AU2013240340B2 - PFKFB3 inhibitor and methods of use as an anti-cancer therapeutic - Google Patents
PFKFB3 inhibitor and methods of use as an anti-cancer therapeutic Download PDFInfo
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- AU2013240340B2 AU2013240340B2 AU2013240340A AU2013240340A AU2013240340B2 AU 2013240340 B2 AU2013240340 B2 AU 2013240340B2 AU 2013240340 A AU2013240340 A AU 2013240340A AU 2013240340 A AU2013240340 A AU 2013240340A AU 2013240340 B2 AU2013240340 B2 AU 2013240340B2
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- cancers
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- quinolin
- prop
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261617073P | 2012-03-29 | 2012-03-29 | |
| US61/617,073 | 2012-03-29 | ||
| PCT/US2013/031159 WO2013148228A1 (en) | 2012-03-29 | 2013-03-14 | Pfkfb3 inhibitor and methods of use as an anti-cancer therapeutic |
Publications (2)
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| AU2013240340A1 AU2013240340A1 (en) | 2014-10-23 |
| AU2013240340B2 true AU2013240340B2 (en) | 2016-11-10 |
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| AU2013240340A Ceased AU2013240340B2 (en) | 2012-03-29 | 2013-03-14 | PFKFB3 inhibitor and methods of use as an anti-cancer therapeutic |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| MA40035A (fr) | 2014-10-14 | 2016-04-21 | Dana Farber Cancer Inst Inc | Molécules d'anticorps de pd-l1 et leurs utilisations |
| CN107635986A (zh) * | 2015-05-13 | 2018-01-26 | 赛尔维他股份公司 | 取代的喹喔啉衍生物 |
| WO2016191660A1 (en) * | 2015-05-28 | 2016-12-01 | University Of Louisville Research Foundation, Inc. | Combinations of pfkfb3 inhibitors and immune checkpoint inhibitors to treat cancer |
| ES2878188T3 (es) | 2015-07-29 | 2021-11-18 | Novartis Ag | Terapias de combinación que comprenden moléculas de anticuerpos contra LAG-3 |
| US20180222982A1 (en) | 2015-07-29 | 2018-08-09 | Novartis Ag | Combination therapies comprising antibody molecules to pd-1 |
| US20180207273A1 (en) | 2015-07-29 | 2018-07-26 | Novartis Ag | Combination therapies comprising antibody molecules to tim-3 |
| BR112018012138A2 (pt) | 2015-12-17 | 2018-12-04 | Novartis Ag | moléculas de anticorpo para pd-1 e usos das mesmas |
| CA3042988A1 (en) * | 2016-11-08 | 2018-05-17 | Merck Patent Gmbh | Substituted quinoxaline derivatives as inhibitors of pfkfb |
| CN109136206B (zh) * | 2017-06-15 | 2021-07-23 | 厦门大学 | Pfkfb3蛋白的第194位酪氨酸的磷酸化及其应用 |
| CN109134434B (zh) * | 2017-11-06 | 2021-02-19 | 北京大学深圳研究生院 | 喹啉或喹唑啉类化合物及其制备方法和应用 |
| BR112022002218A2 (pt) * | 2019-08-06 | 2022-06-07 | Univ North Carolina Chapel Hill | Ligantes com direcionamento a rna, composições dos mesmos e métodos de fabricação e uso dos mesmos |
| CN111228265A (zh) * | 2020-02-10 | 2020-06-05 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | p38γ抑制剂在制备治疗胰腺癌药物中的应用 |
| KR102344676B1 (ko) | 2020-02-12 | 2021-12-30 | 한국과학기술연구원 | 타우 응집체에 선택적으로 결합하는 근적외선 형광 탐침자로서 유효한 신규 화합물 및 이의 제조방법 |
| CN111996247B (zh) * | 2020-08-27 | 2021-09-10 | 北京大学人民医院 | 糖酵解抑制剂及其在修复内皮细胞损伤中的应用 |
| CN114617884B (zh) * | 2020-12-10 | 2023-06-02 | 中国科学院大连化学物理研究所 | Pfk-158在制备抗冠状病毒药物中的应用及药物 |
| EP4340897A4 (en) * | 2021-05-16 | 2025-04-09 | Metanoia Bio Inc. | Methods and compositions for treating pancreatic and hepatic disease |
| JP2025505975A (ja) * | 2022-01-31 | 2025-03-05 | ニュー フロンティア バイオ インコーポレイテッド | ニコチネート及びニコチンアミドリボシドベースの化合物及びその誘導体 |
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| US20090074884A1 (en) * | 2007-06-18 | 2009-03-19 | University Of Louisville Research Foundation, Inc. | Family of pfkfb3 inhibitors with anti-neoplastic activities |
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| US7034013B2 (en) * | 2001-03-20 | 2006-04-25 | Cydex, Inc. | Formulations containing propofol and a sulfoalkyl ether cyclodextrin |
| CN1182846C (zh) * | 2003-03-14 | 2005-01-05 | 南开大学 | 水溶性抗癌药紫杉醇复合物及其制备方法 |
| CN1554336A (zh) * | 2003-12-23 | 2004-12-15 | 广州国桥医药研究有限公司 | 水溶性青蒿素制剂的制备方法 |
| JP4790704B2 (ja) * | 2004-04-12 | 2011-10-12 | トレント・ファーマシューティカルズ・リミテッド | Ｈｓｐ７０誘発因子としての２−プロペン−１−オン |
| CN101020060A (zh) * | 2007-03-10 | 2007-08-22 | 杨喜鸿 | 恩替卡韦的环糊精包合物及其制备方法和药物应用 |
| US8916711B2 (en) * | 2009-10-13 | 2014-12-23 | Council Of Scientific And Industrial Research | Imidazothiazole-chalcone derivatives as potential anticancer agents and process for the preparation thereof |
| CN102000080A (zh) * | 2010-09-21 | 2011-04-06 | 江苏先声药物研究有限公司 | 一种喜树碱类化合物的增溶方法 |
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- 2013-03-14 EP EP13770319.5A patent/EP2831047B1/en not_active Not-in-force
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- 2013-03-14 JP JP2015503286A patent/JP6075903B2/ja not_active Expired - Fee Related
- 2013-03-14 CN CN201380024610.9A patent/CN104520274B/zh not_active Expired - Fee Related
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20090074884A1 (en) * | 2007-06-18 | 2009-03-19 | University Of Louisville Research Foundation, Inc. | Family of pfkfb3 inhibitors with anti-neoplastic activities |
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| CA2868787A1 (en) | 2013-10-03 |
| US20150064175A1 (en) | 2015-03-05 |
| IN2014DN08886A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-05-22 |
| US10010542B2 (en) | 2018-07-03 |
| US20170258783A1 (en) | 2017-09-14 |
| CN104520274A (zh) | 2015-04-15 |
| EP2831047A4 (en) | 2015-09-02 |
| JP2015512398A (ja) | 2015-04-27 |
| US9649305B2 (en) | 2017-05-16 |
| ES2629932T3 (es) | 2017-08-16 |
| CN106074368A (zh) | 2016-11-09 |
| EP2831047B1 (en) | 2017-05-03 |
| JP6075903B2 (ja) | 2017-02-08 |
| CN104520274B (zh) | 2016-08-24 |
| WO2013148228A1 (en) | 2013-10-03 |
| EP2831047A1 (en) | 2015-02-04 |
| AU2013240340A1 (en) | 2014-10-23 |
| CN106074368B (zh) | 2019-01-22 |
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