AU2015289999B2 - Systems and methods for improved performance of fluidic and microfluidic systems - Google Patents

Systems and methods for improved performance of fluidic and microfluidic systems Download PDF

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AU2015289999B2
AU2015289999B2 AU2015289999A AU2015289999A AU2015289999B2 AU 2015289999 B2 AU2015289999 B2 AU 2015289999B2 AU 2015289999 A AU2015289999 A AU 2015289999A AU 2015289999 A AU2015289999 A AU 2015289999A AU 2015289999 B2 AU2015289999 B2 AU 2015289999B2
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fluid
microchannel
resistance element
resistance
elongated
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AU2015289999A1 (en
AU2015289999A2 (en
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Jose FERNANDEZ-ALCON
Hubert GEISLER
Christopher David HINOJOSA
Donald E. Ingber
Daniel Levner
Josiah SLIZ
Guy Thompson
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Harvard University
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Harvard University
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/12—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/08—Chemical, biochemical or biological means, e.g. plasma jet, co-culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L2300/14—Means for pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

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  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
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  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Sustainable Development (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Nanotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
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  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
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  • Micromachines (AREA)
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AU2015289999A 2014-07-14 2015-07-10 Systems and methods for improved performance of fluidic and microfluidic systems Active AU2015289999B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462024361P 2014-07-14 2014-07-14
US62/024,361 2014-07-14
US201562127438P 2015-03-03 2015-03-03
US62/127,438 2015-03-03
PCT/US2015/040026 WO2016010861A1 (en) 2014-07-14 2015-07-10 Systems and methods for improved performance of fluidic and microfluidic systems

Publications (3)

Publication Number Publication Date
AU2015289999A1 AU2015289999A1 (en) 2017-03-09
AU2015289999A2 AU2015289999A2 (en) 2017-03-16
AU2015289999B2 true AU2015289999B2 (en) 2020-09-10

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AU2015289999A Active AU2015289999B2 (en) 2014-07-14 2015-07-10 Systems and methods for improved performance of fluidic and microfluidic systems

Country Status (7)

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US (4) US11434458B2 (enExample)
EP (1) EP3169626A4 (enExample)
JP (2) JP6815985B2 (enExample)
AU (1) AU2015289999B2 (enExample)
CA (1) CA2955172C (enExample)
GB (1) GB2546424A (enExample)
WO (1) WO2016010861A1 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016071691A1 (en) * 2014-11-07 2016-05-12 Oxy Solutions As Apparatus for dissolving gas into a liquid
GB2555948A (en) * 2015-03-04 2018-05-16 Harvard College Fluidic device for quantifying the dynamic permeability and hydraulic conductivity of living tissue layers
US10179896B2 (en) 2015-05-12 2019-01-15 Baker Group, LLP Method and system for a bioartificial organ
EP4026616B1 (en) 2015-08-26 2024-12-11 Emulate, Inc. Perfusion manifold assembly
EP3439783A1 (en) * 2016-04-06 2019-02-13 Fluidic Analytics Limited Improvements in or relating to flow balancing
WO2017192098A1 (en) * 2016-05-04 2017-11-09 Clearbridge Biomedics Pte Ltd Systems and methods for enriching target cells in a sample
USD812766S1 (en) * 2016-07-12 2018-03-13 EMULATE, Inc. Microfluidic chip for use with a fluid perfusion module
US10335788B2 (en) * 2016-07-12 2019-07-02 EMULATE, Inc. Removing bubbles in a microfluidic device
NL2017227B1 (en) 2016-07-25 2018-01-31 Univ Delft Tech Versatile 3D Stretchable Micro-Environment for Organ-on-Chip Devices Fabricated with Standard Silicon Technology
GB2553519B (en) * 2016-09-02 2019-12-18 Fluidic Analytics Ltd Improvements in or relating to a fluid flow controller for microfluidic devices
USD842493S1 (en) * 2016-09-07 2019-03-05 EMULATE, Inc. Microfluidic chip without pressure features for use with a fluid perfusion module
USD838864S1 (en) * 2016-09-07 2019-01-22 EMULATE, Inc. Opaque microfluidic chip without pressure features for use with a fluid perfusion module
USD803173S1 (en) * 2016-09-07 2017-11-21 EMULATE, Inc. Perfusion module lid without pressure features
USD816861S1 (en) * 2016-09-07 2018-05-01 EMULATE, Inc. Transparent microfluidic chip without pressure features for use with a fluid perfusion module
US11001796B2 (en) 2016-11-23 2021-05-11 The Charles Stark Draper Laboratory, Inc. Bi-layer multi-well cell culture platform
WO2018151726A1 (en) * 2017-02-16 2018-08-23 Hewlett-Packard Development Company, L.P. Bubble valve
GB2608510B (en) * 2017-03-24 2023-04-05 Harvard College Bone marrow microfluidic devices and methods for preparing and using the same
EP3638021B1 (en) * 2017-06-14 2025-01-22 University of Louisville Research Foundation Methods for preservation of cells
SG11201912152PA (en) * 2017-06-14 2020-01-30 Emulate Inc Effects of space travel on human brain cells
GB2578989B (en) 2017-07-12 2021-06-16 Emulate Inc Surface functionalization
CN111971112A (zh) 2018-01-29 2020-11-20 因塔生物公司 用于样品表征的装置、方法和试剂盒
BR102018004973B1 (pt) * 2018-03-13 2021-10-13 Petróleo Brasileiro S.A. - Petrobras Dispositivo e método para rompimento de células de microorganismos por extrusão
EP3875574B1 (en) * 2018-10-29 2023-07-05 NOK Corporation Micro-fluid chip and micro-fluid device
US12128408B2 (en) 2019-08-06 2024-10-29 Bio-Rad Laboratories Inc. Structures on microfluidic devices to control sedimentation
US11458467B2 (en) 2019-08-06 2022-10-04 Bio-Rad Laboratories Inc. Structures to define flow confinement shape and confinement stability with uniform aspiration
US11130125B2 (en) 2019-08-06 2021-09-28 Bio-Rad Laboratories, Inc. Prevention and bubble removal from microfluidic devices
US11285484B2 (en) 2019-08-12 2022-03-29 Intabio, Llc Multichannel isoelectric focusing devices and high voltage power supplies
CN110787851B (zh) * 2019-10-25 2020-12-04 浙江大学 基于压力驱动的多通道液滴定量量取装置与量取方法
NL2025441B1 (en) 2020-04-28 2021-11-09 Biond Solutions B V All-in-one microchamber for 3D muscular tissues
WO2022010849A2 (en) * 2020-07-07 2022-01-13 Cam Med Inc. Infusion pump
NL2026640B1 (en) 2020-10-07 2022-06-08 Lumicks Ca Holding B V System and method for loading a microfluidic chip
EP4291630A1 (en) * 2021-02-12 2023-12-20 The Charles Stark Draper Laboratory, Inc. Microchannel cell culture device and system
US12252678B2 (en) 2021-12-01 2025-03-18 Microfluidx Ltd Systems and methods for bioprocessing
EP4245839A1 (en) * 2022-03-14 2023-09-20 Fluigent Method for monitoring at least one substance produced or consumed by a living entity
JP2024008492A (ja) * 2022-07-08 2024-01-19 株式会社日立製作所 送液方法、流路デバイスおよび送液装置

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6500151B1 (en) * 1999-04-28 2002-12-31 Smiths Group Plc Syringe pump
WO2009157863A1 (en) * 2008-06-26 2009-12-30 Wigstroem Joakim Microfluidic device
US20110120871A1 (en) * 2007-12-19 2011-05-26 Stuart William Reid Formation of Layers of Amphiphilic Molecules
US20110250585A1 (en) * 2008-07-16 2011-10-13 Children's Medical Center Corporation Organ mimic device with microchannels and methods of use and manufacturing thereof

Family Cites Families (164)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1301897A (fr) 1961-07-10 1962-08-24 Procédé de sélection d'émulsions destinées à la préparation de produits cosmétiques et dermatologiques
US3313290A (en) 1963-08-14 1967-04-11 Research Corp Spectrofluorometer
US3722504A (en) 1969-12-23 1973-03-27 P Sawyer Method of screening substances for use in the treatment of circulatory system diseases
US3941662A (en) 1971-06-09 1976-03-02 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Apparatus for culturing cells
US3948732A (en) 1973-05-31 1976-04-06 Instrumentation Laboratory, Inc. Cell culture assembly
DE2726313C3 (de) 1977-06-10 1980-02-07 Battelle-Institut E.V., 6000 Frankfurt Verfahren zur in-vitro-Biosynthese von Hormonen, insbesondere von Insulin
CH651587A5 (de) 1980-11-18 1985-09-30 Chemap Ag Verfahren und vorrichtung zur submersen zuechtung von zellkulturen.
US4436824A (en) 1981-06-09 1984-03-13 Ortho Diagnostic Systems, Inc. Leukocyte migration through antigen containing agaroses for immunocompetence testing
US4629686A (en) 1982-02-19 1986-12-16 Endotronics, Inc. Apparatus for delivering a controlled dosage of a chemical substance
US4537860A (en) 1982-12-08 1985-08-27 Monsanto Company Static cell culture maintenance system
US4446229A (en) 1982-12-30 1984-05-01 Indech Robert B Method of tissue growth
US4734372A (en) 1983-02-04 1988-03-29 Brown University Research Foundation Cell culturing methods and apparatus
US4610878A (en) 1983-06-16 1986-09-09 Medical University Of South Carolina Use of in vitro assay techniques to measure parameters related to clinical applications of transfer factor therapy
NL8401221A (nl) 1984-04-16 1985-11-18 Innovi Nv Analytische toepassing van fagocyt-cellijnen.
US4650766A (en) 1984-10-09 1987-03-17 Endotronics, Inc. Culturing apparatus
US4720462A (en) 1985-11-05 1988-01-19 Robert Rosenson Culture system for the culture of solid tissue masses and method of using the same
US4673650A (en) 1986-03-28 1987-06-16 Damon Biotech, Inc. Protein harvesting system
US5160490A (en) 1986-04-18 1992-11-03 Marrow-Tech Incorporated Three-dimensional cell and tissue culture apparatus
US5316905A (en) 1986-09-29 1994-05-31 Suzuki Shokan Co., Ltd. Culture medium supplying method and culture system
US4835102A (en) 1987-03-31 1989-05-30 Eugene Bell Tissue equivalent test systems
US4839280A (en) 1987-05-04 1989-06-13 Banes Albert J Apparatus for applying stress to cell cultures
US5108926A (en) 1987-09-08 1992-04-28 Board Of Regents, The University Of Texas System Apparatus for the precise positioning of cells
US4929542A (en) 1987-10-30 1990-05-29 Cornell Research Foundation, Inc. In vitro screening test for mutagenicity and genotoxicity during spermatogenesis
US5043260A (en) 1987-11-02 1991-08-27 Rhode Island Hospital Perfusion device with hepatocytes
US4851354A (en) 1987-12-07 1989-07-25 Trustees Of The University Of Pennsylvania Apparatus for mechanically stimulating cells
US4940853A (en) 1988-07-22 1990-07-10 Vandenburgh Herman H Method for growing tissue specimens in vitro
EP0394406B1 (en) 1988-10-21 1995-04-26 Molecular Devices Corporation Methods and apparatus for detecting the effect of cell affecting agents on living cells
US5002890A (en) 1988-11-29 1991-03-26 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Spiral vane bioreactor
WO1991018087A1 (en) 1990-05-16 1991-11-28 Baylor College Of Medicine A permanent human hepatocyte cell line and its use in a liver assist device (lad)
US5217899A (en) 1990-08-24 1993-06-08 The General Hospital Corporation Cell stretching apparatus
DE4116727C2 (de) 1991-05-17 1995-09-07 Uwe Dr Marx Verfahren und Vorrichtung zur gleichzeitigen Kultivierung unterschiedlicher Säugerzellen
US5197575A (en) 1991-10-29 1993-03-30 Mangum U Stancel Small vehicle braking system
US5612188A (en) 1991-11-25 1997-03-18 Cornell Research Foundation, Inc. Automated, multicompartmental cell culture system
GB9204128D0 (en) 1992-02-26 1992-04-08 Jessop Richard V Improvements in or relating to a toy or educational device
US5744366A (en) 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5486335A (en) 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5900160A (en) 1993-10-04 1999-05-04 President And Fellows Of Harvard College Methods of etching articles via microcontact printing
US5695996A (en) 1994-09-23 1997-12-09 The United States Of America As Represented By The Department Of Health And Human Services Artificial organ culture system
US7008634B2 (en) 1995-03-03 2006-03-07 Massachusetts Institute Of Technology Cell growth substrates with tethered cell growth effector molecules
US5820769A (en) 1995-05-24 1998-10-13 Regents Of The University Of Minnesota Method for making magnetic storage having discrete elements with quantized magnetic moments
US6054277A (en) 1996-05-08 2000-04-25 Regents Of The University Of Minnesota Integrated microchip genetic testing system
CA2217266A1 (en) 1997-05-14 1998-11-14 The General Hospital Corporation Co-cultivation of cells in a micropatterned configuration
CA2307567C (en) 1997-10-31 2009-01-20 Children's Medical Center Corporation Polymer matrix/cell construct for bladder reconstruction
US6048723A (en) 1997-12-02 2000-04-11 Flexcell International Corporation Flexible bottom culture plate for applying mechanical load to cell cultures
ATE227338T1 (de) 1998-03-18 2002-11-15 Massachusetts Inst Technology Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
US6472202B1 (en) 1998-05-08 2002-10-29 Flexcell International Corporation Loading station assembly and method for tissue engineering
AT407047B (de) 1998-08-03 2000-11-27 Pfaller Walter Dr Zellkulturvorrichtung
US6586235B1 (en) 1998-12-04 2003-07-01 Flexcell International Corporation Apparatus for growing cells in culture under shear stress and/or strain
US6645759B2 (en) 1998-12-04 2003-11-11 Flexcell International Corporation Apparatus for growing cells in culture under shear stress and/or strain
US7759113B2 (en) 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
US6562616B1 (en) 1999-06-21 2003-05-13 The General Hospital Corporation Methods and devices for cell culturing and organ assist systems
US7244402B2 (en) * 2001-04-06 2007-07-17 California Institute Of Technology Microfluidic protein crystallography
US6858185B1 (en) * 1999-08-25 2005-02-22 Caliper Life Sciences, Inc. Dilutions in high throughput systems with a single vacuum source
US6530370B1 (en) 1999-09-16 2003-03-11 Instrumentation Corp. Nebulizer apparatus
AU2001249071B2 (en) * 2000-02-23 2005-09-08 Caliper Life Sciences, Inc. Multi-reservoir pressure control system
AU3986501A (en) 2000-02-23 2001-09-03 Zyomyx Inc Chips having elevated sample surfaces
EP1336097A4 (en) 2000-10-13 2006-02-01 Fluidigm Corp SAMPLE INJECTION SYSTEM BASED ON A MICROFLUIDIC EQUIPMENT FOR ANALYTICAL EQUIPMENT
US6653124B1 (en) 2000-11-10 2003-11-25 Cytoplex Biosciences Inc. Array-based microenvironment for cell culturing, cell monitoring and drug-target validation
WO2002046365A2 (en) 2000-12-08 2002-06-13 Flexcell International Corporation Method and apparatus to grow and mechanically condition cell cultures
US6546927B2 (en) 2001-03-13 2003-04-15 Aerogen, Inc. Methods and apparatus for controlling piezoelectric vibration
US7314718B1 (en) 2001-04-03 2008-01-01 Bioarray Solutions Ltd. Method and apparatus for maintaining multiple planar fluid flows
US20040132166A1 (en) 2001-04-10 2004-07-08 Bioprocessors Corp. Determination and/or control of reactor environmental conditions
US7288405B2 (en) 2001-04-25 2007-10-30 Cornell Research Foundation, Inc. Devices and methods for pharmacokinetic-based cell culture system
US20070037277A1 (en) 2001-04-25 2007-02-15 Michael Shuler Pharmacokinetic-based culture system with biological barriers
US20070048727A1 (en) 2001-04-25 2007-03-01 Michael Shuler Biliary barrier
AU2002257289A1 (en) 2001-05-17 2002-11-25 The Board Of Trustees Of The Leland Stanford Junior University Device and method for three-dimensional spatial localization and functional interconnection of different types of cells
US7318912B2 (en) 2001-06-07 2008-01-15 Nanostream, Inc. Microfluidic systems and methods for combining discrete fluid volumes
JP2005501011A (ja) 2001-06-08 2005-01-13 ユタ ベンチャー ザ セカンド リミテッド パートナーシップ 組織特異的内皮膜タンパク質
US7704728B2 (en) 2001-07-18 2010-04-27 The University Of Michigan Microfluidic gravity pump with constant flow rate
US6630801B2 (en) 2001-10-22 2003-10-07 Lümileds USA Method and apparatus for sensing the color point of an RGB LED white luminary using photodiodes
EP1448247B1 (en) 2001-11-16 2011-02-16 Children's Medical Center Corporation Creation of tissue engineered female reproductive organs
US6921253B2 (en) 2001-12-21 2005-07-26 Cornell Research Foundation, Inc. Dual chamber micropump having checkvalves
AU2003205241A1 (en) 2002-01-22 2003-09-02 The Penn State Research Foundation Drug candidate screening systems based on micropatterned hydrogels and microfluidic systems
DE60317305T2 (de) * 2002-01-25 2008-08-28 Innovadyne Technologies, Inc., Santa Rosa Kontaktloses verfahren zur verteilung geringer flüssigkeitsmengen
WO2004006840A2 (en) 2002-07-12 2004-01-22 The Regents Of The University Of California Three dimensional cell patterned bioploymer scaffolds and method of making the same
US7790443B2 (en) 2002-08-27 2010-09-07 Vanderbilt University Bioreactors with substance injection capacity
AU2003268202A1 (en) 2002-08-27 2004-03-19 Vanderbilt University Bioreactors with an array of chambers and a common feed line
AU2003275140A1 (en) 2002-09-23 2004-04-08 Massachusetts Institute Of Technology Theree-dimensional construct for the design and fabrication of physiological fluidic networks
AU2003283663A1 (en) * 2002-11-01 2004-05-25 Cellectricon Ab Computer programs,workstations, systems and methods for microfluidic substrates in cell
DE602004022508D1 (de) 2003-01-16 2009-09-24 Gen Hospital Corp Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen
US20060263336A1 (en) 2003-03-24 2006-11-23 Caplan Arnold I Cell targeting methods and compositions
WO2004094586A2 (en) 2003-04-18 2004-11-04 Carnegie Mellon University Three-dimentional, flexible cell growth substrate and related methods
US7960166B2 (en) 2003-05-21 2011-06-14 The General Hospital Corporation Microfabricated compositions and processes for engineering tissues containing multiple cell types
US20050032205A1 (en) 2003-08-05 2005-02-10 Smith Sidney T. In vitro cell culture employing a fibrin network in a flexible gas permeable container
US20050266393A1 (en) 2003-10-01 2005-12-01 Baxter Gregory T Circulating flow device for assays of cell cultures, cellular components and cell products
EP1548031A1 (en) 2003-12-22 2005-06-29 Dubai Genetics FZ-LLC Nature-identical erythropoietin
US8030057B2 (en) * 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
JP2007537759A (ja) 2004-05-19 2007-12-27 マサチューセッツ・インスティテュート・オブ・テクノロジー 灌流三次元細胞／組織疾患モデル
CA2500747A1 (en) 2004-06-14 2005-12-14 University Technologies International Inc. Microfluidic device with electrode structures
EP1793865A4 (en) 2004-08-05 2009-05-13 Baylor Res Inst GENETIC OR DRUG DELIVERY SYSTEM
US20070243627A1 (en) 2004-09-30 2007-10-18 Shuichi Takayama Computerized control method and system for microfluidics and computer program product for use therein
WO2006052223A1 (en) 2004-11-11 2006-05-18 Agency For Science, Technology And Research Cell culture device
AU2006249574B2 (en) 2005-05-25 2012-01-19 Novartis Ag Vibration systems and methods
US8257964B2 (en) 2006-01-04 2012-09-04 Cell ASIC Microwell cell-culture device and fabrication method
US9637715B2 (en) 2005-07-07 2017-05-02 Emd Millipore Corporation Cell culture and invasion assay method and system
US9388374B2 (en) 2005-07-07 2016-07-12 Emd Millipore Corporation Microfluidic cell culture systems
US7745209B2 (en) 2005-07-26 2010-06-29 Corning Incorporated Multilayered cell culture apparatus
US7790028B1 (en) 2005-09-28 2010-09-07 The Charles Stark Draper Laboratory, Inc. Systems, methods, and devices relating to a cellularized nephron unit
US9220831B2 (en) 2005-10-06 2015-12-29 Children's Medical Center Corporation Device and method for combined microfluidic-micromagnetic separation of material in continuous flow
US20070090166A1 (en) 2005-10-18 2007-04-26 Shuichi Takayama Microfluidic cell culture device
US7964078B2 (en) 2005-11-07 2011-06-21 The Regents Of The University Of California Microfluidic device for cell and particle separation
US20070172943A1 (en) 2005-11-07 2007-07-26 Robert Freedman Devices and methods for culturing, preserving, transporting, storing, reconstituting and assaying cellular materials
US7802569B2 (en) 2005-12-22 2010-09-28 Kaer Biotherapeutics Corporation Aerosol processing and inhalation method and system for high dose rate aerosol drug delivery
US7976795B2 (en) 2006-01-19 2011-07-12 Rheonix, Inc. Microfluidic systems
US8609039B2 (en) * 2006-01-19 2013-12-17 Rheonix, Inc. Microfluidic systems and control methods
KR20070077320A (ko) 2006-01-23 2007-07-26 삼성전자주식회사 세포 배양을 실시간으로 모니터링 가능한 세포 배양 칩 및그를 이용한 세포 배양 모니터링 방법
US7622298B2 (en) 2006-03-24 2009-11-24 Norits, Inc. Method for creating perfusable microvessel systems
US9023642B2 (en) 2006-07-07 2015-05-05 The University Of Houston System Method and apparatus for a miniature bioreactor system for long-term cell culture
US7854902B2 (en) * 2006-08-23 2010-12-21 Nanotek, Llc Modular and reconfigurable multi-stage high temperature microreactor cartridge apparatus and system for using same
US20080064088A1 (en) 2006-09-08 2008-03-13 Michael Shuler Devices and methods for pharmacokinetic-based cell culture system
FR2905690B1 (fr) 2006-09-12 2008-10-17 Saint Gobain Procede de fabrication d'un dispositif microfluidique.
EP2069068A2 (en) 2006-09-28 2009-06-17 The University of Washington 3d micro-scale engineered tissue model systems
WO2008086477A1 (en) 2007-01-10 2008-07-17 The Regents Of The University Of Michigan Ultrafiltration membrane, device, bioartificial organ, and related methods
WO2008118098A1 (en) * 2007-03-26 2008-10-02 Agency For Science, Technology And Research Fluid cartridge, pump and fluid valve arrangement
US8343740B2 (en) 2007-03-29 2013-01-01 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Micro-organ device
WO2008130618A1 (en) 2007-04-19 2008-10-30 The Charles Stark Draper Laboratory, Inc. Method and apparatus for separating particles, cells, molecules and particulates
US20080318334A1 (en) 2007-06-20 2008-12-25 Robotti Karla M Microfluidic devices comprising fluid flow paths having a monolithic chromatographic material
KR20090030084A (ko) 2007-09-19 2009-03-24 삼성전자주식회사 미세유동장치
JP5013424B2 (ja) * 2007-10-26 2012-08-29 独立行政法人産業技術総合研究所 マイクロチップ、マスターチップ
US20100041128A1 (en) 2008-01-08 2010-02-18 Medtrain Technologies, Llc Microfluidic Device for Application of Shear Stress and Tensile Strain
CN101939644B (zh) 2008-01-10 2014-06-11 休雷尔公司 免疫系统模拟装置和方法
WO2009102751A2 (en) 2008-02-11 2009-08-20 The General Hospital Corporation System and method for in vitro blood vessel modeling
KR100952056B1 (ko) 2008-02-29 2010-04-07 아주대학교산학협력단 기계적 자극에 대한 줄기세포 분화의 최적의 조건을 검출할수 있는 셀-칩 및 이의 자동 제어 시스템
DE102008018170B4 (de) 2008-04-03 2010-05-12 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Mikrofluidisches System und Verfahren zum Aufbau und zur anschließenden Kultivierung sowie nachfolgender Untersuchung von komplexen Zellanordnungen
US7999937B1 (en) * 2008-05-13 2011-08-16 Sandia Corporation Microfluidic devices and methods for integrated flow cytometry
CN102257124B (zh) 2008-06-04 2014-12-03 蒂斯由斯股份有限公司 芯片上器官装置
EP2294409B1 (en) 2008-06-17 2016-08-10 The Governing Council Of The University Of Toronto Device for investigation of a flow conduit
WO2010024779A1 (en) 2008-08-27 2010-03-04 Agency For Science, Technology And Research Microfluidic continuous flow device for culturing biological material
WO2010023497A1 (en) 2008-08-29 2010-03-04 Peking University A microfluidic chip for accurately controllable cell culture
WO2010101708A2 (en) 2009-03-04 2010-09-10 University Of Maine System Board Of Trustees Microfluidic device and related methods
US20100294986A1 (en) 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Supercritical fluid facilitated particle formation in microfluidic systems
US9180263B2 (en) 2009-07-01 2015-11-10 Microdose Therapeutx, Inc. Laboratory animal pulmonary dosing device
US8748180B2 (en) 2009-07-29 2014-06-10 Cornell University Microfluidic device for pharmacokinetic-pharmacodynamic study of drugs and uses thereof
US8757189B2 (en) 2010-01-27 2014-06-24 The United States Of America, As Represented By The Secretary Of Commerce Fluid delivery system
WO2012034022A2 (en) 2010-09-10 2012-03-15 Solidus Biosciences, Inc. Microarray cell chip
EP2490005A1 (en) 2011-02-18 2012-08-22 Koninklijke Philips Electronics N.V. Microfluidic resistance network and microfluidic device
CA2828110C (en) 2011-02-28 2020-03-31 President And Fellows Of Harvard College Cell culture system
US20140199764A1 (en) 2011-05-09 2014-07-17 President And Fellows Of Harvard College Microfluidic module and uses thereof
US20140158233A1 (en) 2011-05-09 2014-06-12 President And Fellows Of Harvard College Aerosol delivery to a microfluidic device
EP2714892B1 (en) 2011-06-02 2018-02-21 President and Fellows of Harvard College Methods and uses for ex vivo tissue culture systems
CA2839435C (en) 2011-06-15 2021-05-11 The Charles Stark Draper Laboratory, Inc. Systems, methods, and devices relating to a biomimetic cellularized nephron unit
JP2014516582A (ja) 2011-06-15 2014-07-17 ザ チャールズ スターク ドレイパー ラボラトリー インク 生体模倣環境において細胞を培養するためのデバイスおよび方法
CA2840126A1 (en) * 2011-07-04 2013-01-10 National Research Council Of Canada Centrifugal microfluidic platform
PL221042B1 (pl) * 2011-07-27 2016-02-29 Inst Chemii Fizycznej Polskiej Akademii Nauk Urządzenie i sposób do wysokoprzepustowego tworzenia i łączenia kropli na żądanie
WO2013089883A2 (en) * 2011-09-30 2013-06-20 The Regents Of The University Of California Devices and methods for shape-based particle separation
EP2785825B1 (en) * 2011-12-03 2021-04-21 EMD Millipore Corporation Microfluidic cell culture system
US20140335496A1 (en) * 2011-12-05 2014-11-13 Research Triangle Institute Human conducting airway model comprising multiple fluidic pathways
WO2013086486A1 (en) 2011-12-09 2013-06-13 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
WO2013086502A1 (en) 2011-12-09 2013-06-13 President And Fellows Of Harvard College Organ chips and uses thereof
US11001797B2 (en) 2012-04-13 2021-05-11 President And Fellows Of Harvard College Devices and methods for in vitro aerosol delivery
WO2014039514A2 (en) * 2012-09-05 2014-03-13 President And Fellows Of Harvard College Removing bubbles in microfluidic systems
WO2014039517A1 (en) 2012-09-05 2014-03-13 Newlans, Inc. Bi-quad calibration
WO2014133624A2 (en) 2012-12-10 2014-09-04 President And Fellows Of Harvard College Membrane-based fluid-flow control devices
CA2896997C (en) * 2013-01-03 2023-10-03 Brigham And Women's Hospital, Inc. System and method for a biomimetic fluid processing
GB2515116A (en) 2013-06-14 2014-12-17 Univ Dublin City Microfluidic Device
WO2014210364A2 (en) 2013-06-26 2014-12-31 President And Fellows Of Harvard College Interconnect adaptor
AU2014287013B2 (en) 2013-07-12 2020-01-23 President And Fellows Of Harvard College Systems and methods for cell culture device interconnection and fluidic device interconnection
US9855554B2 (en) 2013-07-22 2018-01-02 President And Fellows Of Harvard College Microfluidic cartridge assembly
CA2934662C (en) 2013-12-20 2024-02-20 President And Fellows Of Harvard College Low shear microfluidic devices and methods of use and manufacturing thereof
GB2545287A (en) 2013-12-20 2017-06-14 Harvard College Organomimetic devices and methods of use and manufacturing thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6500151B1 (en) * 1999-04-28 2002-12-31 Smiths Group Plc Syringe pump
US20110120871A1 (en) * 2007-12-19 2011-05-26 Stuart William Reid Formation of Layers of Amphiphilic Molecules
WO2009157863A1 (en) * 2008-06-26 2009-12-30 Wigstroem Joakim Microfluidic device
US20110250585A1 (en) * 2008-07-16 2011-10-13 Children's Medical Center Corporation Organ mimic device with microchannels and methods of use and manufacturing thereof

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