AU2013341049B2 - Expression sequences - Google Patents
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- AU2013341049B2 AU2013341049B2 AU2013341049A AU2013341049A AU2013341049B2 AU 2013341049 B2 AU2013341049 B2 AU 2013341049B2 AU 2013341049 A AU2013341049 A AU 2013341049A AU 2013341049 A AU2013341049 A AU 2013341049A AU 2013341049 B2 AU2013341049 B2 AU 2013341049B2
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Classifications
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
Landscapes
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- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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| CN104312933B (zh) * | 2014-10-17 | 2017-03-29 | 江南大学 | 一种优化信号肽提高胰蛋白酶胞外分泌表达的方法 |
| CN108350447B (zh) * | 2015-08-05 | 2021-08-31 | 龙沙有限公司 | 启动子变体 |
| IL261411B2 (en) | 2016-03-02 | 2024-03-01 | Lonza Ag | Improved fermentation process |
| KR102486713B1 (ko) * | 2017-03-10 | 2023-01-10 | 볼트 쓰레즈, 인크. | 재조합 단백질을 고분비 수율로 생산하기 위한 조성물 및 방법 |
| BR112019025285A2 (pt) | 2017-05-31 | 2020-06-23 | Universität Für Bodenkultur Wien | Levedura que expressa um ciclo de calvin sintético, método de cultivo da levedura e seu uso para a produção de uma proteína de interesse ou um metabolito |
| SG11202006449RA (en) | 2018-02-12 | 2020-08-28 | Lonza Ag | Host cell for producing a protein of interest |
| US20210388037A1 (en) | 2018-11-19 | 2021-12-16 | Basf Se | Leader sequence for yeast |
| KR102495283B1 (ko) | 2019-01-11 | 2023-02-06 | 론자 리미티드 | 재조합 숙주 세포에서 탄소 공급원 조절된 단백질 생산 |
| WO2020200415A1 (en) | 2019-04-01 | 2020-10-08 | Lonza Ltd | Mut- methylotrophic yeast |
| US12270034B2 (en) | 2019-04-01 | 2025-04-08 | Universität Für Bodenkultur Wien | Mut- methylotrophic yeast |
| WO2020200414A1 (en) | 2019-04-01 | 2020-10-08 | Lonza Ltd | Protein production in mut-methylotrophic yeast |
| CN110760003A (zh) * | 2019-09-10 | 2020-02-07 | 广东药科大学 | 一种抗her3单链抗体的制备方法 |
| ES3034258T3 (en) | 2020-04-01 | 2025-08-14 | Lonza Ag | Helper factors for expressing proteins in yeast |
| CN116490517A (zh) | 2020-09-30 | 2023-07-25 | 龙沙有限公司 | 过表达翻译因子的宿主细胞 |
| EP4271794A2 (en) | 2020-12-29 | 2023-11-08 | bisy GmbH | Novel yeast strains |
| CN117794941A (zh) * | 2021-07-30 | 2024-03-29 | 赫莱纳公司 | 用于蛋白质合成和分泌的方法和组合物 |
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| WO2024141641A2 (en) * | 2022-12-30 | 2024-07-04 | Biotalys NV | Secretion signals |
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| EP0118551A1 (en) | 1982-09-15 | 1984-09-19 | Collaborative Research Inc. | Production of interferon in yeast by use of invertase promoter |
| US5010182A (en) | 1987-07-28 | 1991-04-23 | Chiron Corporation | DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides |
| CA1340772C (en) | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
| DE69133066T2 (de) | 1990-01-16 | 2003-03-06 | Centro De Ingenieria Genetica Y Biotecnologia, Cubanacan Playa | Verfahren zur Expression heterologischer Gene in der Hefe Pichia Pastoris, Expressionsverfahren und transformierte Mikroorganismen |
| US5268273A (en) | 1990-12-14 | 1993-12-07 | Phillips Petroleum Company | Pichia pastoris acid phosphatase gene, gene regions, signal sequence and expression vectors comprising same |
| DK82893D0 (da) | 1993-07-08 | 1993-07-08 | Novo Nordisk As | Peptid |
| KR20100016170A (ko) | 2007-04-20 | 2010-02-12 | 폴리문 사이언티픽 임무노이비오로기쉐 포르슝 게엠베하 | 이스트 발현 시스템 |
| US7741075B2 (en) | 2008-06-06 | 2010-06-22 | Board Of Regents Of The University Of Nebraska | Pichia pastoris PIR1 secretion signal peptide for recombinant protein expression and Pichia pastoris PIR1 and PIR2 anchor domain peptides for recombinant surface display |
| WO2010135678A1 (en) | 2009-05-22 | 2010-11-25 | Research Corporation Technologies, Inc. | Nucleic acids of pichia pastoris and use thereof for recombinant production of proteins |
| DE102009055015B4 (de) | 2009-12-18 | 2013-12-24 | Technische Universität Dresden | Hefe-Sekretionssystem auf Basis einer Signalsequenz aus der Hydrophobin 1-Gensequenz von Trichoderma reesei |
| EP2707382B1 (en) * | 2011-05-09 | 2019-07-17 | Ablynx NV | Method for the production of immunoglobulin single variable domains |
| HUE033282T2 (en) * | 2012-10-29 | 2017-11-28 | Lonza Ag | Expression sequences |
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