜颗粒、脂质体和外泌体用于测定免疫细胞效力的用途 |
| CN109762820B (zh) * | 2019-02-18 | 2020-07-28 | 河北佑仁生物科技有限公司 | 一种骨髓间充质干细胞特异性启动元件在干细胞中的应用 |
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| CN111849905B (zh) * | 2019-04-18 | 2023-03-24 | 上海交通大学 | 间充质干细胞靶向运输趋化因子和细胞因子的免疫疗法 |
| CN111139222B (zh) * | 2019-05-30 | 2020-12-29 | 北京双因生物科技有限公司 | 一种重组间充质干细胞及其制备方法和用途 |
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| WO2021194427A1 (en) * | 2020-03-26 | 2021-09-30 | Agency For Science, Technology And Research | A method and system for introducing one or more exogenous substances into an immune cell |
| KR20230018378A (ko) * | 2020-05-27 | 2023-02-07 | 유니버시타트 취리히 | 골수 세포 및 미세아교세포에서 치료 단백질을 특이적으로 발현하는 바이러스 벡터 |
| EP4183872A4 (en) * | 2020-07-16 | 2024-05-01 | Shanghai Jiaotong University | Immunotherapy method of targeted chemokine and cytokine delivery by mesenchymal stem cell |
| WO2022079322A1 (en) * | 2020-10-16 | 2022-04-21 | Fundació Centre De Regulació Genòmica | Therapy for degenerative disease and tissue damage |
| CN114507643A (zh) * | 2020-10-29 | 2022-05-17 | 未来智人再生医学研究院(广州)有限公司 | 一种表达il-2的多能干细胞衍生物及应用 |
| CN114426953A (zh) * | 2020-10-29 | 2022-05-03 | 未来智人再生医学研究院(广州)有限公司 | 一种表达il-12的多能干细胞衍生物及应用 |
| CN114717232A (zh) * | 2020-12-22 | 2022-07-08 | 未来智人再生医学研究院(广州)有限公司 | 表达irf-1靶向抑制因子的多能干细胞及其衍生物与应用 |
| WO2023274355A1 (zh) * | 2021-07-02 | 2023-01-05 | 上海交通大学 | 改造的间充质干细胞和免疫效应细胞联合治疗肿瘤 |
| US20230137723A1 (en) * | 2021-11-01 | 2023-05-04 | MAM Holdings of West Florida, L.L.C. | Mesenchymal stem cells for the prevention and targeted treatment of cancer and other disorders |
| CN114480413B (zh) * | 2022-01-14 | 2022-11-04 | 北京贝来生物科技有限公司 | 一种活化肿瘤免疫应答的基因修饰干细胞制备方法 |
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| CN117503952B (zh) * | 2022-11-24 | 2025-09-16 | 中国药科大学 | 一种基于血小板的免疫激活系统及其制备方法和应用 |
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| CA2956987A1 (en) | 2016-02-25 |
| US20200268802A1 (en) | 2020-08-27 |
| US20170239297A1 (en) | 2017-08-24 |
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| EP3656387A2 (en) | 2020-05-27 |
| CA2956987C (en) | 2023-03-21 |
| JP2017525364A (ja) | 2017-09-07 |
| IL250388A0 (en) | 2017-03-30 |
| US11464806B2 (en) | 2022-10-11 |
| EP3656387A3 (en) | 2020-07-01 |
| CN106659742B (zh) | 2021-09-03 |
| WO2016026854A3 (en) | 2016-04-14 |
| CN106659742A (zh) | 2017-05-10 |
| EP3182984B1 (en) | 2019-10-30 |
| IL250388B (en) | 2021-02-28 |
| WO2016026854A2 (en) | 2016-02-25 |
| EP3182984A2 (en) | 2017-06-28 |
| AU2015306231A1 (en) | 2017-02-23 |
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