AU2012335663B2 - Method of treating a proliferative disease - Google Patents

Method of treating a proliferative disease Download PDF

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Publication number
AU2012335663B2
AU2012335663B2 AU2012335663A AU2012335663A AU2012335663B2 AU 2012335663 B2 AU2012335663 B2 AU 2012335663B2 AU 2012335663 A AU2012335663 A AU 2012335663A AU 2012335663 A AU2012335663 A AU 2012335663A AU 2012335663 B2 AU2012335663 B2 AU 2012335663B2
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Australia
Prior art keywords
braf
treatment
braf inhibitor
weeks
mutation
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AU2012335663A
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AU2012335663A1 (en
Inventor
Darrin Stuart
Meghna Das THAKUR
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Array Biopharma Inc
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Array Biopharma Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2012335663A 2011-11-11 2012-11-09 Method of treating a proliferative disease Active AU2012335663B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161558619P 2011-11-11 2011-11-11
US61/558,619 2011-11-11
PCT/US2012/064269 WO2013070996A1 (en) 2011-11-11 2012-11-09 Method of treating a proliferative disease

Publications (2)

Publication Number Publication Date
AU2012335663A1 AU2012335663A1 (en) 2014-05-29
AU2012335663B2 true AU2012335663B2 (en) 2015-12-24

Family

ID=47279036

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012335663A Active AU2012335663B2 (en) 2011-11-11 2012-11-09 Method of treating a proliferative disease

Country Status (10)

Country Link
US (1) US11007194B2 (OSRAM)
EP (1) EP2776037B1 (OSRAM)
JP (1) JP6150813B2 (OSRAM)
CN (2) CN103917236A (OSRAM)
AU (1) AU2012335663B2 (OSRAM)
BR (1) BR112014011223A8 (OSRAM)
CA (1) CA2855243C (OSRAM)
MX (1) MX354725B (OSRAM)
RU (1) RU2622015C2 (OSRAM)
WO (1) WO2013070996A1 (OSRAM)

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WO2018107146A1 (en) * 2016-12-11 2018-06-14 Memorial Sloan Kettering Cancer Center Methods and compositions for treatment of braf mutant cancers
US12076320B2 (en) 2018-07-12 2024-09-03 Shenzhen Targetrx, Inc. Diarylpyrazole compound, composition comprising same, and use thereof
TWI817018B (zh) 2019-06-28 2023-10-01 美商艾瑞生藥股份有限公司 用於治療ｂｒａｆ相關的疾病和失調症之化合物
WO2021142026A1 (en) * 2020-01-07 2021-07-15 Revolution Medicines, Inc. Shp2 inhibitor dosing and methods of treating cancer
US12303509B2 (en) 2020-06-09 2025-05-20 Pfizer Inc. Compounds for the treatment of BRAF-associated diseases and disorders
WO2023230554A1 (en) 2022-05-25 2023-11-30 Pfizer Inc. Combination of a braf inhibitor, an egfr inhibitor, and a pd-1 antagonist for the treatment of braf v600e-mutant, msi-h/dmmr colorectal cancer
AU2024204522B1 (en) 2023-03-09 2024-08-22 Minneamrita Therapeutics Llc Drug combination for treatment of gastric cancer
WO2025003956A1 (en) 2023-06-30 2025-01-02 Pfizer Inc. High drug loading formulations of encorafenib

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Also Published As

Publication number Publication date
JP6150813B2 (ja) 2017-06-21
HK1198920A1 (en) 2015-06-19
US20140275136A1 (en) 2014-09-18
WO2013070996A1 (en) 2013-05-16
JP2014533272A (ja) 2014-12-11
BR112014011223A2 (pt) 2017-05-09
EP2776037B1 (en) 2019-01-09
MX2014005726A (es) 2014-05-28
US11007194B2 (en) 2021-05-18
RU2014117707A (ru) 2015-12-20
CN108542906A (zh) 2018-09-18
CA2855243C (en) 2020-04-14
EP2776037A1 (en) 2014-09-17
RU2622015C2 (ru) 2017-06-08
AU2012335663A1 (en) 2014-05-29
CA2855243A1 (en) 2013-05-16
BR112014011223A8 (pt) 2023-01-31
MX354725B (es) 2018-03-16
CN103917236A (zh) 2014-07-09

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