AU2014315109B2 - Spirocyclic compounds as tryptophan hydroxylase inhibitors - Google Patents

Spirocyclic compounds as tryptophan hydroxylase inhibitors Download PDF

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Publication number
AU2014315109B2
AU2014315109B2 AU2014315109A AU2014315109A AU2014315109B2 AU 2014315109 B2 AU2014315109 B2 AU 2014315109B2 AU 2014315109 A AU2014315109 A AU 2014315109A AU 2014315109 A AU2014315109 A AU 2014315109A AU 2014315109 B2 AU2014315109 B2 AU 2014315109B2
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Prior art keywords
decane
amino
pyrimidin
diazaspiro
biphenyl
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AU2014315109A
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AU2014315109A1 (en
Inventor
Kenneth Brameld
Stephane De Lombaert
Daniel R. Goldberg
Andrew Scribner
Eric Brian Sjogren
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Altavant Sciences GmbH
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Altavant Sciences GmbH
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Assigned to Roviant Sciences GmbH reassignment Roviant Sciences GmbH Request for Assignment Assignors: KAROS PHARMACEUTICALS, INC.
Assigned to ALTAVANT SCIENCES GMBH reassignment ALTAVANT SCIENCES GMBH Request for Assignment Assignors: Roviant Sciences GmbH
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dispersion Chemistry (AREA)
  • Physiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2014315109A 2013-09-06 2014-09-05 Spirocyclic compounds as tryptophan hydroxylase inhibitors Ceased AU2014315109B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361874545P 2013-09-06 2013-09-06
US61/874,545 2013-09-06
US201361899943P 2013-11-05 2013-11-05
US61/899,943 2013-11-05
US201462004385P 2014-05-29 2014-05-29
US62/004,385 2014-05-29
PCT/US2014/054202 WO2015035113A1 (en) 2013-09-06 2014-09-05 Spirocyclic compounds as tryptophan hydroxylase inhibitors

Publications (2)

Publication Number Publication Date
AU2014315109A1 AU2014315109A1 (en) 2016-03-17
AU2014315109B2 true AU2014315109B2 (en) 2018-08-09

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AU2014315109A Ceased AU2014315109B2 (en) 2013-09-06 2014-09-05 Spirocyclic compounds as tryptophan hydroxylase inhibitors

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US (8) US9199994B2 (OSRAM)
EP (1) EP3041842B8 (OSRAM)
JP (1) JP6470290B2 (OSRAM)
KR (1) KR102336075B1 (OSRAM)
CN (1) CN105764902B (OSRAM)
AR (1) AR097571A1 (OSRAM)
AU (1) AU2014315109B2 (OSRAM)
CA (1) CA2922933C (OSRAM)
CL (1) CL2016000509A1 (OSRAM)
CY (1) CY1122652T1 (OSRAM)
DK (1) DK3041842T3 (OSRAM)
EA (1) EA032304B1 (OSRAM)
EC (1) ECSP16014324A (OSRAM)
ES (1) ES2780828T3 (OSRAM)
HR (1) HRP20200098T1 (OSRAM)
HU (1) HUE047574T2 (OSRAM)
IL (1) IL244315B (OSRAM)
LT (1) LT3041842T (OSRAM)
MX (1) MX371191B (OSRAM)
MY (1) MY186265A (OSRAM)
PE (1) PE20160648A1 (OSRAM)
PH (1) PH12016500416A1 (OSRAM)
PL (1) PL3041842T3 (OSRAM)
PT (1) PT3041842T (OSRAM)
RS (1) RS59871B1 (OSRAM)
SG (2) SG10201802118QA (OSRAM)
SI (1) SI3041842T1 (OSRAM)
TW (1) TWI652267B (OSRAM)
UA (1) UA119247C2 (OSRAM)
WO (1) WO2015035113A1 (OSRAM)

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WO2018060949A1 (en) * 2016-09-30 2018-04-05 Roivant Sciences Gmbh Tryptophan hydroxylase inhibitors for use in the treatment of liver diseases
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CA3119912A1 (en) * 2018-11-14 2020-05-22 Altavant Sciences Gmbh A crystalline spirocyclic compound inhibitor of tryptophan hydroxylase 1 (tph1) for treating diseases or disorders associated with peripheral serotonin
JP2022507533A (ja) * 2018-11-16 2022-01-18 アルタバント・サイエンシズ・ゲーエムベーハー 肺動脈性高血圧症および他疾患に関連する肺動脈性肺高血圧症の治療法
US20200188398A1 (en) 2018-12-17 2020-06-18 Altavant Sciences Gmbh Method for treating sarcoidosis-associated pulmonary hypertension
WO2020128614A1 (en) 2018-12-17 2020-06-25 Altavant Sciences Gmbh Method for treating interstital lung disease
AU2020213746A1 (en) 2019-01-30 2021-08-19 Altavant Sciences Gmbh A dosage regime and method for treating pulmonary arterial hypertension with rodatristat ethyl
US11576915B2 (en) 2019-03-15 2023-02-14 Altavant Sciences Gmbh Method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension and daily dosing
CA3159515A1 (en) * 2019-12-02 2021-06-10 Roivant Sciences Gmbh Treatment of lower airways disorders
CN111007170B (zh) * 2019-12-13 2021-06-29 中国农业科学院农产品加工研究所 骨肽干预治疗骨质疏松中的生物标志物、筛选方法及用途
CN115379825A (zh) * 2020-01-31 2022-11-22 阿尔塔万特科学公司 用rodatristat治疗肺动脉高压的剂量和方法
WO2023062595A1 (en) 2021-10-14 2023-04-20 Altavant Sciences Gmbh Treatment of subjects having pulmonary arterial hypertension with rodatristat ethyl
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KR20250139396A (ko) * 2023-02-09 2025-09-23 제론 코포레이션 텔로머라제 억제제 화합물
WO2025008449A1 (en) 2023-07-05 2025-01-09 Institut National de la Santé et de la Recherche Médicale Use of tryptophan hydroxylase 1 (tph1) inhibitors for the treatment of atherosclerosis

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