AU2014236812B2 - Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer - Google Patents
Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer Download PDFInfo
- Publication number
- AU2014236812B2 AU2014236812B2 AU2014236812A AU2014236812A AU2014236812B2 AU 2014236812 B2 AU2014236812 B2 AU 2014236812B2 AU 2014236812 A AU2014236812 A AU 2014236812A AU 2014236812 A AU2014236812 A AU 2014236812A AU 2014236812 B2 AU2014236812 B2 AU 2014236812B2
- Authority
- AU
- Australia
- Prior art keywords
- pharmaceutically acceptable
- compound
- methyl
- accordance
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 0 C[C@@](C**)N(C(C(c1cc(Cl)ccc1)OC1(C)Cc(nc2)ccc2C(OC)=O)c(cc2)ccc2Cl)C1=O Chemical compound C[C@@](C**)N(C(C(c1cc(Cl)ccc1)OC1(C)Cc(nc2)ccc2C(OC)=O)c(cc2)ccc2Cl)C1=O 0.000 description 2
- KENBSHJJBLHWDE-XNGFZORESA-N CC(C)(C)S(CC(C1CC1)N(C(C(c1cccc(Cl)c1)O[C@]1(C)CC(N)=O)c(cc2)cc(F)c2Cl)C1=O)(=O)=O Chemical compound CC(C)(C)S(CC(C1CC1)N(C(C(c1cccc(Cl)c1)O[C@]1(C)CC(N)=O)c(cc2)cc(F)c2Cl)C1=O)(=O)=O KENBSHJJBLHWDE-XNGFZORESA-N 0.000 description 1
- OTQRFDJHHZHHNT-CMYZZGIHSA-N CC(C)(C)S(CC(C1CC1)N(C([C@@H](c1cc(Cl)ccc1)O[C@@]1(C)Cc(nc2)ccc2C(O)=O)c(cc2)ccc2Cl)C1=O)(=O)=O Chemical compound CC(C)(C)S(CC(C1CC1)N(C([C@@H](c1cc(Cl)ccc1)O[C@@]1(C)Cc(nc2)ccc2C(O)=O)c(cc2)ccc2Cl)C1=O)(=O)=O OTQRFDJHHZHHNT-CMYZZGIHSA-N 0.000 description 1
- OTQRFDJHHZHHNT-DYIGVOLASA-N CC(C)(C)S(CC(C1CC1)N(C([C@@H](c1cc(Cl)ccc1)O[C@]1(C)Cc(nc2)ccc2C(O)=O)c(cc2)ccc2Cl)C1=O)(=O)=O Chemical compound CC(C)(C)S(CC(C1CC1)N(C([C@@H](c1cc(Cl)ccc1)O[C@]1(C)Cc(nc2)ccc2C(O)=O)c(cc2)ccc2Cl)C1=O)(=O)=O OTQRFDJHHZHHNT-DYIGVOLASA-N 0.000 description 1
- SXMIZOGICDWOEQ-PVCZSOGJSA-N C[C@@H](CO[Si](C)(C)C(C)(C)C)NC(C(C)(Cc(nc1)ccc1C(OC)=O)OCl)=O Chemical compound C[C@@H](CO[Si](C)(C)C(C)(C)C)NC(C(C)(Cc(nc1)ccc1C(OC)=O)OCl)=O SXMIZOGICDWOEQ-PVCZSOGJSA-N 0.000 description 1
- OSOUNOBYRMOXQQ-UHFFFAOYSA-N Cc1cc(Cl)ccc1 Chemical compound Cc1cc(Cl)ccc1 OSOUNOBYRMOXQQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361784230P | 2013-03-14 | 2013-03-14 | |
| US61/784,230 | 2013-03-14 | ||
| PCT/US2014/026584 WO2014151863A1 (en) | 2013-03-14 | 2014-03-13 | Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2014236812A1 AU2014236812A1 (en) | 2015-09-17 |
| AU2014236812B2 true AU2014236812B2 (en) | 2018-03-01 |
Family
ID=50442720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014236812A Active AU2014236812B2 (en) | 2013-03-14 | 2014-03-13 | Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9758495B2 (enExample) |
| EP (1) | EP2970237B1 (enExample) |
| JP (1) | JP6377123B2 (enExample) |
| AU (1) | AU2014236812B2 (enExample) |
| CA (1) | CA2906538C (enExample) |
| MX (1) | MX374513B (enExample) |
| WO (1) | WO2014151863A1 (enExample) |
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| JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
| WO2013049250A1 (en) | 2011-09-27 | 2013-04-04 | Amgen Inc. | Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer |
| US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
| WO2014151863A1 (en) | 2013-03-14 | 2014-09-25 | Amgen Inc. | Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer |
| JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| PT3068393T (pt) | 2013-11-11 | 2022-06-14 | Amgen Inc | Terapia de combinação, incluindo um inibidor de mdm2 e um ou mais agentes farmaceuticamente ativos adicionais para o tratamento de cancros |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| US12312316B2 (en) | 2015-01-20 | 2025-05-27 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| HK1247204A1 (zh) | 2015-01-20 | 2018-09-21 | Arvinas Operations, Inc. | 用於雄激素受体的靶向降解的化合物和方法 |
| EP3302482A4 (en) | 2015-06-05 | 2018-12-19 | Arvinas, Inc. | Tank-binding kinase-1 protacs and associated methods of use |
| US10772962B2 (en) | 2015-08-19 | 2020-09-15 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of bromodomain-containing proteins |
| CN109152843A (zh) | 2016-05-20 | 2019-01-04 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
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| AU2017382436C1 (en) | 2016-12-23 | 2021-05-27 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of Rapidly Accelerated Fibrosarcoma polypeptides |
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| EP2970237A1 (en) | 2016-01-20 |
| MX374513B (es) | 2025-03-06 |
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| WO2014151863A1 (en) | 2014-09-25 |
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