TW201614072A - CAR-T lymphocytes engineered to home to lymph node B cell zone, skin, or gastrointestinal tract - Google Patents

CAR-T lymphocytes engineered to home to lymph node B cell zone, skin, or gastrointestinal tract

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Publication number
TW201614072A
TW201614072A TW104126314A TW104126314A TW201614072A TW 201614072 A TW201614072 A TW 201614072A TW 104126314 A TW104126314 A TW 104126314A TW 104126314 A TW104126314 A TW 104126314A TW 201614072 A TW201614072 A TW 201614072A
Authority
TW
Taiwan
Prior art keywords
home
skin
gastrointestinal tract
car
lymph node
Prior art date
Application number
TW104126314A
Other languages
English (en)
Inventor
Bitao Liang
Wei Liu
Tianjian Li
Original Assignee
Anthrogenesis Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anthrogenesis Corp filed Critical Anthrogenesis Corp
Publication of TW201614072A publication Critical patent/TW201614072A/zh

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001129—Molecules with a "CD" designation not provided for elsewhere
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00118—Cancer antigens from embryonic or fetal origin
    • A61K39/001182—Carcinoembryonic antigen [CEA]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/70546—Integrin superfamily
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    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C07K16/3007—Carcino-embryonic Antigens
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/22—Intracellular domain
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/51—Stomach
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/57—Skin; melanoma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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TW104126314A 2014-08-12 2015-08-12 CAR-T lymphocytes engineered to home to lymph node B cell zone, skin, or gastrointestinal tract TW201614072A (en)

Applications Claiming Priority (1)

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US201462036447P 2014-08-12 2014-08-12

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TW201614072A true TW201614072A (en) 2016-04-16

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TW110145417A TW202235619A (zh) 2014-08-12 2015-08-12 經改造以回歸至淋巴結b細胞區、皮膚或腸胃道之car-t淋巴球
TW104126314A TW201614072A (en) 2014-08-12 2015-08-12 CAR-T lymphocytes engineered to home to lymph node B cell zone, skin, or gastrointestinal tract

Family Applications Before (1)

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TW110145417A TW202235619A (zh) 2014-08-12 2015-08-12 經改造以回歸至淋巴結b細胞區、皮膚或腸胃道之car-t淋巴球

Country Status (11)

Country Link
US (2) US20180080008A1 (zh)
EP (2) EP3828267A3 (zh)
JP (3) JP2017524365A (zh)
KR (2) KR20220150428A (zh)
CN (1) CN106795497A (zh)
AU (1) AU2015301921A1 (zh)
CA (1) CA2957929A1 (zh)
NZ (1) NZ729046A (zh)
SG (1) SG11201701111SA (zh)
TW (2) TW202235619A (zh)
WO (1) WO2016025454A2 (zh)

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US20180080008A1 (en) 2018-03-22
CN106795497A (zh) 2017-05-31
AU2015301921A1 (en) 2017-03-02
TW202235619A (zh) 2022-09-16
NZ729046A (en) 2022-07-29
JP2021035366A (ja) 2021-03-04
CA2957929A1 (en) 2016-02-18
JP2023011593A (ja) 2023-01-24
EP3194579A4 (en) 2018-04-04
WO2016025454A2 (en) 2016-02-18
WO2016025454A3 (en) 2016-04-07
SG11201701111SA (en) 2017-03-30
KR20170045244A (ko) 2017-04-26
US20210254003A1 (en) 2021-08-19
EP3194579A2 (en) 2017-07-26
JP2017524365A (ja) 2017-08-31
EP3828267A3 (en) 2021-08-11
KR20220150428A (ko) 2022-11-10

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