AU2012323287B2 - A method for purifying antibodies - Google Patents

A method for purifying antibodies Download PDF

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Publication number
AU2012323287B2
AU2012323287B2 AU2012323287A AU2012323287A AU2012323287B2 AU 2012323287 B2 AU2012323287 B2 AU 2012323287B2 AU 2012323287 A AU2012323287 A AU 2012323287A AU 2012323287 A AU2012323287 A AU 2012323287A AU 2012323287 B2 AU2012323287 B2 AU 2012323287B2
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AU
Australia
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val
pro
thr
lys
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AU2012323287A
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English (en)
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AU2012323287A1 (en
Inventor
Matthew J. Bernett
John Desjarlais
Gregory L. Moore
Rumana RASHID
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Xencor Inc
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Xencor Inc
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Publication of AU2012323287A1 publication Critical patent/AU2012323287A1/en
Application granted granted Critical
Publication of AU2012323287B2 publication Critical patent/AU2012323287B2/en
Priority to AU2018202978A priority Critical patent/AU2018202978B2/en
Priority to AU2020207803A priority patent/AU2020207803A1/en
Priority to AU2023270275A priority patent/AU2023270275A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2012323287A 2011-10-10 2012-10-10 A method for purifying antibodies Ceased AU2012323287B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2018202978A AU2018202978B2 (en) 2011-10-10 2018-04-30 A method for purifying antibodies
AU2020207803A AU2020207803A1 (en) 2011-10-10 2020-07-21 A method for purifying antibodies
AU2023270275A AU2023270275A1 (en) 2011-10-10 2023-11-22 A method for purifying antibodies

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161545498P 2011-10-10 2011-10-10
US61/545,498 2011-10-10
US201261593846P 2012-02-01 2012-02-01
US61/593,846 2012-02-01
US201261598686P 2012-02-14 2012-02-14
US61/598,686 2012-02-14
US201213568028A 2012-08-06 2012-08-06
US13/568,028 2012-08-06
PCT/US2012/059582 WO2013055809A1 (en) 2011-10-10 2012-10-10 A method for purifying antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018202978A Division AU2018202978B2 (en) 2011-10-10 2018-04-30 A method for purifying antibodies

Publications (2)

Publication Number Publication Date
AU2012323287A1 AU2012323287A1 (en) 2014-05-29
AU2012323287B2 true AU2012323287B2 (en) 2018-02-01

Family

ID=47146686

Family Applications (4)

Application Number Title Priority Date Filing Date
AU2012323287A Ceased AU2012323287B2 (en) 2011-10-10 2012-10-10 A method for purifying antibodies
AU2018202978A Active AU2018202978B2 (en) 2011-10-10 2018-04-30 A method for purifying antibodies
AU2020207803A Abandoned AU2020207803A1 (en) 2011-10-10 2020-07-21 A method for purifying antibodies
AU2023270275A Pending AU2023270275A1 (en) 2011-10-10 2023-11-22 A method for purifying antibodies

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2018202978A Active AU2018202978B2 (en) 2011-10-10 2018-04-30 A method for purifying antibodies
AU2020207803A Abandoned AU2020207803A1 (en) 2011-10-10 2020-07-21 A method for purifying antibodies
AU2023270275A Pending AU2023270275A1 (en) 2011-10-10 2023-11-22 A method for purifying antibodies

Country Status (6)

Country Link
EP (2) EP2766392B1 (https=)
JP (3) JP6310394B2 (https=)
AU (4) AU2012323287B2 (https=)
CA (2) CA2851534C (https=)
DK (1) DK2766392T3 (https=)
WO (1) WO2013055809A1 (https=)

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