CN104055787B - 药用水溶性抗真菌大分子化合物 - Google Patents
药用水溶性抗真菌大分子化合物 Download PDFInfo
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- CN104055787B CN104055787B CN201310688394.XA CN201310688394A CN104055787B CN 104055787 B CN104055787 B CN 104055787B CN 201310688394 A CN201310688394 A CN 201310688394A CN 104055787 B CN104055787 B CN 104055787B
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- Prior art keywords
- amphotericin
- active drug
- conjugate
- multimeric
- acid
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- 238000010189 synthetic method Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000816 toxic dose Toxicity 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 231100000402 unacceptable toxicity Toxicity 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310688394.XA CN104055787B (zh) | 2013-07-25 | 2013-12-16 | 药用水溶性抗真菌大分子化合物 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103155048 | 2013-07-25 | ||
| CN201310315504 | 2013-07-25 | ||
| CN201310315504.8 | 2013-07-25 | ||
| CN201310688394.XA CN104055787B (zh) | 2013-07-25 | 2013-12-16 | 药用水溶性抗真菌大分子化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104055787A CN104055787A (zh) | 2014-09-24 |
| CN104055787B true CN104055787B (zh) | 2017-04-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310688394.XA Expired - Fee Related CN104055787B (zh) | 2013-07-25 | 2013-12-16 | 药用水溶性抗真菌大分子化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20160158376A1 (enExample) |
| EP (1) | EP3025733A4 (enExample) |
| JP (1) | JP2016525129A (enExample) |
| KR (1) | KR101749004B1 (enExample) |
| CN (1) | CN104055787B (enExample) |
| AU (1) | AU2014295747B2 (enExample) |
| CA (1) | CA2919145A1 (enExample) |
| HK (1) | HK1220629A1 (enExample) |
| RU (1) | RU2016103088A (enExample) |
| WO (1) | WO2015010439A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110669087B (zh) * | 2018-07-02 | 2023-03-31 | 上海医药工业研究院 | 两性霉素b肽衍生物及其制备方法 |
| CN110343650B (zh) * | 2019-05-28 | 2020-12-29 | 浙江工业大学 | 一种产两性霉素b的重组结节链霉菌及其应用 |
| CN110577921B (zh) * | 2019-05-28 | 2021-04-02 | 浙江工业大学 | 产两性霉素b的重组结节链霉菌及其应用 |
| CN112094362B (zh) * | 2020-09-29 | 2022-04-12 | 四川大学华西医院 | 烟酰胺核糖或单核苷酸类似物-大分子载体轭合物及制法和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1359473A (en) | 1970-11-03 | 1974-07-10 | Prodotti Antibiotici Spa | Polyenic antibiotic |
| AU5858690A (en) * | 1989-06-14 | 1991-01-08 | Cetus Corporation | Polymer/antibiotic conjugate |
| US5610264A (en) | 1995-11-16 | 1997-03-11 | Calwood Chemical Industries, Inc. | Continuous process for polyaspartic acid synthesis |
| DE10129369C1 (de) * | 2001-06-21 | 2003-03-06 | Fresenius Kabi De Gmbh | Wasserlösliches, einen Aminozucker aufweisendes Antibiotikum in Form eines Pol ysaccharid-Konjugats |
| DE10155098A1 (de) * | 2001-11-09 | 2003-05-22 | Supramol Parenteral Colloids | Mittel zur Prävention von mykotischen Kontaminationen bei der Zell- und Gewebekultur bakteriellen, pflanzlichen, animalischen und humanen Ursprungs, bestehend aus Polyen-Makrolid-Konjugaten mit Polysacchariden |
| US7261875B2 (en) * | 2001-12-21 | 2007-08-28 | Board Of Regents, The University Of Texas System | Dendritic poly (amino acid) carriers and methods of use |
| CA2625426A1 (en) * | 2005-09-22 | 2007-03-29 | Hadasit Medical Research Services & Development Limited | Dextran and arabinogalactan conjugates of therapeutically active compounds |
| US20080181852A1 (en) * | 2007-01-29 | 2008-07-31 | Nitto Denko Corporation | Multi-functional Drug Carriers |
| CN101333044A (zh) * | 2008-05-20 | 2008-12-31 | 北京能拓高科技有限公司 | 箱式组合式污水处理系统 |
| EP2277547A1 (de) * | 2009-07-20 | 2011-01-26 | Merck Patent GmbH | Epsilon-Polylysin-Konjugate und deren Verwendung |
| CN101935336B (zh) * | 2010-09-01 | 2014-04-09 | 北京大学 | 一类水溶性紫杉烷类药物的制备方法和应用 |
| CA2809934C (en) * | 2010-09-02 | 2018-09-04 | Nippon Kayaku Kabushiki Kaisha | Process for producing drug-block copolymer composite and pharmaceutical preparation containing same |
| US8785569B2 (en) * | 2011-11-22 | 2014-07-22 | Original Biomedicals Co., Ltd. | Drug carrier with chelating complex micelles and the application thereof |
-
2013
- 2013-12-16 CN CN201310688394.XA patent/CN104055787B/zh not_active Expired - Fee Related
-
2014
- 2014-02-08 KR KR1020167001958A patent/KR101749004B1/ko not_active Expired - Fee Related
- 2014-02-08 RU RU2016103088A patent/RU2016103088A/ru unknown
- 2014-02-08 JP JP2016528298A patent/JP2016525129A/ja active Pending
- 2014-02-08 WO PCT/CN2014/000146 patent/WO2015010439A1/zh not_active Ceased
- 2014-02-08 EP EP14829240.2A patent/EP3025733A4/en not_active Withdrawn
- 2014-02-08 CA CA2919145A patent/CA2919145A1/en not_active Abandoned
- 2014-02-08 US US14/907,555 patent/US20160158376A1/en not_active Abandoned
- 2014-02-08 HK HK16108769.4A patent/HK1220629A1/en unknown
- 2014-02-08 AU AU2014295747A patent/AU2014295747B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| KR101749004B1 (ko) | 2017-06-19 |
| CN104055787A (zh) | 2014-09-24 |
| JP2016525129A (ja) | 2016-08-22 |
| RU2016103088A (ru) | 2017-08-30 |
| CA2919145A1 (en) | 2015-01-29 |
| US20160158376A1 (en) | 2016-06-09 |
| EP3025733A4 (en) | 2017-09-20 |
| EP3025733A1 (en) | 2016-06-01 |
| AU2014295747A1 (en) | 2016-02-11 |
| HK1220629A1 (en) | 2017-05-12 |
| AU2014295747B2 (en) | 2016-08-25 |
| WO2015010439A1 (zh) | 2015-01-29 |
| KR20160022915A (ko) | 2016-03-02 |
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