AU2013292149B2 - Pyridinone derivatives as tissue transglutaminase inhibitors - Google Patents
Pyridinone derivatives as tissue transglutaminase inhibitors Download PDFInfo
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- AU2013292149B2 AU2013292149B2 AU2013292149A AU2013292149A AU2013292149B2 AU 2013292149 B2 AU2013292149 B2 AU 2013292149B2 AU 2013292149 A AU2013292149 A AU 2013292149A AU 2013292149 A AU2013292149 A AU 2013292149A AU 2013292149 B2 AU2013292149 B2 AU 2013292149B2
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- Australia
- Prior art keywords
- oxo
- ylamino
- dihydropyridin
- oxoethyl
- enoate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- BNWCETAHAJSBFG-UHFFFAOYSA-N CC(C)(C)OC(CBr)=O Chemical compound CC(C)(C)OC(CBr)=O BNWCETAHAJSBFG-UHFFFAOYSA-N 0.000 description 1
- WZZOGVWXGGUWJV-UHFFFAOYSA-N CC(C)(C)OC(CN(C=CC=C1NC(OCc2ccccc2)=O)C1=O)=O Chemical compound CC(C)(C)OC(CN(C=CC=C1NC(OCc2ccccc2)=O)C1=O)=O WZZOGVWXGGUWJV-UHFFFAOYSA-N 0.000 description 1
- XCHRIVFDVWQPRZ-UHFFFAOYSA-N CCC(CC)CNC(CN(C=CC=C1N)C1=O)=O Chemical compound CCC(CC)CNC(CN(C=CC=C1N)C1=O)=O XCHRIVFDVWQPRZ-UHFFFAOYSA-N 0.000 description 1
- RBVQOYSIGWNEOO-UHFFFAOYSA-N CCC(CC)CNC(CN(C=CC=C1NC(OCc2ccccc2)=O)C1=O)=O Chemical compound CCC(CC)CNC(CN(C=CC=C1NC(OCc2ccccc2)=O)C1=O)=O RBVQOYSIGWNEOO-UHFFFAOYSA-N 0.000 description 1
- OZGRHZALYYMAMN-ATEOEAFZSA-N CCC(CC)CNC(CN(C=CC=C1NC([C@H](CC/C=C/C(OC)=O)NC(OC(C)(C)C)=O)=O)C1=O)=O Chemical compound CCC(CC)CNC(CN(C=CC=C1NC([C@H](CC/C=C/C(OC)=O)NC(OC(C)(C)C)=O)=O)C1=O)=O OZGRHZALYYMAMN-ATEOEAFZSA-N 0.000 description 1
- VHGWUSABWIEXKQ-BEBFYNPSSA-N CCC(CC)CNC(CN(C=CC=C1NC([C@H](CC/C=C/C(OC)=O)NC(c2cnc[n]2C)=O)=O)C1=O)=O Chemical compound CCC(CC)CNC(CN(C=CC=C1NC([C@H](CC/C=C/C(OC)=O)NC(c2cnc[n]2C)=O)=O)C1=O)=O VHGWUSABWIEXKQ-BEBFYNPSSA-N 0.000 description 1
- HCOXTMQFPXVEPG-UHFFFAOYSA-N OC(CN(C=CC=C1NC(OCc2ccccc2)=O)C1=O)=O Chemical compound OC(CN(C=CC=C1NC(OCc2ccccc2)=O)C1=O)=O HCOXTMQFPXVEPG-UHFFFAOYSA-N 0.000 description 1
- UEYQJQVBUVAELZ-UHFFFAOYSA-N OC(c1cccnc1O)=O Chemical compound OC(c1cccnc1O)=O UEYQJQVBUVAELZ-UHFFFAOYSA-N 0.000 description 1
- MAJFINHRLBJIQL-UHFFFAOYSA-N Oc1ncccc1NC(OCc1ccccc1)=O Chemical compound Oc1ncccc1NC(OCc1ccccc1)=O MAJFINHRLBJIQL-UHFFFAOYSA-N 0.000 description 1
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12176776.8 | 2012-07-17 | ||
EP12176776.8A EP2687511A1 (de) | 2012-07-17 | 2012-07-17 | Pyridinonderivate als Gewebetransglutaminaseinhibitoren |
US201261741871P | 2012-07-30 | 2012-07-30 | |
US61/741,871 | 2012-07-30 | ||
PCT/EP2013/064789 WO2014012858A1 (de) | 2012-07-17 | 2013-07-12 | Pyridinonderivate als gewebetransglutaminaseinhibitoren |
Publications (2)
Publication Number | Publication Date |
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AU2013292149A1 AU2013292149A1 (en) | 2015-02-05 |
AU2013292149B2 true AU2013292149B2 (en) | 2016-11-24 |
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Application Number | Title | Priority Date | Filing Date |
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AU2013292149A Active AU2013292149B2 (en) | 2012-07-17 | 2013-07-12 | Pyridinone derivatives as tissue transglutaminase inhibitors |
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Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
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EP3331881B1 (en) | 2015-08-05 | 2019-05-15 | ratiopharm GmbH | New crystalline form and acetic acid adducts of palbociclib |
WO2019201432A1 (en) * | 2018-04-17 | 2019-10-24 | Zedira Gmbh | Inhibitors of blood coagulation factor xiii |
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JP2013180955A (ja) * | 2012-02-29 | 2013-09-12 | Toray Ind Inc | 組織トランスグルタミナーゼ阻害剤並びにカルコン誘導体及びその医薬用途 |
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EP2797892B1 (de) | 2015-05-27 |
SI2797892T1 (sl) | 2015-09-30 |
IL236707B (en) | 2018-12-31 |
WO2014012858A1 (de) | 2014-01-23 |
AU2013292149A1 (en) | 2015-02-05 |
DK2797892T3 (en) | 2015-07-20 |
IL236707A0 (en) | 2015-02-26 |
CN104603109A (zh) | 2015-05-06 |
JP6236445B2 (ja) | 2017-11-22 |
JP2015529645A (ja) | 2015-10-08 |
SMT201500208B (it) | 2015-10-30 |
PL2797892T3 (pl) | 2015-10-30 |
CY1116775T1 (el) | 2017-03-15 |
EP2687511A1 (de) | 2014-01-22 |
IN2015DN01151A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-06-26 |
CN104603109B (zh) | 2017-07-28 |
PT2797892E (pt) | 2015-09-18 |
US9434763B2 (en) | 2016-09-06 |
US20150203535A1 (en) | 2015-07-23 |
ES2543956T3 (es) | 2015-08-26 |
RS54153B1 (en) | 2015-12-31 |
HUE027051T2 (en) | 2016-08-29 |
EP2797892A1 (de) | 2014-11-05 |
HRP20150829T1 (hr) | 2015-09-11 |
CA2878796C (en) | 2018-10-23 |
RU2015104969A (ru) | 2016-09-10 |
CA2878796A1 (en) | 2014-01-23 |
RU2652987C2 (ru) | 2018-05-04 |
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