AU2014236812B2 - Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer - Google Patents
Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer Download PDFInfo
- Publication number
- AU2014236812B2 AU2014236812B2 AU2014236812A AU2014236812A AU2014236812B2 AU 2014236812 B2 AU2014236812 B2 AU 2014236812B2 AU 2014236812 A AU2014236812 A AU 2014236812A AU 2014236812 A AU2014236812 A AU 2014236812A AU 2014236812 B2 AU2014236812 B2 AU 2014236812B2
- Authority
- AU
- Australia
- Prior art keywords
- pharmaceutically acceptable
- compound
- methyl
- accordance
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 C[C@@](C**)N(C(C(c1cc(Cl)ccc1)OC1(C)Cc(nc2)ccc2C(OC)=O)c(cc2)ccc2Cl)C1=O Chemical compound C[C@@](C**)N(C(C(c1cc(Cl)ccc1)OC1(C)Cc(nc2)ccc2C(OC)=O)c(cc2)ccc2Cl)C1=O 0.000 description 2
- KENBSHJJBLHWDE-XNGFZORESA-N CC(C)(C)S(CC(C1CC1)N(C(C(c1cccc(Cl)c1)O[C@]1(C)CC(N)=O)c(cc2)cc(F)c2Cl)C1=O)(=O)=O Chemical compound CC(C)(C)S(CC(C1CC1)N(C(C(c1cccc(Cl)c1)O[C@]1(C)CC(N)=O)c(cc2)cc(F)c2Cl)C1=O)(=O)=O KENBSHJJBLHWDE-XNGFZORESA-N 0.000 description 1
- OTQRFDJHHZHHNT-CMYZZGIHSA-N CC(C)(C)S(CC(C1CC1)N(C([C@@H](c1cc(Cl)ccc1)O[C@@]1(C)Cc(nc2)ccc2C(O)=O)c(cc2)ccc2Cl)C1=O)(=O)=O Chemical compound CC(C)(C)S(CC(C1CC1)N(C([C@@H](c1cc(Cl)ccc1)O[C@@]1(C)Cc(nc2)ccc2C(O)=O)c(cc2)ccc2Cl)C1=O)(=O)=O OTQRFDJHHZHHNT-CMYZZGIHSA-N 0.000 description 1
- OTQRFDJHHZHHNT-DYIGVOLASA-N CC(C)(C)S(CC(C1CC1)N(C([C@@H](c1cc(Cl)ccc1)O[C@]1(C)Cc(nc2)ccc2C(O)=O)c(cc2)ccc2Cl)C1=O)(=O)=O Chemical compound CC(C)(C)S(CC(C1CC1)N(C([C@@H](c1cc(Cl)ccc1)O[C@]1(C)Cc(nc2)ccc2C(O)=O)c(cc2)ccc2Cl)C1=O)(=O)=O OTQRFDJHHZHHNT-DYIGVOLASA-N 0.000 description 1
- SXMIZOGICDWOEQ-PVCZSOGJSA-N C[C@@H](CO[Si](C)(C)C(C)(C)C)NC(C(C)(Cc(nc1)ccc1C(OC)=O)OCl)=O Chemical compound C[C@@H](CO[Si](C)(C)C(C)(C)C)NC(C(C)(Cc(nc1)ccc1C(OC)=O)OCl)=O SXMIZOGICDWOEQ-PVCZSOGJSA-N 0.000 description 1
- OSOUNOBYRMOXQQ-UHFFFAOYSA-N Cc1cc(Cl)ccc1 Chemical compound Cc1cc(Cl)ccc1 OSOUNOBYRMOXQQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361784230P | 2013-03-14 | 2013-03-14 | |
| US61/784,230 | 2013-03-14 | ||
| PCT/US2014/026584 WO2014151863A1 (en) | 2013-03-14 | 2014-03-13 | Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2014236812A1 AU2014236812A1 (en) | 2015-09-17 |
| AU2014236812B2 true AU2014236812B2 (en) | 2018-03-01 |
Family
ID=50442720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014236812A Active AU2014236812B2 (en) | 2013-03-14 | 2014-03-13 | Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9758495B2 (enExample) |
| EP (1) | EP2970237B1 (enExample) |
| JP (1) | JP6377123B2 (enExample) |
| AU (1) | AU2014236812B2 (enExample) |
| CA (1) | CA2906538C (enExample) |
| MX (1) | MX374513B (enExample) |
| WO (1) | WO2014151863A1 (enExample) |
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| JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
| MX352672B (es) | 2011-09-27 | 2017-12-04 | Amgen Inc | Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. |
| US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
| WO2014151863A1 (en) | 2013-03-14 | 2014-09-25 | Amgen Inc. | Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer |
| JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| SMT202200241T1 (it) | 2013-11-11 | 2022-09-14 | Amgen Inc | Politerapia che include un inibitore di mdm2 e uno o più agenti farmaceuticamente attivi aggiuntivi per il trattamento di cancri |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| CN107428734A (zh) | 2015-01-20 | 2017-12-01 | 阿尔维纳斯股份有限公司 | 用于雄激素受体的靶向降解的化合物和方法 |
| US12312316B2 (en) | 2015-01-20 | 2025-05-27 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| WO2016197114A1 (en) | 2015-06-05 | 2016-12-08 | Arvinas, Inc. | Tank-binding kinase-1 protacs and associated methods of use |
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| IL304982A (en) | 2016-11-01 | 2023-10-01 | Arvinas Operations Inc | PROTACS Targeted Tau-Protein and Related Methods of Use |
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| JP2020505327A (ja) | 2016-12-23 | 2020-02-20 | アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． | Ｅｇｆｒタンパク質分解標的化キメラ分子およびその関連する使用方法 |
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| US11173211B2 (en) | 2016-12-23 | 2021-11-16 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides |
| JP7679173B2 (ja) | 2016-12-23 | 2025-05-19 | アルビナス・オペレーションズ・インコーポレイテッド | Ｒａｆ（急速進行性線維肉腫）ポリペプチドの標的分解のための化合物および方法 |
| US11191741B2 (en) | 2016-12-24 | 2021-12-07 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide |
| KR20230140606A (ko) | 2017-01-26 | 2023-10-06 | 아비나스 오퍼레이션스, 인코포레이티드 | 에스트로겐 수용체 단백질 분해 조절제 및 관련 사용 방법 |
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| JP7297053B2 (ja) | 2018-08-20 | 2023-06-23 | アルビナス・オペレーションズ・インコーポレイテッド | 神経変性疾患を治療するためのｅ３ユビキチンリガーゼ結合活性を有するキメラ（ｐｒｏｔａｃ）化合物を標的とし、アルファ－シヌクレインタンパク質を標的とするタンパク質分解 |
| JP7656589B2 (ja) | 2019-08-26 | 2025-04-03 | アルビナス・オペレーションズ・インコーポレイテッド | エストロゲン受容体分解物質としてのテトラヒドロナフタレン誘導体を用いて乳癌を治療する方法 |
| CN114761387A (zh) | 2019-12-05 | 2022-07-15 | 巴斯夫欧洲公司 | 取代的芳族羧酰胺的制备 |
| CN115315419A (zh) | 2020-04-29 | 2022-11-08 | 巴斯夫欧洲公司 | 通过钯催化的羰基化反应制备芳族羧酰胺 |
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| US9758495B2 (en) | 2017-09-12 |
| WO2014151863A1 (en) | 2014-09-25 |
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| EP2970237B1 (en) | 2017-09-27 |
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| JP2016513660A (ja) | 2016-05-16 |
| EP2970237A1 (en) | 2016-01-20 |
| MX374513B (es) | 2025-03-06 |
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