AU2012240102C1 - Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (GDF-15) - Google Patents

Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (GDF-15) Download PDF

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Publication number
AU2012240102C1
AU2012240102C1 AU2012240102A AU2012240102A AU2012240102C1 AU 2012240102 C1 AU2012240102 C1 AU 2012240102C1 AU 2012240102 A AU2012240102 A AU 2012240102A AU 2012240102 A AU2012240102 A AU 2012240102A AU 2012240102 C1 AU2012240102 C1 AU 2012240102C1
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gdf15
polypeptide
subject
mice
levels
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AU2012240102B2 (en
AU2012240102A1 (en
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Yang Li
Bei Shan
Jackie Zeqi SHENG
Yumei Xiong
Wen-Chen Yeh
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Amgen Inc
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Amgen Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2012240102A 2011-04-08 2012-04-05 Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (GDF-15) Active AU2012240102C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161473583P 2011-04-08 2011-04-08
US61/473,583 2011-04-08
PCT/US2012/032415 WO2012138919A2 (en) 2011-04-08 2012-04-05 Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15)

Publications (3)

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AU2012240102A1 AU2012240102A1 (en) 2013-10-17
AU2012240102B2 AU2012240102B2 (en) 2016-04-14
AU2012240102C1 true AU2012240102C1 (en) 2016-09-08

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US (2) US10752664B2 (enExample)
EP (1) EP2694092B1 (enExample)
JP (1) JP5977814B2 (enExample)
CN (1) CN103533951B (enExample)
AU (1) AU2012240102C1 (enExample)
CA (1) CA2832581C (enExample)
MX (1) MX343729B (enExample)
WO (1) WO2012138919A2 (enExample)

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US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
WO2014085365A2 (en) 2012-11-28 2014-06-05 Ngm Biopharmaceuticals, Inc. Compositions and methods for treatment of metabolic disorders and diseases
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US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
US9161966B2 (en) 2013-01-30 2015-10-20 Ngm Biopharmaceuticals, Inc. GDF15 mutein polypeptides
EP2950807B1 (en) * 2013-01-30 2018-03-28 NGM Biopharmaceuticals, Inc. Compositions and methods of use in treating metabolic disorders
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WO2015183890A2 (en) 2014-05-28 2015-12-03 Ngm Biopharmaceuticals, Inc. Methods and compositions for the treatment of metabolic disorders and diseases
WO2015195509A2 (en) 2014-06-16 2015-12-23 Ngm Biopharmaceuticals, Inc. Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
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AU2012240102B2 (en) 2016-04-14
JP2014511863A (ja) 2014-05-19
WO2012138919A2 (en) 2012-10-11
MX343729B (es) 2016-11-18
WO2012138919A3 (en) 2013-01-17
US20200325200A1 (en) 2020-10-15
CN103533951A (zh) 2014-01-22
EP2694092A2 (en) 2014-02-12
EP2694092B1 (en) 2017-01-04
US10752664B2 (en) 2020-08-25
CA2832581A1 (en) 2012-10-11
CN103533951B (zh) 2017-04-19
US20150307575A1 (en) 2015-10-29
CA2832581C (en) 2022-08-23
AU2012240102A1 (en) 2013-10-17
JP5977814B2 (ja) 2016-08-24
WO2012138919A9 (en) 2013-03-07
MX2013011726A (es) 2014-03-27

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