AU2011262308B2 - Methods and compositions for oral pharmaceutical therapy - Google Patents

Methods and compositions for oral pharmaceutical therapy Download PDF

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Publication number
AU2011262308B2
AU2011262308B2 AU2011262308A AU2011262308A AU2011262308B2 AU 2011262308 B2 AU2011262308 B2 AU 2011262308B2 AU 2011262308 A AU2011262308 A AU 2011262308A AU 2011262308 A AU2011262308 A AU 2011262308A AU 2011262308 B2 AU2011262308 B2 AU 2011262308B2
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AU
Australia
Prior art keywords
cancer
agent
composition
subject
taurolidine
Prior art date
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Active
Application number
AU2011262308A
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English (en)
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AU2011262308A1 (en
Inventor
Peter Geistlich
Rolf W. Pfirrmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Geistlich Pharma AG
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Geistlich Pharma AG
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Filing date
Publication date
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Publication of AU2011262308A1 publication Critical patent/AU2011262308A1/en
Application granted granted Critical
Publication of AU2011262308B2 publication Critical patent/AU2011262308B2/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Inorganic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2011262308A 2010-06-01 2011-06-01 Methods and compositions for oral pharmaceutical therapy Active AU2011262308B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US35018310P 2010-06-01 2010-06-01
US61/350,183 2010-06-01
US37031510P 2010-08-03 2010-08-03
US61/370,315 2010-08-03
PCT/IB2011/001539 WO2011151722A2 (en) 2010-06-01 2011-06-01 Methods and compositions for oral pharmaceutical therapy

Publications (2)

Publication Number Publication Date
AU2011262308A1 AU2011262308A1 (en) 2013-01-10
AU2011262308B2 true AU2011262308B2 (en) 2014-07-31

Family

ID=45067142

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011262308A Active AU2011262308B2 (en) 2010-06-01 2011-06-01 Methods and compositions for oral pharmaceutical therapy

Country Status (9)

Country Link
US (1) US9028866B2 (https=)
EP (1) EP2575783B1 (https=)
JP (2) JP5926243B2 (https=)
CN (1) CN103118669B (https=)
AU (1) AU2011262308B2 (https=)
BR (1) BR112012030641B8 (https=)
CA (1) CA2801309C (https=)
ES (1) ES2614878T3 (https=)
WO (1) WO2011151722A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104303076B (zh) * 2012-05-15 2017-11-21 飞利浦灯具控股公司 照明装置的控制
US11541061B2 (en) 2016-01-11 2023-01-03 Cormedix Inc. Neuroblastoma treatment with taurolidine hydrolysis products
US20190381060A1 (en) 2016-01-11 2019-12-19 Cormedix Inc. Taurolidine treatment for myc-expressing tumors in mammalian bodies
JP7614714B2 (ja) * 2016-01-11 2025-01-16 コーメディクス・インコーポレーテッド 神経芽細胞腫及びその他のがん治療のための治療ナノ粒子
US20190381058A1 (en) * 2016-01-11 2019-12-19 Cormedix Inc. Methods and compositions for treating neuroblastoma in a juvenile mammalian body
ES3006512T3 (en) 2017-11-17 2025-03-18 Evonik Operations Gmbh Process for preparing a coated hard shell capsule
KR20210050544A (ko) * 2018-08-28 2021-05-07 코르메딕스, 인코포레이티드 타우로리딘 가수분해 생성물을 이용한 신경모세포종 치료
EP3843747A4 (en) * 2018-08-31 2022-12-28 CorMedix Inc. TAUROLIDINE TREATMENT FOR MYC-EXPRESSING TUMORS IN MAMMALIAN BODY
US20220323452A1 (en) 2019-05-22 2022-10-13 Geistlich Pharma Ag Methods and compositions for inhibiting gapdh
WO2020234833A1 (en) 2019-05-22 2020-11-26 Geistlich Pharma Ag Method for treating, preventing, inhibiting or reducing cytokine release
CN111671758A (zh) * 2020-07-06 2020-09-18 长春迈灵生物工程有限公司 牛磺罗定在制备抗hiv病毒药物中的应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999034805A1 (en) * 1998-01-08 1999-07-15 Ed Geistlich Söhne Ag Für Chemische Industrie Use of antimicrobial agent such as taurolidine or taurultam in the manufacture of a medicament to treat a nosocomial microbial infection
WO2001039763A2 (en) * 1999-12-06 2001-06-07 Rhode Island Hospital, A Lifespan Partner Use of methylol-containing compounds for the manufacture of a medicament for the treatment of tumors
US6251896B1 (en) * 1999-03-24 2001-06-26 Carter-Wallace, Inc. Compositions and methods for the management of Crohn's disease
EP1116488A2 (en) * 2000-01-05 2001-07-18 Ed. Geistlich Söhne Ag Für Chemische Industrie Treatment of inflammatory Bowel disease
US20050053660A1 (en) * 2001-01-31 2005-03-10 Roehm Gmbh & Co. Kg Multi-particulate form of medicament, comprising at least two differently coated forms of pellet
US20060198886A1 (en) * 2005-03-01 2006-09-07 Jenkins Richard B Medicament having coated methenamine combined with acidifier

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210083A (en) 1986-07-17 1993-05-11 Ed. Geistlich Sohne A.G. Fur Chemische Industrie Pharmaceutical compositions
IE66933B1 (en) * 1990-01-15 1996-02-07 Elan Corp Plc Controlled absorption naproxen formulation for once-daily administration
US20030027818A1 (en) * 2001-04-03 2003-02-06 Redmond H. Paul Treatment of cancers
US6555534B1 (en) 1998-09-11 2003-04-29 Medpointe Healthcare Inc. Method and compositions for the control or eradication of Helicobacter pylori
US20020098164A1 (en) * 2000-10-27 2002-07-25 Redmond H. Paul Treatment of tumor metastases and cancer
US6593292B1 (en) * 1999-08-24 2003-07-15 Cellgate, Inc. Compositions and methods for enhancing drug delivery across and into epithelial tissues
US20040170617A1 (en) * 2000-06-05 2004-09-02 Finegold Sydney M. Method of treating diseases associated with abnormal gastrointestinal flora
US20030092707A1 (en) * 2001-10-19 2003-05-15 Redmond H. Paul Treatment of breast cancer
US9138408B2 (en) 2002-06-21 2015-09-22 L'oreal Use of taurine for treating alopecia
BRPI0617663A2 (pt) * 2005-10-21 2011-08-02 Panacea Biotec Ltd composições aperfeiçoadas para terapia de cáncer
ES2318628T3 (es) * 2006-07-25 2009-05-01 Claus Herdeis Preparacion de formulaciones antimicrobianas que comprenden 7-oxa-2-tia-1,5 diazabiciclo(3.3.1)-nonan-2,2-diona.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999034805A1 (en) * 1998-01-08 1999-07-15 Ed Geistlich Söhne Ag Für Chemische Industrie Use of antimicrobial agent such as taurolidine or taurultam in the manufacture of a medicament to treat a nosocomial microbial infection
US6251896B1 (en) * 1999-03-24 2001-06-26 Carter-Wallace, Inc. Compositions and methods for the management of Crohn's disease
WO2001039763A2 (en) * 1999-12-06 2001-06-07 Rhode Island Hospital, A Lifespan Partner Use of methylol-containing compounds for the manufacture of a medicament for the treatment of tumors
EP1116488A2 (en) * 2000-01-05 2001-07-18 Ed. Geistlich Söhne Ag Für Chemische Industrie Treatment of inflammatory Bowel disease
US20050053660A1 (en) * 2001-01-31 2005-03-10 Roehm Gmbh & Co. Kg Multi-particulate form of medicament, comprising at least two differently coated forms of pellet
US20060198886A1 (en) * 2005-03-01 2006-09-07 Jenkins Richard B Medicament having coated methenamine combined with acidifier

Also Published As

Publication number Publication date
CN103118669B (zh) 2016-01-13
CN103118669A (zh) 2013-05-22
BR112012030641B1 (pt) 2022-05-24
CA2801309C (en) 2018-07-17
WO2011151722A2 (en) 2011-12-08
JP5926243B2 (ja) 2016-05-25
BR112012030641A2 (pt) 2016-08-16
EP2575783A2 (en) 2013-04-10
BR112012030641B8 (pt) 2022-06-14
US20130089606A1 (en) 2013-04-11
EP2575783B1 (en) 2017-01-11
JP2016155826A (ja) 2016-09-01
CA2801309A1 (en) 2011-12-08
ES2614878T3 (es) 2017-06-02
HK1183228A1 (zh) 2013-12-20
WO2011151722A3 (en) 2012-05-24
US9028866B2 (en) 2015-05-12
AU2011262308A1 (en) 2013-01-10
JP2013527224A (ja) 2013-06-27

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