SG11201502745XA - Expression sequences - Google Patents

Expression sequences

Info

Publication number
SG11201502745XA
SG11201502745XA SG11201502745XA SG11201502745XA SG11201502745XA SG 11201502745X A SG11201502745X A SG 11201502745XA SG 11201502745X A SG11201502745X A SG 11201502745XA SG 11201502745X A SG11201502745X A SG 11201502745XA SG 11201502745X A SG11201502745X A SG 11201502745XA
Authority
SG
Singapore
Prior art keywords
expression sequences
sequences
expression
Prior art date
Application number
SG11201502745XA
Inventor
Brigitte Gasser
Diethard Mattanovich
Silvia Heiss
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of SG11201502745XA publication Critical patent/SG11201502745XA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76Albumins
    • C07K14/765Serum albumin, e.g. HSA
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478Aspartic endopeptidases (3.4.23)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG11201502745XA 2012-10-29 2013-10-29 Expression sequences SG11201502745XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12190361 2012-10-29
PCT/EP2013/072572 WO2014067926A1 (en) 2012-10-29 2013-10-29 Expression sequences

Publications (1)

Publication Number Publication Date
SG11201502745XA true SG11201502745XA (en) 2015-05-28

Family

ID=47115533

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201502745XA SG11201502745XA (en) 2012-10-29 2013-10-29 Expression sequences

Country Status (17)

Country Link
US (2) US10160988B2 (en)
EP (2) EP3130598B1 (en)
JP (2) JP6556625B2 (en)
KR (1) KR102079293B1 (en)
CN (1) CN104837857B (en)
AU (1) AU2013341049B2 (en)
BR (1) BR112015008289A2 (en)
CA (2) CA3212565A1 (en)
DK (1) DK2912053T3 (en)
ES (2) ES2789299T3 (en)
HK (1) HK1208037A1 (en)
HU (1) HUE033282T2 (en)
IL (2) IL238420B (en)
IN (1) IN2015DN02771A (en)
PL (1) PL2912053T3 (en)
SG (1) SG11201502745XA (en)
WO (1) WO2014067926A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104837857B (en) * 2012-10-29 2018-11-06 龙沙有限公司 Expressed sequence
CN104312933B (en) * 2014-10-17 2017-03-29 江南大学 A kind of method that optimization signal peptide improves the expression of trypsin exocytosiss
EP3332005B1 (en) 2015-08-05 2021-09-22 Lonza Ltd Promoter variants
CN109219662A (en) 2016-03-02 2019-01-15 龙沙有限公司 Improved zymotechnique
KR20240005134A (en) * 2017-03-10 2024-01-11 볼트 쓰레즈, 인크. Compositions and methods for producing high secreted yields of recombinant proteins
CN111133097A (en) 2017-05-31 2020-05-08 维也纳自然资源与生命科学大学 Yeast expressing synthetic calvin cycle
SG11202006449RA (en) 2018-02-12 2020-08-28 Lonza Ag Host cell for producing a protein of interest
CN113015782A (en) 2018-11-19 2021-06-22 巴斯夫欧洲公司 Leader sequences for yeast
CN116904331A (en) 2019-01-11 2023-10-20 龙沙有限公司 Carbon source regulated protein production in recombinant host cells
JP2022528536A (en) 2019-04-01 2022-06-14 ウニヴェルズィテート・フューア・ボーデンクルトゥーア・ウィーン Mut-Methylotrofu Yeast
WO2020200415A1 (en) 2019-04-01 2020-10-08 Lonza Ltd Mut- methylotrophic yeast
WO2020200414A1 (en) 2019-04-01 2020-10-08 Lonza Ltd Protein production in mut-methylotrophic yeast
CN110760003A (en) * 2019-09-10 2020-02-07 广东药科大学 Preparation method of anti-HER3 single-chain antibody
US20230126246A1 (en) 2020-04-01 2023-04-27 Lonza Ltd Helper factors for expressing proteins in yeast
IL301312A (en) 2020-09-30 2023-05-01 Lonza Ag Host cells overexpressing translational factors
EP4271794A2 (en) 2020-12-29 2023-11-08 bisy GmbH Novel yeast strains

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984001153A1 (en) 1982-09-15 1984-03-29 Collaborative Res Inc Production of interferon in yeast by use of invertase promoter
US5010182A (en) 1987-07-28 1991-04-23 Chiron Corporation DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides
CA1340772C (en) 1987-12-30 1999-09-28 Patricia Tekamp-Olson Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences
DE69133066T2 (en) 1990-01-16 2003-03-06 Ct Ingenieria Genetica Biotech Process for the expression of heterological genes in the yeast Pichia Pastoris, expression process and transformed microorganisms
US5268273A (en) 1990-12-14 1993-12-07 Phillips Petroleum Company Pichia pastoris acid phosphatase gene, gene regions, signal sequence and expression vectors comprising same
DK82893D0 (en) 1993-07-08 1993-07-08 Novo Nordisk As PEPTIDE
JP2010524440A (en) 2007-04-20 2010-07-22 ポリマン サイエンティフィック イミューンバイオロジッシュ フォーシュング ゲゼルシャフト ミット ベシュレンクテル ファフツング Expression system
US7741075B2 (en) 2008-06-06 2010-06-22 Board Of Regents Of The University Of Nebraska Pichia pastoris PIR1 secretion signal peptide for recombinant protein expression and Pichia pastoris PIR1 and PIR2 anchor domain peptides for recombinant surface display
WO2010135678A1 (en) 2009-05-22 2010-11-25 Research Corporation Technologies, Inc. Nucleic acids of pichia pastoris and use thereof for recombinant production of proteins
EP2258855A1 (en) * 2009-05-28 2010-12-08 Universität für Bodenkultur Wien Expression sequences
DE102009055015B4 (en) 2009-12-18 2013-12-24 Technische Universität Dresden Yeast secretion system based on a signal sequence from the hydrophobin 1 gene sequence of Trichoderma reesei
WO2012152823A1 (en) * 2011-05-09 2012-11-15 Ablynx Nv Method for the production of immunoglobulin single variable domains
CN104837857B (en) * 2012-10-29 2018-11-06 龙沙有限公司 Expressed sequence

Also Published As

Publication number Publication date
EP2912053A1 (en) 2015-09-02
EP3130598B1 (en) 2020-02-12
EP2912053B1 (en) 2016-11-09
US10160988B2 (en) 2018-12-25
IL266700A (en) 2019-07-31
US20180135092A1 (en) 2018-05-17
KR102079293B1 (en) 2020-02-19
DK2912053T3 (en) 2017-01-30
US20150232904A1 (en) 2015-08-20
KR20150076160A (en) 2015-07-06
CA2886460C (en) 2023-11-14
ES2789299T3 (en) 2020-10-26
JP2015533286A (en) 2015-11-24
EP3130598A2 (en) 2017-02-15
AU2013341049B2 (en) 2017-07-20
CN104837857A (en) 2015-08-12
WO2014067926A1 (en) 2014-05-08
IL238420A0 (en) 2015-06-30
HUE033282T2 (en) 2017-11-28
BR112015008289A2 (en) 2017-11-28
CA3212565A1 (en) 2014-05-08
JP2019141063A (en) 2019-08-29
IN2015DN02771A (en) 2015-09-04
EP3130598A3 (en) 2017-05-03
IL266700B (en) 2021-08-31
IL238420B (en) 2019-05-30
US11359223B2 (en) 2022-06-14
PL2912053T3 (en) 2017-05-31
CA2886460A1 (en) 2014-05-08
JP6556625B2 (en) 2019-08-07
CN104837857B (en) 2018-11-06
AU2013341049A1 (en) 2015-04-02
HK1208037A1 (en) 2016-02-19
ES2610990T3 (en) 2017-05-04

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