AU2015301921A1 - Car-T lymphocytes engineered to home to lymph node B cell zone, skin, or gastrointestinal tract - Google Patents

Car-T lymphocytes engineered to home to lymph node B cell zone, skin, or gastrointestinal tract Download PDF

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Publication number
AU2015301921A1
AU2015301921A1 AU2015301921A AU2015301921A AU2015301921A1 AU 2015301921 A1 AU2015301921 A1 AU 2015301921A1 AU 2015301921 A AU2015301921 A AU 2015301921A AU 2015301921 A AU2015301921 A AU 2015301921A AU 2015301921 A1 AU2015301921 A1 AU 2015301921A1
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Prior art keywords
lymphocyte
homing receptor
skin
receptor
antigen
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Abandoned
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AU2015301921A
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English (en)
Inventor
Tianjian Li
Bitao Liang
Wei Liu
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Celgene Corp
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Celgene Corp
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Publication of AU2015301921A1 publication Critical patent/AU2015301921A1/en
Assigned to CELGENE CORPORATION reassignment CELGENE CORPORATION Request for Assignment Assignors: ANTHROGENESIS CORPORATION
Abandoned legal-status Critical Current

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61P17/00—Drugs for dermatological disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/22—Intracellular domain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/51—Stomach
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/57—Skin; melanoma
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/21—Chemokines, e.g. MIP-1, MIP-2, RANTES, MCP, PF-4
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
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    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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AU2015301921A 2014-08-12 2015-08-11 Car-T lymphocytes engineered to home to lymph node B cell zone, skin, or gastrointestinal tract Abandoned AU2015301921A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462036447P 2014-08-12 2014-08-12
US62/036,447 2014-08-12
PCT/US2015/044611 WO2016025454A2 (en) 2014-08-12 2015-08-11 Car-t lymphocytes engineered to home to lymph node b cell zone, skin, or gastrointestinal tract

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AU2015301921A1 true AU2015301921A1 (en) 2017-03-02

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AU2015301921A Abandoned AU2015301921A1 (en) 2014-08-12 2015-08-11 Car-T lymphocytes engineered to home to lymph node B cell zone, skin, or gastrointestinal tract

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US (2) US20180080008A1 (https=)
EP (2) EP3194579A4 (https=)
JP (3) JP2017524365A (https=)
KR (2) KR20220150428A (https=)
CN (1) CN106795497A (https=)
AU (1) AU2015301921A1 (https=)
CA (1) CA2957929A1 (https=)
NZ (1) NZ729046A (https=)
SG (1) SG11201701111SA (https=)
TW (2) TW201614072A (https=)
WO (1) WO2016025454A2 (https=)

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JP2017524365A (ja) 2017-08-31
KR20170045244A (ko) 2017-04-26
JP2021035366A (ja) 2021-03-04
NZ729046A (en) 2022-07-29
EP3194579A2 (en) 2017-07-26
WO2016025454A2 (en) 2016-02-18
CA2957929A1 (en) 2016-02-18
JP2023011593A (ja) 2023-01-24
KR20220150428A (ko) 2022-11-10
US20180080008A1 (en) 2018-03-22
EP3828267A2 (en) 2021-06-02
EP3194579A4 (en) 2018-04-04
CN106795497A (zh) 2017-05-31
TW201614072A (en) 2016-04-16
WO2016025454A3 (en) 2016-04-07
EP3828267A3 (en) 2021-08-11
TW202235619A (zh) 2022-09-16
SG11201701111SA (en) 2017-03-30
US20210254003A1 (en) 2021-08-19

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