AU2012240102C1 - Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (GDF-15) - Google Patents

Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (GDF-15) Download PDF

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Publication number
AU2012240102C1
AU2012240102C1 AU2012240102A AU2012240102A AU2012240102C1 AU 2012240102 C1 AU2012240102 C1 AU 2012240102C1 AU 2012240102 A AU2012240102 A AU 2012240102A AU 2012240102 A AU2012240102 A AU 2012240102A AU 2012240102 C1 AU2012240102 C1 AU 2012240102C1
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AU
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gdf15
polypeptide
subject
mice
levels
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AU2012240102B2 (en
AU2012240102A1 (en
Inventor
Yang Li
Bei Shan
Jackie Zeqi SHENG
Yumei Xiong
Wen-Chen Yeh
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Amgen Inc
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Amgen Inc
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Publication of AU2012240102B2 publication Critical patent/AU2012240102B2/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/495Transforming growth factor [TGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2012240102A 2011-04-08 2012-04-05 Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (GDF-15) Active AU2012240102C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161473583P 2011-04-08 2011-04-08
US61/473,583 2011-04-08
PCT/US2012/032415 WO2012138919A2 (en) 2011-04-08 2012-04-05 Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15)

Publications (3)

Publication Number Publication Date
AU2012240102A1 AU2012240102A1 (en) 2013-10-17
AU2012240102B2 AU2012240102B2 (en) 2016-04-14
AU2012240102C1 true AU2012240102C1 (en) 2016-09-08

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AU2012240102A Active AU2012240102C1 (en) 2011-04-08 2012-04-05 Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (GDF-15)

Country Status (8)

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US (2) US10752664B2 (enExample)
EP (1) EP2694092B1 (enExample)
JP (1) JP5977814B2 (enExample)
CN (1) CN103533951B (enExample)
AU (1) AU2012240102C1 (enExample)
CA (1) CA2832581C (enExample)
MX (1) MX343729B (enExample)
WO (1) WO2012138919A2 (enExample)

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US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
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WO2014120619A2 (en) * 2013-01-30 2014-08-07 Ngm Biopharmaceuticals, Inc. Compositions and methods of use in treating metabolic disorders
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WO2012138919A9 (en) 2013-03-07
US10752664B2 (en) 2020-08-25
WO2012138919A3 (en) 2013-01-17
CA2832581A1 (en) 2012-10-11
US20200325200A1 (en) 2020-10-15
CN103533951A (zh) 2014-01-22
MX2013011726A (es) 2014-03-27
CN103533951B (zh) 2017-04-19
JP5977814B2 (ja) 2016-08-24
WO2012138919A2 (en) 2012-10-11
JP2014511863A (ja) 2014-05-19
AU2012240102B2 (en) 2016-04-14
CA2832581C (en) 2022-08-23
EP2694092B1 (en) 2017-01-04
US20150307575A1 (en) 2015-10-29
EP2694092A2 (en) 2014-02-12
AU2012240102A1 (en) 2013-10-17
MX343729B (es) 2016-11-18

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Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 26 MAY 2016 .

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 26 MAY 2016

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