AU2014209949B2 - 2,3-dihydroimidazol(1,2-c)pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (Lp-PLA2) inhibitors - Google Patents

2,3-dihydroimidazol(1,2-c)pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (Lp-PLA2) inhibitors Download PDF

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Publication number
AU2014209949B2
AU2014209949B2 AU2014209949A AU2014209949A AU2014209949B2 AU 2014209949 B2 AU2014209949 B2 AU 2014209949B2 AU 2014209949 A AU2014209949 A AU 2014209949A AU 2014209949 A AU2014209949 A AU 2014209949A AU 2014209949 B2 AU2014209949 B2 AU 2014209949B2
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AU
Australia
Prior art keywords
pyrimidin
oxy
dihydroimidazo
esi
mmol
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Ceased
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AU2014209949A
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AU2014209949A1 (en
Inventor
Yingxia SANG
Zehong Wan
Qing Zhang
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GlaxoSmithKline Intellectual Property Development Ltd
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GlaxoSmithKline Intellectual Property Development Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2014209949A 2013-01-25 2014-01-23 2,3-dihydroimidazol(1,2-c)pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (Lp-PLA2) inhibitors Ceased AU2014209949B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2013/070976 2013-01-25
CN2013070976 2013-01-25
CN2013001556 2013-12-12
CNPCT/CN2013/001556 2013-12-12
PCT/EP2014/051286 WO2014114694A1 (en) 2013-01-25 2014-01-23 2,3-dihydroimidazol[1,2-c]pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (lp-pla2) inhibitors

Publications (2)

Publication Number Publication Date
AU2014209949A1 AU2014209949A1 (en) 2015-07-30
AU2014209949B2 true AU2014209949B2 (en) 2016-09-08

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ID=50002724

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AU2014209949A Ceased AU2014209949B2 (en) 2013-01-25 2014-01-23 2,3-dihydroimidazol(1,2-c)pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (Lp-PLA2) inhibitors

Country Status (23)

Country Link
US (1) US9708330B2 (cg-RX-API-DMAC7.html)
EP (1) EP2948452B1 (cg-RX-API-DMAC7.html)
JP (1) JP6306053B2 (cg-RX-API-DMAC7.html)
KR (1) KR20150108897A (cg-RX-API-DMAC7.html)
CN (1) CN105008368B (cg-RX-API-DMAC7.html)
AU (1) AU2014209949B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015017759B1 (cg-RX-API-DMAC7.html)
CA (1) CA2899091A1 (cg-RX-API-DMAC7.html)
CL (1) CL2015002060A1 (cg-RX-API-DMAC7.html)
CR (1) CR20150390A (cg-RX-API-DMAC7.html)
EA (1) EA025885B1 (cg-RX-API-DMAC7.html)
ES (1) ES2642762T3 (cg-RX-API-DMAC7.html)
HK (1) HK1216425A1 (cg-RX-API-DMAC7.html)
IL (1) IL240046A0 (cg-RX-API-DMAC7.html)
MA (1) MA38284B1 (cg-RX-API-DMAC7.html)
MX (1) MX2015009633A (cg-RX-API-DMAC7.html)
PE (1) PE20151251A1 (cg-RX-API-DMAC7.html)
PH (1) PH12015501586A1 (cg-RX-API-DMAC7.html)
SG (1) SG11201505520WA (cg-RX-API-DMAC7.html)
TW (1) TW201443054A (cg-RX-API-DMAC7.html)
UY (1) UY35276A (cg-RX-API-DMAC7.html)
WO (1) WO2014114694A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201505025B (cg-RX-API-DMAC7.html)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014209949B2 (en) 2013-01-25 2016-09-08 Glaxosmithkline Intellectual Property Development Limited 2,3-dihydroimidazol(1,2-c)pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (Lp-PLA2) inhibitors
WO2016012917A1 (en) * 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
CN106536525B (zh) * 2014-07-22 2019-05-03 葛兰素史密斯克莱知识产权发展有限公司 化合物
WO2016012916A1 (en) * 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
CN104892459A (zh) * 2015-06-16 2015-09-09 苏州明锐医药科技有限公司 利奥西呱中间体及其制备方法
CN112574221B (zh) * 2019-09-30 2022-03-04 上海纽思克生物科技有限公司 四环嘧啶酮类化合物、其制备方法、其组合物和用途
IL292668A (en) * 2019-11-09 2022-07-01 Shanghai Simr Biotechnology Co Ltd A tricyclic derivative of dihydroimidazopyrimidone, its preparation method, pharmaceutical preparation and its use
CN111533699B (zh) * 2020-05-27 2023-12-01 龙曦宁（上海）医药科技有限公司 一种2-（三氟甲基）嘧啶-5-醇的合成方法
CN113861220B (zh) * 2020-06-30 2023-06-16 上海纽思克生物科技有限公司 三环嘧啶酮类化合物、其制备方法、其组合物和用途
CN113912622B (zh) * 2020-07-10 2023-12-01 上海纽思克生物科技有限公司 三环嘧啶酮类化合物、其制备方法、其组合物和用途
CN115304620A (zh) 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途
CN114057740B (zh) * 2021-12-15 2024-04-02 上海赛默罗生物科技有限公司 螺环嘧啶酮衍生物、其制备方法、药物组合物和用途
KR20250055539A (ko) * 2022-08-04 2025-04-24 4비 테크놀로지스 (베이징) 컴퍼니 리미티드 Lp-pla2 억제제로서의 디하이드로이미다조-피리미디논 화합물 및 이의 용도
CN116925023B (zh) * 2023-07-18 2025-11-21 江苏桐孚高新材料有限公司 2-全氟烷基-4h-吡喃-4-酮衍生物的改进合成方法

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Also Published As

Publication number Publication date
BR112015017759B1 (pt) 2022-05-24
CL2015002060A1 (es) 2015-11-27
ZA201505025B (en) 2017-08-30
PE20151251A1 (es) 2015-09-10
MA38284A1 (fr) 2017-12-29
JP2016505058A (ja) 2016-02-18
CA2899091A1 (en) 2014-07-31
IL240046A0 (en) 2015-08-31
US9708330B2 (en) 2017-07-18
UY35276A (es) 2014-08-29
EP2948452B1 (en) 2017-08-09
TW201443054A (zh) 2014-11-16
CN105008368A (zh) 2015-10-28
EA025885B1 (ru) 2017-02-28
CN105008368B (zh) 2017-02-01
PH12015501586A1 (en) 2015-10-05
MX2015009633A (es) 2015-11-30
HK1216425A1 (zh) 2016-11-11
AU2014209949A1 (en) 2015-07-30
BR112015017759A2 (pt) 2017-07-11
WO2014114694A1 (en) 2014-07-31
ES2642762T3 (es) 2017-11-20
EP2948452A1 (en) 2015-12-02
SG11201505520WA (en) 2015-08-28
MA38284B1 (fr) 2018-05-31
US20150361082A1 (en) 2015-12-17
EA201591379A1 (ru) 2016-01-29
KR20150108897A (ko) 2015-09-30
JP6306053B2 (ja) 2018-04-04
CR20150390A (es) 2015-10-19

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