AU2014236812B2 - Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer - Google Patents
Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer Download PDFInfo
- Publication number
- AU2014236812B2 AU2014236812B2 AU2014236812A AU2014236812A AU2014236812B2 AU 2014236812 B2 AU2014236812 B2 AU 2014236812B2 AU 2014236812 A AU2014236812 A AU 2014236812A AU 2014236812 A AU2014236812 A AU 2014236812A AU 2014236812 B2 AU2014236812 B2 AU 2014236812B2
- Authority
- AU
- Australia
- Prior art keywords
- pharmaceutically acceptable
- compound
- methyl
- accordance
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 C[C@@](C**)N(C(C(c1cc(Cl)ccc1)OC1(C)Cc(nc2)ccc2C(OC)=O)c(cc2)ccc2Cl)C1=O Chemical compound C[C@@](C**)N(C(C(c1cc(Cl)ccc1)OC1(C)Cc(nc2)ccc2C(OC)=O)c(cc2)ccc2Cl)C1=O 0.000 description 2
- KENBSHJJBLHWDE-XNGFZORESA-N CC(C)(C)S(CC(C1CC1)N(C(C(c1cccc(Cl)c1)O[C@]1(C)CC(N)=O)c(cc2)cc(F)c2Cl)C1=O)(=O)=O Chemical compound CC(C)(C)S(CC(C1CC1)N(C(C(c1cccc(Cl)c1)O[C@]1(C)CC(N)=O)c(cc2)cc(F)c2Cl)C1=O)(=O)=O KENBSHJJBLHWDE-XNGFZORESA-N 0.000 description 1
- OTQRFDJHHZHHNT-CMYZZGIHSA-N CC(C)(C)S(CC(C1CC1)N(C([C@@H](c1cc(Cl)ccc1)O[C@@]1(C)Cc(nc2)ccc2C(O)=O)c(cc2)ccc2Cl)C1=O)(=O)=O Chemical compound CC(C)(C)S(CC(C1CC1)N(C([C@@H](c1cc(Cl)ccc1)O[C@@]1(C)Cc(nc2)ccc2C(O)=O)c(cc2)ccc2Cl)C1=O)(=O)=O OTQRFDJHHZHHNT-CMYZZGIHSA-N 0.000 description 1
- OTQRFDJHHZHHNT-DYIGVOLASA-N CC(C)(C)S(CC(C1CC1)N(C([C@@H](c1cc(Cl)ccc1)O[C@]1(C)Cc(nc2)ccc2C(O)=O)c(cc2)ccc2Cl)C1=O)(=O)=O Chemical compound CC(C)(C)S(CC(C1CC1)N(C([C@@H](c1cc(Cl)ccc1)O[C@]1(C)Cc(nc2)ccc2C(O)=O)c(cc2)ccc2Cl)C1=O)(=O)=O OTQRFDJHHZHHNT-DYIGVOLASA-N 0.000 description 1
- SXMIZOGICDWOEQ-PVCZSOGJSA-N C[C@@H](CO[Si](C)(C)C(C)(C)C)NC(C(C)(Cc(nc1)ccc1C(OC)=O)OCl)=O Chemical compound C[C@@H](CO[Si](C)(C)C(C)(C)C)NC(C(C)(Cc(nc1)ccc1C(OC)=O)OCl)=O SXMIZOGICDWOEQ-PVCZSOGJSA-N 0.000 description 1
- OSOUNOBYRMOXQQ-UHFFFAOYSA-N Cc1cc(Cl)ccc1 Chemical compound Cc1cc(Cl)ccc1 OSOUNOBYRMOXQQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361784230P | 2013-03-14 | 2013-03-14 | |
| US61/784,230 | 2013-03-14 | ||
| PCT/US2014/026584 WO2014151863A1 (en) | 2013-03-14 | 2014-03-13 | Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2014236812A1 AU2014236812A1 (en) | 2015-09-17 |
| AU2014236812B2 true AU2014236812B2 (en) | 2018-03-01 |
Family
ID=50442720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014236812A Active AU2014236812B2 (en) | 2013-03-14 | 2014-03-13 | Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9758495B2 (https=) |
| EP (1) | EP2970237B1 (https=) |
| JP (1) | JP6377123B2 (https=) |
| AU (1) | AU2014236812B2 (https=) |
| CA (1) | CA2906538C (https=) |
| MX (1) | MX374513B (https=) |
| WO (1) | WO2014151863A1 (https=) |
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| JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
| MX352672B (es) | 2011-09-27 | 2017-12-04 | Amgen Inc | Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. |
| US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
| AU2014236812B2 (en) | 2013-03-14 | 2018-03-01 | Amgen Inc. | Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer |
| CN105358530A (zh) | 2013-06-10 | 2016-02-24 | 美国安进公司 | 制备mdm2抑制剂的方法及其结晶形式 |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| HRP20220718T1 (hr) | 2013-11-11 | 2022-09-30 | Amgen Inc. | Kombinacijska terapija uključujući inhibitor mdm2 i jedan ili više dodatnih farmaceutski aktivnih sredstava za liječenje raka |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| JP6817962B2 (ja) | 2015-01-20 | 2021-01-20 | アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． | ターゲティングされたアンドロゲン受容体分解のための化合物および方法 |
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| US11173211B2 (en) | 2016-12-23 | 2021-11-16 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides |
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| WO2011153509A1 (en) * | 2010-06-04 | 2011-12-08 | Amgen Inc. | Piperidinone derivatives as mdm2 inhibitors for the treatment of cancer |
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| US20160039774A1 (en) | 2016-02-11 |
| JP6377123B2 (ja) | 2018-08-22 |
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| MX2015012427A (es) | 2016-01-12 |
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