HK1220629A1 - Pharmaceutical, water-soluble and antifungal macromolecular compound - Google Patents

Pharmaceutical, water-soluble and antifungal macromolecular compound Download PDF

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Publication number
HK1220629A1
HK1220629A1 HK16108769.4A HK16108769A HK1220629A1 HK 1220629 A1 HK1220629 A1 HK 1220629A1 HK 16108769 A HK16108769 A HK 16108769A HK 1220629 A1 HK1220629 A1 HK 1220629A1
Authority
HK
Hong Kong
Prior art keywords
polyconjugate
poly
amino acid
amphotericin
active drug
Prior art date
Application number
HK16108769.4A
Other languages
English (en)
Chinese (zh)
Inventor
溫光輝
温光辉
宛六
宛六一
于東防
于东防
楊敬文
杨敬文
王浩軍
王浩军
Original Assignee
北京蓝贝望生物医药科技股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 北京蓝贝望生物医药科技股份有限公司 filed Critical 北京蓝贝望生物医药科技股份有限公司
Publication of HK1220629A1 publication Critical patent/HK1220629A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
HK16108769.4A 2013-07-25 2014-02-08 Pharmaceutical, water-soluble and antifungal macromolecular compound HK1220629A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201310315504 2013-07-25
CN201310315504.8 2013-07-25
PCT/CN2014/000146 WO2015010439A1 (zh) 2013-07-25 2014-02-08 药用水溶性抗真菌大分子化合物

Publications (1)

Publication Number Publication Date
HK1220629A1 true HK1220629A1 (en) 2017-05-12

Family

ID=51543906

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16108769.4A HK1220629A1 (en) 2013-07-25 2014-02-08 Pharmaceutical, water-soluble and antifungal macromolecular compound

Country Status (10)

Country Link
US (1) US20160158376A1 (enExample)
EP (1) EP3025733A4 (enExample)
JP (1) JP2016525129A (enExample)
KR (1) KR101749004B1 (enExample)
CN (1) CN104055787B (enExample)
AU (1) AU2014295747B2 (enExample)
CA (1) CA2919145A1 (enExample)
HK (1) HK1220629A1 (enExample)
RU (1) RU2016103088A (enExample)
WO (1) WO2015010439A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110669087B (zh) * 2018-07-02 2023-03-31 上海医药工业研究院 两性霉素b肽衍生物及其制备方法
CN110343650B (zh) * 2019-05-28 2020-12-29 浙江工业大学 一种产两性霉素b的重组结节链霉菌及其应用
CN110577921B (zh) * 2019-05-28 2021-04-02 浙江工业大学 产两性霉素b的重组结节链霉菌及其应用
CN112094362B (zh) * 2020-09-29 2022-04-12 四川大学华西医院 烟酰胺核糖或单核苷酸类似物-大分子载体轭合物及制法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1359473A (en) 1970-11-03 1974-07-10 Prodotti Antibiotici Spa Polyenic antibiotic
AU5858690A (en) * 1989-06-14 1991-01-08 Cetus Corporation Polymer/antibiotic conjugate
US5610264A (en) 1995-11-16 1997-03-11 Calwood Chemical Industries, Inc. Continuous process for polyaspartic acid synthesis
DE10129369C1 (de) * 2001-06-21 2003-03-06 Fresenius Kabi De Gmbh Wasserlösliches, einen Aminozucker aufweisendes Antibiotikum in Form eines Pol ysaccharid-Konjugats
DE10155098A1 (de) * 2001-11-09 2003-05-22 Supramol Parenteral Colloids Mittel zur Prävention von mykotischen Kontaminationen bei der Zell- und Gewebekultur bakteriellen, pflanzlichen, animalischen und humanen Ursprungs, bestehend aus Polyen-Makrolid-Konjugaten mit Polysacchariden
US7261875B2 (en) * 2001-12-21 2007-08-28 Board Of Regents, The University Of Texas System Dendritic poly (amino acid) carriers and methods of use
CA2625426A1 (en) * 2005-09-22 2007-03-29 Hadasit Medical Research Services & Development Limited Dextran and arabinogalactan conjugates of therapeutically active compounds
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
CN101333044A (zh) * 2008-05-20 2008-12-31 北京能拓高科技有限公司 箱式组合式污水处理系统
EP2277547A1 (de) * 2009-07-20 2011-01-26 Merck Patent GmbH Epsilon-Polylysin-Konjugate und deren Verwendung
CN101935336B (zh) * 2010-09-01 2014-04-09 北京大学 一类水溶性紫杉烷类药物的制备方法和应用
CA2809934C (en) * 2010-09-02 2018-09-04 Nippon Kayaku Kabushiki Kaisha Process for producing drug-block copolymer composite and pharmaceutical preparation containing same
US8785569B2 (en) * 2011-11-22 2014-07-22 Original Biomedicals Co., Ltd. Drug carrier with chelating complex micelles and the application thereof

Also Published As

Publication number Publication date
KR101749004B1 (ko) 2017-06-19
CN104055787A (zh) 2014-09-24
CN104055787B (zh) 2017-04-26
JP2016525129A (ja) 2016-08-22
RU2016103088A (ru) 2017-08-30
CA2919145A1 (en) 2015-01-29
US20160158376A1 (en) 2016-06-09
EP3025733A4 (en) 2017-09-20
EP3025733A1 (en) 2016-06-01
AU2014295747A1 (en) 2016-02-11
AU2014295747B2 (en) 2016-08-25
WO2015010439A1 (zh) 2015-01-29
KR20160022915A (ko) 2016-03-02

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