AU2013287353B2 - Oligonucleotides for making a change in the sequence of a target RNA molecule present in a living cell - Google Patents

Oligonucleotides for making a change in the sequence of a target RNA molecule present in a living cell Download PDF

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Publication number
AU2013287353B2
AU2013287353B2 AU2013287353A AU2013287353A AU2013287353B2 AU 2013287353 B2 AU2013287353 B2 AU 2013287353B2 AU 2013287353 A AU2013287353 A AU 2013287353A AU 2013287353 A AU2013287353 A AU 2013287353A AU 2013287353 B2 AU2013287353 B2 AU 2013287353B2
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rna
seq
artificial
oligonucleotide
cftr
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AU2013287353A1 (en
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Daniel Anton DE BOER
Tita RITSEMA
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ProQR Therapeutics II BV
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2320/00—Applications; Uses
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    • C12N2320/31—Combination therapy
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/34—Allele or polymorphism specific uses

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  • General Engineering & Computer Science (AREA)
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  • Physics & Mathematics (AREA)
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  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2013287353A 2012-07-12 2013-07-12 Oligonucleotides for making a change in the sequence of a target RNA molecule present in a living cell Ceased AU2013287353B2 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201261670681P 2012-07-12 2012-07-12
US61/670,681 2012-07-12
US201261718801P 2012-10-26 2012-10-26
US61/718,801 2012-10-26
EP13166465 2013-05-03
EP13166465.8 2013-05-03
EP13172515 2013-06-18
EP13172515.2 2013-06-18
EP13173818 2013-06-26
EP13173818.9 2013-06-26
PCT/NL2013/050534 WO2014011053A1 (en) 2012-07-12 2013-07-12 Oligonucleotides for making a change in the sequence of a target rna molecule present in a living cell

Publications (2)

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AU2013287353A1 AU2013287353A1 (en) 2015-02-26
AU2013287353B2 true AU2013287353B2 (en) 2018-11-08

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AU2013287353A Ceased AU2013287353B2 (en) 2012-07-12 2013-07-12 Oligonucleotides for making a change in the sequence of a target RNA molecule present in a living cell

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EP (2) EP3103872B1 (enExample)
JP (1) JP6373833B2 (enExample)
KR (1) KR20150037968A (enExample)
CN (1) CN104640986B (enExample)
AU (1) AU2013287353B2 (enExample)
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CA (1) CA2878934A1 (enExample)
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HR (1) HRP20160854T1 (enExample)
HU (1) HUE029977T2 (enExample)
IL (1) IL236654B (enExample)
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NZ (1) NZ703824A (enExample)
PL (1) PL2852668T3 (enExample)
PT (1) PT2852668T (enExample)
RS (1) RS54944B1 (enExample)
RU (1) RU2663110C2 (enExample)
SI (1) SI2852668T1 (enExample)
SM (1) SMT201600234B (enExample)
WO (1) WO2014011053A1 (enExample)

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WO2014011053A1 (en) 2012-07-12 2014-01-16 Proqr Therapeutics B.V. Oligonucleotides for making a change in the sequence of a target rna molecule present in a living cell
PT3131582T (pt) 2014-04-15 2018-10-08 Vertex Pharma Composições farmacêuticas para o tratamento de doenças mediadas pelo regulador de condutância transmembranar da fibrose quística
RU2771104C2 (ru) 2014-05-14 2022-04-26 Таргиммьюн Терапьютикс Аг Улучшенные полиэтилениминовые полиэтиленгликолевые векторы
CN107250113B (zh) 2014-10-07 2019-03-29 弗特克斯药品有限公司 囊性纤维化跨膜传导调节蛋白的调节剂的共晶
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DK3234134T3 (da) * 2014-12-17 2020-07-27 Proqr Therapeutics Ii Bv Målrettet rna-redigering
US20210401869A1 (en) * 2015-02-20 2021-12-30 Rosalind Franklin University Of Medicine And Science Antisense Compounds Targeting Genes Associated with Cystic Fibrosis
GB201507926D0 (en) * 2015-05-08 2015-06-24 Proqr Therapeutics N V Improved treatments using oligonucleotides
KR20180053753A (ko) 2015-10-05 2018-05-23 프로큐알 테라퓨틱스 Ⅱ 비.브이. 삼핵산 반복 확장과 관련된 유전질환의 예방 또는 치료용 단일 가닥 안티센스 올리고뉴클레오타이드의 용도
EP3985116A1 (en) 2015-10-15 2022-04-20 City of Hope Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof
CA3022319A1 (en) * 2016-05-06 2017-11-09 Tod M. Woolf Improved methods for genome editing with and without programmable nucleases
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ES2837076T3 (es) 2016-09-01 2021-06-29 Proqr Therapeutics Ii Bv Oligonucleótidos para la edición de ARN de cadena sencilla modificados químicamente
US11274300B2 (en) 2017-01-19 2022-03-15 Proqr Therapeutics Ii B.V. Oligonucleotide complexes for use in RNA editing
JP2020508685A (ja) 2017-03-03 2020-03-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング
CN107267516B (zh) * 2017-07-28 2020-09-29 佛山科学技术学院 双sgRNA介导的基因精确修饰方法及应用
EP3697904A1 (en) 2017-10-17 2020-08-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Combination treatment for cystic fibrosis
CN110573184B (zh) * 2018-02-09 2025-05-13 俄亥俄州立创新基金会 Rna纳米结构，其制备方法和用途
AU2019243946B2 (en) 2018-03-27 2025-03-06 Proqr Therapeutics Ii B.V. Nucleic acid molecules for pseudouridylation
GB201808146D0 (en) 2018-05-18 2018-07-11 Proqr Therapeutics Ii Bv Stereospecific Linkages in RNA Editing Oligonucleotides
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CN113397996A (zh) * 2021-07-23 2021-09-17 河南省人民医院 一种抗菌漱口水及其制备方法
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BR112015000710A2 (enExample) 2017-08-15
EP3103872A1 (en) 2016-12-14
RS54944B1 (sr) 2016-11-30
JP2015523082A (ja) 2015-08-13
IL236654B (en) 2018-02-28
DK3103872T3 (en) 2018-10-22
MX356625B (es) 2018-06-06
CY1117858T1 (el) 2017-05-17
HRP20160854T1 (hr) 2016-09-23
AU2013287353A1 (en) 2015-02-26
RU2663110C2 (ru) 2018-08-01
DK2852668T3 (en) 2016-05-30
CN104640986B (zh) 2018-08-28
KR20150037968A (ko) 2015-04-08
EP2852668A1 (en) 2015-04-01
US20170152518A1 (en) 2017-06-01
IL236654A0 (en) 2015-02-26
HK1208491A1 (zh) 2016-03-04
CA2878934A1 (en) 2014-01-16
MX2015000506A (es) 2015-06-03
PT2852668T (pt) 2016-07-13
ES2584856T3 (es) 2016-09-29
SI2852668T1 (sl) 2016-09-30
CN104640986A (zh) 2015-05-20
US9605255B2 (en) 2017-03-28
EP3103872B1 (en) 2018-08-29
JP6373833B2 (ja) 2018-08-15
WO2014011053A1 (en) 2014-01-16
HUE029977T2 (en) 2017-04-28
ES2698522T3 (es) 2019-02-05
US9994856B2 (en) 2018-06-12
NZ703824A (en) 2018-06-29
PL2852668T3 (pl) 2016-11-30
EP2852668B1 (en) 2016-04-27
SMT201600234B (it) 2016-08-31
US20150197744A1 (en) 2015-07-16
BR112015000710A8 (pt) 2018-04-03
RU2015104763A (ru) 2016-08-27

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