AU2014295747B2 - Pharmaceutical, water-soluble and antifungal macromolecular compound - Google Patents

Pharmaceutical, water-soluble and antifungal macromolecular compound Download PDF

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Publication number
AU2014295747B2
AU2014295747B2 AU2014295747A AU2014295747A AU2014295747B2 AU 2014295747 B2 AU2014295747 B2 AU 2014295747B2 AU 2014295747 A AU2014295747 A AU 2014295747A AU 2014295747 A AU2014295747 A AU 2014295747A AU 2014295747 B2 AU2014295747 B2 AU 2014295747B2
Authority
AU
Australia
Prior art keywords
polyconjugate
poly
amino acid
amphotericin
macro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2014295747A
Other languages
English (en)
Other versions
AU2014295747A1 (en
Inventor
Liuyi WAN
Haojun WANG
Guanghui WEN
Jingwen Yang
Dongfang Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BEIJING LABWORLD BIO-MEDICINE TECHNOLOGY CORP Ltd
Original Assignee
Beijing Labworld Bio Medicine Tech Corp Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Labworld Bio Medicine Tech Corp Ltd filed Critical Beijing Labworld Bio Medicine Tech Corp Ltd
Publication of AU2014295747A1 publication Critical patent/AU2014295747A1/en
Application granted granted Critical
Publication of AU2014295747B2 publication Critical patent/AU2014295747B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2014295747A 2013-07-25 2014-02-08 Pharmaceutical, water-soluble and antifungal macromolecular compound Ceased AU2014295747B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201310315504 2013-07-25
CN201310315504.8 2013-07-25
PCT/CN2014/000146 WO2015010439A1 (zh) 2013-07-25 2014-02-08 药用水溶性抗真菌大分子化合物

Publications (2)

Publication Number Publication Date
AU2014295747A1 AU2014295747A1 (en) 2016-02-11
AU2014295747B2 true AU2014295747B2 (en) 2016-08-25

Family

ID=51543906

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014295747A Ceased AU2014295747B2 (en) 2013-07-25 2014-02-08 Pharmaceutical, water-soluble and antifungal macromolecular compound

Country Status (10)

Country Link
US (1) US20160158376A1 (enExample)
EP (1) EP3025733A4 (enExample)
JP (1) JP2016525129A (enExample)
KR (1) KR101749004B1 (enExample)
CN (1) CN104055787B (enExample)
AU (1) AU2014295747B2 (enExample)
CA (1) CA2919145A1 (enExample)
HK (1) HK1220629A1 (enExample)
RU (1) RU2016103088A (enExample)
WO (1) WO2015010439A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110669087B (zh) * 2018-07-02 2023-03-31 上海医药工业研究院 两性霉素b肽衍生物及其制备方法
CN110577921B (zh) * 2019-05-28 2021-04-02 浙江工业大学 产两性霉素b的重组结节链霉菌及其应用
CN110343650B (zh) * 2019-05-28 2020-12-29 浙江工业大学 一种产两性霉素b的重组结节链霉菌及其应用
CN112094362B (zh) * 2020-09-29 2022-04-12 四川大学华西医院 烟酰胺核糖或单核苷酸类似物-大分子载体轭合物及制法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1596129A (zh) * 2001-06-21 2005-03-16 费森尤斯卡比德国有限公司 多糖结合物形式的含有氨基糖的水溶性抗生素
CN101333044A (zh) * 2008-05-20 2008-12-31 北京能拓高科技有限公司 箱式组合式污水处理系统
CN101935336A (zh) * 2010-09-01 2011-01-05 北京大学 一类水溶性紫杉烷类药物的制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1359473A (en) 1970-11-03 1974-07-10 Prodotti Antibiotici Spa Polyenic antibiotic
AU5858690A (en) * 1989-06-14 1991-01-08 Cetus Corporation Polymer/antibiotic conjugate
US5610264A (en) 1995-11-16 1997-03-11 Calwood Chemical Industries, Inc. Continuous process for polyaspartic acid synthesis
DE10155098A1 (de) * 2001-11-09 2003-05-22 Supramol Parenteral Colloids Mittel zur Prävention von mykotischen Kontaminationen bei der Zell- und Gewebekultur bakteriellen, pflanzlichen, animalischen und humanen Ursprungs, bestehend aus Polyen-Makrolid-Konjugaten mit Polysacchariden
US7261875B2 (en) * 2001-12-21 2007-08-28 Board Of Regents, The University Of Texas System Dendritic poly (amino acid) carriers and methods of use
EP1926498A2 (en) * 2005-09-22 2008-06-04 Hadasit Medical Research Services And Development Company Ltd. Dextran and arabinogalactan conjugates of therapeutically active compounds
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
EP2277547A1 (de) * 2009-07-20 2011-01-26 Merck Patent GmbH Epsilon-Polylysin-Konjugate und deren Verwendung
WO2012029827A1 (ja) * 2010-09-02 2012-03-08 日本化薬株式会社 薬物－ブロックコポリマー複合体とそれを含有する医薬の製造方法
US8785569B2 (en) * 2011-11-22 2014-07-22 Original Biomedicals Co., Ltd. Drug carrier with chelating complex micelles and the application thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1596129A (zh) * 2001-06-21 2005-03-16 费森尤斯卡比德国有限公司 多糖结合物形式的含有氨基糖的水溶性抗生素
CN101333044A (zh) * 2008-05-20 2008-12-31 北京能拓高科技有限公司 箱式组合式污水处理系统
CN101935336A (zh) * 2010-09-01 2011-01-05 北京大学 一类水溶性紫杉烷类药物的制备方法和应用

Also Published As

Publication number Publication date
AU2014295747A1 (en) 2016-02-11
WO2015010439A1 (zh) 2015-01-29
US20160158376A1 (en) 2016-06-09
KR20160022915A (ko) 2016-03-02
JP2016525129A (ja) 2016-08-22
CA2919145A1 (en) 2015-01-29
EP3025733A1 (en) 2016-06-01
KR101749004B1 (ko) 2017-06-19
RU2016103088A (ru) 2017-08-30
CN104055787A (zh) 2014-09-24
CN104055787B (zh) 2017-04-26
HK1220629A1 (en) 2017-05-12
EP3025733A4 (en) 2017-09-20

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