JP2017524365A - リンパ節のｂ細胞領域、皮膚、または腸管にホーミングするように操作されたｃａｒ−ｔ細胞 - Google Patents

リンパ節のｂ細胞領域、皮膚、または腸管にホーミングするように操作されたｃａｒ−ｔ細胞 Download PDF

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JP2017524365A
JP2017524365A JP2017507842A JP2017507842A JP2017524365A JP 2017524365 A JP2017524365 A JP 2017524365A JP 2017507842 A JP2017507842 A JP 2017507842A JP 2017507842 A JP2017507842 A JP 2017507842A JP 2017524365 A JP2017524365 A JP 2017524365A
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cell
homing receptor
cells
skin
receptor
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JP2017524365A5 (ja
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リアング ビタオ
リアング ビタオ
リウ ウェイ
リウ ウェイ
リ ティアンジアン
リ ティアンジアン
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アントフロゲネシス コーポレーション
アントフロゲネシス コーポレーション
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JP2017507842A 2014-08-12 2015-08-11 リンパ節のｂ細胞領域、皮膚、または腸管にホーミングするように操作されたｃａｒ−ｔ細胞 Pending JP2017524365A (ja)

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US201462036447P 2014-08-12 2014-08-12
US62/036,447 2014-08-12
PCT/US2015/044611 WO2016025454A2 (en) 2014-08-12 2015-08-11 Car-t lymphocytes engineered to home to lymph node b cell zone, skin, or gastrointestinal tract

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JP2020173659A Division JP2021035366A (ja) 2014-08-12 2020-10-15 リンパ節のｂ細胞領域、皮膚、または消化管にホーミングするように操作されたｃａｒ−ｔ細胞

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JP2017507842A Pending JP2017524365A (ja) 2014-08-12 2015-08-11 リンパ節のｂ細胞領域、皮膚、または腸管にホーミングするように操作されたｃａｒ−ｔ細胞
JP2020173659A Pending JP2021035366A (ja) 2014-08-12 2020-10-15 リンパ節のｂ細胞領域、皮膚、または消化管にホーミングするように操作されたｃａｒ−ｔ細胞
JP2022161320A Pending JP2023011593A (ja) 2014-08-12 2022-10-06 リンパ節のｂ細胞領域、皮膚、または消化管にホーミングするように操作されたｃａｒ－ｔ細胞

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JP2022161320A Pending JP2023011593A (ja) 2014-08-12 2022-10-06 リンパ節のｂ細胞領域、皮膚、または消化管にホーミングするように操作されたｃａｒ－ｔ細胞

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US (2) US20180080008A1 (https=)
EP (2) EP3194579A4 (https=)
JP (3) JP2017524365A (https=)
KR (2) KR20220150428A (https=)
CN (1) CN106795497A (https=)
AU (1) AU2015301921A1 (https=)
CA (1) CA2957929A1 (https=)
NZ (1) NZ729046A (https=)
SG (1) SG11201701111SA (https=)
TW (2) TW201614072A (https=)
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020533981A (ja) * 2017-09-19 2020-11-26 中山大学 Ｃｘｃｒ５を過剰発現する間葉系幹細胞、その製造方法及び使用
JP2021509816A (ja) * 2018-01-08 2021-04-08 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド Ｃｄ９９−発現癌を標的にするための組成物および方法
JP2021530233A (ja) * 2018-07-18 2021-11-11 アムジエン・インコーポレーテツド Ｓｔｅａｐ１に対するキメラ受容体及びその使用方法

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2934532B1 (en) 2012-12-20 2019-10-23 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
AU2013204922B2 (en) 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
AU2014240083C1 (en) 2013-03-15 2019-10-24 Celgene Corporation Modified T lymphocytes
CN107995913B (zh) 2015-05-18 2022-02-11 T细胞受体治疗公司 使用融合蛋白对tcr重编程的组合物和方法
JP7282521B2 (ja) 2016-04-08 2023-05-29 パーデュー・リサーチ・ファウンデイション Ｃａｒ ｔ細胞療法のための方法および組成物
US11499168B2 (en) 2016-04-25 2022-11-15 Universitat Basel Allele editing and applications thereof
EP3494138A1 (en) 2016-08-02 2019-06-12 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
CA3036745A1 (en) 2016-10-07 2018-04-12 TCR2 Therapeutics Inc. Compositions and methods for t-cell receptors reprogramming using fusion proteins
WO2018075820A2 (en) 2016-10-20 2018-04-26 Celgene Corporation Cereblon-based heterodimerizable chimeric antigen receptors
US11851491B2 (en) 2016-11-22 2023-12-26 TCR2 Therapeutics Inc. Compositions and methods for TCR reprogramming using fusion proteins
AU2018223211B2 (en) * 2017-02-21 2025-02-27 Adelaide university T cells expressing chemokine receptors for treating cancer
JP7178355B2 (ja) 2017-02-28 2022-11-25 エンドサイト・インコーポレイテッド Ｃａｒ ｔ細胞療法のための組成物および方法
US11166985B2 (en) 2017-05-12 2021-11-09 Crispr Therapeutics Ag Materials and methods for engineering cells and uses thereof in immuno-oncology
MX2019013514A (es) 2017-05-12 2020-01-20 Crispr Therapeutics Ag Materiales y metodos para modificar celulas por ingenieria genetica y usos de los mismos en inmunooncologia.
US12384830B2 (en) 2017-06-02 2025-08-12 Regents Of The University Of Minnesota Compositions and methods for improving immunotherapy
CN107287207B (zh) * 2017-08-01 2019-02-26 上海优卡迪生物医药科技有限公司 一种用于体内示踪和人工清除car-t细胞的标签和应用
WO2019032699A1 (en) * 2017-08-09 2019-02-14 Eureka Therapeutics, Inc. CELLS EXPRESSING ANTIBODIES AND CELL SURFACE RECEPTORS
JP7549303B2 (ja) 2018-01-22 2024-09-11 エンドサイト・インコーポレイテッド Ｃａｒ ｔ細胞の使用方法
CN112105382A (zh) 2018-02-23 2020-12-18 恩多塞特公司 用于car t细胞疗法的顺序方法
US12227763B2 (en) 2018-05-11 2025-02-18 Crispr Therapeutics Ag Methods and compositions for treating cancer
WO2019241315A1 (en) 2018-06-12 2019-12-19 Obsidian Therapeutics, Inc. Pde5 derived regulatory constructs and methods of use in immunotherapy
CN109666074B (zh) * 2018-12-29 2020-04-24 广州百暨基因科技有限公司 一种趋化因子受体cxcr5的用途
WO2020182681A1 (en) * 2019-03-08 2020-09-17 Klinikum Der Universität München Ccr8 expressing lymphocytes for targeted tumor therapy
US20220249558A1 (en) 2019-04-30 2022-08-11 Crispr Therapeutics Ag Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005336062A (ja) * 2004-05-24 2005-12-08 Mitsubishi Chemicals Corp Ｔ細胞の腸組織へのホーミング誘導剤
WO2010003002A2 (en) * 2008-07-02 2010-01-07 Board Of Regents, The University Of Texas System Modulation of follicular helper t cells

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US5665577A (en) 1989-02-06 1997-09-09 Dana-Farber Cancer Institute Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
IL104570A0 (en) 1992-03-18 1993-05-13 Yeda Res & Dev Chimeric genes and cells transformed therewith
US8211422B2 (en) 1992-03-18 2012-07-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric receptor genes and cells transformed therewith
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
US5948893A (en) 1996-01-17 1999-09-07 The United States Of America As Represented By The Secretary Of The Navy Murine hybridoma and antibody binding to CD28 receptor secreted by the hybridoma and method of using the antibody
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
EP1849873B1 (en) 1999-04-29 2011-10-12 Gbp Ip, Llc Method and means for producing high titer, safe, recombinant lentivirus vectors
EP2316918B1 (en) 2001-02-14 2015-07-01 Anthrogenesis Corporation Post-partum mammalian placenta, its use and placental stem cells therefrom
US20070155663A1 (en) * 2003-03-24 2007-07-05 Rudolf Richter Use of chemokine receptor agonists for stem cell transplantation
PL2471907T3 (pl) 2005-12-29 2019-07-31 Celularity, Inc. Populacje komórek macierzystych łożyska
JP6850528B2 (ja) * 2012-02-13 2021-03-31 シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート 二重特異性キメラ抗原受容体およびその治療的使用
CN104411819B (zh) * 2012-06-11 2019-05-10 威尔逊沃夫制造公司 用于过继细胞疗法的改进的细胞培养方法
CN103483452B (zh) * 2012-06-12 2021-08-13 上海细胞治疗集团有限公司 双信号独立的嵌合抗原受体及其用途
EP2893003B1 (en) * 2012-09-04 2021-03-31 Inven2 AS Selective and controlled expansion of educated nk cells
US9393268B2 (en) * 2013-03-15 2016-07-19 Thomas Jefferson University Cell-based anti-cancer compositions with reduced toxicity and methods of making and using the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005336062A (ja) * 2004-05-24 2005-12-08 Mitsubishi Chemicals Corp Ｔ細胞の腸組織へのホーミング誘導剤
WO2010003002A2 (en) * 2008-07-02 2010-01-07 Board Of Regents, The University Of Texas System Modulation of follicular helper t cells

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BLOOD, 2009, 113(25);6392-6402, JPN6019025250, ISSN: 0004283034 *
BLOOD, 2010, 116(7):1035-1044, JPN6019025252, ISSN: 0004283035 *
CANCER J., 2014, 20(2):127-133, JPN6019025261, ISSN: 0004283038 *
CLIN. CACNER RES., 2011, 17(14):4719-4730, JPN6019025258, ISSN: 0004283037 *
INT J HEMATOL., 2014 APR, 99(4):361-371, JPN6020019568, ISSN: 0004283041 *
J. IMMUNOTHER., 2010, 33(8):780-788, JPN6019025254, ISSN: 0004283036 *
JPN. J. CLINI. IMMUNOL., 2013, 36(4):189-196, JPN6019025265, ISSN: 0004283040 *
NATURE IMMUNOL., 2007, 8(3):285-293, JPN6019025264, ISSN: 0004283039 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020533981A (ja) * 2017-09-19 2020-11-26 中山大学 Ｃｘｃｒ５を過剰発現する間葉系幹細胞、その製造方法及び使用
JP2021509816A (ja) * 2018-01-08 2021-04-08 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド Ｃｄ９９−発現癌を標的にするための組成物および方法
JP7281824B2 (ja) 2018-01-08 2023-05-26 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド Ｃｄ９９－発現癌を標的にするための組成物および方法
US12036273B2 (en) 2018-01-08 2024-07-16 H. Lee Moffitt Cancer Center And Research Institute, Inc. Compositions and methods for targeting CD99-expressing cancers
JP2021530233A (ja) * 2018-07-18 2021-11-11 アムジエン・インコーポレーテツド Ｓｔｅａｐ１に対するキメラ受容体及びその使用方法
JP7459046B2 (ja) 2018-07-18 2024-04-01 アムジエン・インコーポレーテツド Ｓｔｅａｐ１に対するキメラ受容体及びその使用方法

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