AU2014286995B2 - Polycyclic-carbamoylpyridone compounds and their use for the treatment of HIV infections - Google Patents
Polycyclic-carbamoylpyridone compounds and their use for the treatment of HIV infections Download PDFInfo
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- AU2014286995B2 AU2014286995B2 AU2014286995A AU2014286995A AU2014286995B2 AU 2014286995 B2 AU2014286995 B2 AU 2014286995B2 AU 2014286995 A AU2014286995 A AU 2014286995A AU 2014286995 A AU2014286995 A AU 2014286995A AU 2014286995 B2 AU2014286995 B2 AU 2014286995B2
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- hydrogen
- concentrated
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- 0 *C(*)(*)NC(C(C1=O)=CN(CC2(*C3)IC3CN2C2=O)C2=C1O)=O Chemical compound *C(*)(*)NC(C(C1=O)=CN(CC2(*C3)IC3CN2C2=O)C2=C1O)=O 0.000 description 8
- HFMMTTCKCHKWAS-OSPHWJPCSA-N CCOC(C(C1=O)=CN(C[C@@](C2)(CCC[C@H]2C2)N2C2=O)C2=C1OCc1ccccc1)=O Chemical compound CCOC(C(C1=O)=CN(C[C@@](C2)(CCC[C@H]2C2)N2C2=O)C2=C1OCc1ccccc1)=O HFMMTTCKCHKWAS-OSPHWJPCSA-N 0.000 description 2
- QGCVRZHDWDRLPI-CMVXHFHISA-N C=C/C(/CNC(C(C1=O)=CN(C[C@@](C2)(CCC[C@H]2C2)N2C2=O)C2=C1O)=O)=C/F Chemical compound C=C/C(/CNC(C(C1=O)=CN(C[C@@](C2)(CCC[C@H]2C2)N2C2=O)C2=C1O)=O)=C/F QGCVRZHDWDRLPI-CMVXHFHISA-N 0.000 description 1
- MMDXARSCRJYPDY-UHFFFAOYSA-N CC1=C(C(NC(C2)=C)=C)N2C=C(C(N)=C)C1=O Chemical compound CC1=C(C(NC(C2)=C)=C)N2C=C(C(N)=C)C1=O MMDXARSCRJYPDY-UHFFFAOYSA-N 0.000 description 1
- HXPAFCPLUPJFQF-XYNXFOTISA-N CC1C(CC(CC[C@]2(C3)CN(C=C4C(NCc(c(F)cc(F)c5)c5F)=O)C5=C(C)C4=O)[C@H]3CN2C5=C)C1 Chemical compound CC1C(CC(CC[C@]2(C3)CN(C=C4C(NCc(c(F)cc(F)c5)c5F)=O)C5=C(C)C4=O)[C@H]3CN2C5=C)C1 HXPAFCPLUPJFQF-XYNXFOTISA-N 0.000 description 1
- LRXBHPOPQODAGZ-PTVXEPTESA-N Cc1cc(F)cc(F)c1CNC(C(C1O)=CN(C[C@](C2)(CCC[C@@H]2C2)N2C2=O)C2=C1O)=C Chemical compound Cc1cc(F)cc(F)c1CNC(C(C1O)=CN(C[C@](C2)(CCC[C@@H]2C2)N2C2=O)C2=C1O)=C LRXBHPOPQODAGZ-PTVXEPTESA-N 0.000 description 1
- OBYYGQMAUDYBAV-UHFFFAOYSA-N Cc1ccc(CNC(C(C2=O)=CN(CC(C(C3)CC3C3)N3C3=O)C3=C2O)=O)c(F)c1 Chemical compound Cc1ccc(CNC(C(C2=O)=CN(CC(C(C3)CC3C3)N3C3=O)C3=C2O)=O)c(F)c1 OBYYGQMAUDYBAV-UHFFFAOYSA-N 0.000 description 1
- VLMDAUAZUOVFKU-QRQCRPRQSA-N NC(C(C1=O)=CN(C[C@@](C2)(CCC[C@H]2C2)N2C2=O)C2=C1OCc1ccccc1)=O Chemical compound NC(C(C1=O)=CN(C[C@@](C2)(CCC[C@H]2C2)N2C2=O)C2=C1OCc1ccccc1)=O VLMDAUAZUOVFKU-QRQCRPRQSA-N 0.000 description 1
- VBTQFGJFGWVPLY-RBSBEOHCSA-N O=C(C(C1=O)=CN(C[C@](C2)(CCC[C@@H]2C2)N2C2=O)C2=C1OCc1ccccc1)NCc(c(F)cc(F)c1)c1F Chemical compound O=C(C(C1=O)=CN(C[C@](C2)(CCC[C@@H]2C2)N2C2=O)C2=C1OCc1ccccc1)NCc(c(F)cc(F)c1)c1F VBTQFGJFGWVPLY-RBSBEOHCSA-N 0.000 description 1
- UGKYRBKXBKAWIZ-UULLZXFKSA-N O=C(C(C1=O)=CN(C[C@](CC2)(C[C@@H]2C2)N2C2=O)C2=C1OCc1ccccc1)NCc(c(F)cc(F)c1)c1F Chemical compound O=C(C(C1=O)=CN(C[C@](CC2)(C[C@@H]2C2)N2C2=O)C2=C1OCc1ccccc1)NCc(c(F)cc(F)c1)c1F UGKYRBKXBKAWIZ-UULLZXFKSA-N 0.000 description 1
- ZNYMMMAYIVJGJI-OYHNWAKOSA-N OC(C(C1=O)=CN(C[C@](C2)(CCC[C@@H]2C2)N2C2=O)C2=C1OCc1ccccc1)=O Chemical compound OC(C(C1=O)=CN(C[C@](C2)(CCC[C@@H]2C2)N2C2=O)C2=C1OCc1ccccc1)=O ZNYMMMAYIVJGJI-OYHNWAKOSA-N 0.000 description 1
- QERPVLPCCZNVKX-SZNDQCEHSA-N OC(C(C1=O)=CN(C[C@](CC2)(C[C@@H]2C2)N2C2=O)C2=C1OCc1ccccc1)=O Chemical compound OC(C(C1=O)=CN(C[C@](CC2)(C[C@@H]2C2)N2C2=O)C2=C1OCc1ccccc1)=O QERPVLPCCZNVKX-SZNDQCEHSA-N 0.000 description 1
- SBWPHTTXWNSHCB-UZJPJQLHSA-N OC1=C(C(N(C[C@H](CC2)C3)[C@@]23C2)=O)N2C=C(C(NCc(c(F)cc(F)c2)c2F)=O)C1=O Chemical compound OC1=C(C(N(C[C@H](CC2)C3)[C@@]23C2)=O)N2C=C(C(NCc(c(F)cc(F)c2)c2F)=O)C1=O SBWPHTTXWNSHCB-UZJPJQLHSA-N 0.000 description 1
- KHPMSEOFOMMZME-LMRGUYSOSA-N OC1=C(C(N(C[C@H](CC2)CC3)[C@@]23C2)=O)N2C=C(C(NCc(c(F)c2)ccc2F)=O)C1=O Chemical compound OC1=C(C(N(C[C@H](CC2)CC3)[C@@]23C2)=O)N2C=C(C(NCc(c(F)c2)ccc2F)=O)C1=O KHPMSEOFOMMZME-LMRGUYSOSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2018236701A AU2018236701B2 (en) | 2013-07-12 | 2018-09-24 | Polycyclic-carbamoylpyridone compounds and their use for the treatment of HIV infections |
| AU2020202368A AU2020202368A1 (en) | 2013-07-12 | 2020-04-03 | Polycyclic-carbamoylpyridone compounds and their use for the treatment of HIV infections |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361845807P | 2013-07-12 | 2013-07-12 | |
| US61/845,807 | 2013-07-12 | ||
| PCT/US2014/046415 WO2015006733A1 (en) | 2013-07-12 | 2014-07-11 | Polycyclic-carbamoylpyridone compounds and their use for the treatment of hiv infections |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2018236701A Division AU2018236701B2 (en) | 2013-07-12 | 2018-09-24 | Polycyclic-carbamoylpyridone compounds and their use for the treatment of HIV infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2014286995A1 AU2014286995A1 (en) | 2016-03-03 |
| AU2014286995B2 true AU2014286995B2 (en) | 2018-10-18 |
Family
ID=51257630
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014286995A Active AU2014286995B2 (en) | 2013-07-12 | 2014-07-11 | Polycyclic-carbamoylpyridone compounds and their use for the treatment of HIV infections |
| AU2018236701A Active AU2018236701B2 (en) | 2013-07-12 | 2018-09-24 | Polycyclic-carbamoylpyridone compounds and their use for the treatment of HIV infections |
| AU2020202368A Abandoned AU2020202368A1 (en) | 2013-07-12 | 2020-04-03 | Polycyclic-carbamoylpyridone compounds and their use for the treatment of HIV infections |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2018236701A Active AU2018236701B2 (en) | 2013-07-12 | 2018-09-24 | Polycyclic-carbamoylpyridone compounds and their use for the treatment of HIV infections |
| AU2020202368A Abandoned AU2020202368A1 (en) | 2013-07-12 | 2020-04-03 | Polycyclic-carbamoylpyridone compounds and their use for the treatment of HIV infections |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US9458159B2 (show.php) |
| EP (2) | EP3252053B1 (show.php) |
| JP (1) | JP6411492B2 (show.php) |
| AU (3) | AU2014286995B2 (show.php) |
| CA (1) | CA2918055C (show.php) |
| CY (1) | CY1119545T1 (show.php) |
| DK (1) | DK3019499T3 (show.php) |
| ES (2) | ES2856867T3 (show.php) |
| HR (1) | HRP20171807T1 (show.php) |
| HU (1) | HUE037343T2 (show.php) |
| LT (1) | LT3019499T (show.php) |
| NO (1) | NO2865735T3 (show.php) |
| PL (1) | PL3019499T3 (show.php) |
| PT (1) | PT3019499T (show.php) |
| RS (1) | RS56539B1 (show.php) |
| SI (2) | SI3019499T1 (show.php) |
| SM (1) | SMT201700525T1 (show.php) |
| WO (1) | WO2015006733A1 (show.php) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3067358T3 (da) | 2012-12-21 | 2019-11-04 | Gilead Sciences Inc | Polycykliske carbamoylpyridon-forbindelser og deres farmaceutiske anvendelse |
| NO2865735T3 (show.php) * | 2013-07-12 | 2018-07-21 | ||
| PL3019503T3 (pl) * | 2013-07-12 | 2018-01-31 | Gilead Sciences Inc | Policykliczne związki karbamoilopirydonowe i ich zastosowanie do leczenia infekcji hiv |
| WO2016027879A1 (ja) | 2014-08-22 | 2016-02-25 | 塩野義製薬株式会社 | インテグラーゼ阻害活性を有する多環性ピリドン誘導体 |
| AU2016216673B2 (en) | 2015-03-04 | 2017-02-02 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| EP3277691B1 (en) * | 2015-04-02 | 2019-01-30 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| US20210292327A1 (en) | 2015-08-26 | 2021-09-23 | Gilead Sciences, Inc. | Deuterated toll-like receptor modulators |
| WO2017048727A1 (en) | 2015-09-15 | 2017-03-23 | Gilead Sciences, Inc. | Modulators of toll-like recptors for the treatment of hiv |
| BR102016026127A2 (pt) | 2015-11-09 | 2017-05-16 | Gilead Sciences Inc | composições terapêuticas para o tratamento do vírus da imunodeficiência humana |
| AU2017318601B2 (en) | 2016-09-02 | 2020-09-03 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| US10640499B2 (en) | 2016-09-02 | 2020-05-05 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| JOP20190130A1 (ar) | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
| CN110526930B (zh) * | 2018-05-23 | 2022-06-03 | 莫云芬 | 抗hiv病毒的含硫多环-羟基吡啶酮甲酰胺类似物及其应用 |
| EP4257137A3 (en) | 2018-05-31 | 2023-11-01 | Shionogi & Co., Ltd | Polycyclic carbamoylpyridone derivatives for the treatment of hiv |
| SG11202011386QA (en) | 2018-05-31 | 2020-12-30 | Shionogi & Co | Polycyclic pyridone derivative |
| WO2020197991A1 (en) | 2019-03-22 | 2020-10-01 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use |
| CA3140708A1 (en) | 2019-06-18 | 2020-12-24 | Helen Horton | Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives |
| US20200398978A1 (en) | 2019-06-20 | 2020-12-24 | Bell Helicopter Textron Inc. | Low-drag rotor blade extension |
| EP4066839A4 (en) | 2019-11-28 | 2023-12-27 | Shionogi & Co., Ltd | PROPHYLACTIC AND THERAPEUTIC MEDICINAL PRODUCT FOR HIV INFECTIOUS DISEASES, CHARACTERIZED BY CONTAINING THE COMBINATION OF INTEGRAS INHIBITORS AND ANTI-HIV AGENTS |
| IL295677A (en) | 2020-02-24 | 2022-10-01 | Gilead Sciences Inc | Tetracyclic compounds for treating hiv infection |
| US12421235B2 (en) * | 2020-09-30 | 2025-09-23 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and uses thereof |
| PT4196479T (pt) | 2021-01-19 | 2024-01-03 | Gilead Sciences Inc | Compostos de piridotriazinas substituídos e suas utilizações |
| TWI856796B (zh) | 2022-04-06 | 2024-09-21 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
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| WO2006116764A1 (en) * | 2005-04-28 | 2006-11-02 | Smithkline Beecham Corporation | Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity |
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