EP3843747A4 - Taurolidine treatment for myc-expressing tumors in mammalian bodies - Google Patents

Taurolidine treatment for myc-expressing tumors in mammalian bodies Download PDF

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Publication number
EP3843747A4
EP3843747A4 EP19854097.3A EP19854097A EP3843747A4 EP 3843747 A4 EP3843747 A4 EP 3843747A4 EP 19854097 A EP19854097 A EP 19854097A EP 3843747 A4 EP3843747 A4 EP 3843747A4
Authority
EP
European Patent Office
Prior art keywords
myc
expressing tumors
mammalian bodies
taurolidine treatment
taurolidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19854097.3A
Other languages
German (de)
French (fr)
Other versions
EP3843747A1 (en
Inventor
Bruce Reidenberg
Robert Diluccio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cormedix Inc
Original Assignee
Cormedix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cormedix Inc filed Critical Cormedix Inc
Publication of EP3843747A1 publication Critical patent/EP3843747A1/en
Publication of EP3843747A4 publication Critical patent/EP3843747A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP19854097.3A 2018-08-31 2019-09-03 Taurolidine treatment for myc-expressing tumors in mammalian bodies Pending EP3843747A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862725650P 2018-08-31 2018-08-31
PCT/US2019/049266 WO2020047530A1 (en) 2018-08-31 2019-09-03 Taurolidine treatment for myc-expressing tumors in mammalian bodies

Publications (2)

Publication Number Publication Date
EP3843747A1 EP3843747A1 (en) 2021-07-07
EP3843747A4 true EP3843747A4 (en) 2022-12-28

Family

ID=69643283

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19854097.3A Pending EP3843747A4 (en) 2018-08-31 2019-09-03 Taurolidine treatment for myc-expressing tumors in mammalian bodies

Country Status (7)

Country Link
EP (1) EP3843747A4 (en)
JP (1) JP2021535167A (en)
KR (1) KR20210054544A (en)
CN (1) CN113226325A (en)
AU (1) AU2019331913A1 (en)
CA (1) CA3111100A1 (en)
WO (1) WO2020047530A1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001039762A2 (en) * 1999-12-06 2001-06-07 Rhode Island Hospital, A Lifespan Partner Use of taurolidine or taurultam for the manufacture of a medicament for the treatment of tumors of the central nervous system
US20040176360A1 (en) * 1999-12-06 2004-09-09 Paul Calabresi Use of taurolidine to treat tumors
WO2007077528A1 (en) * 2006-01-06 2007-07-12 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Irradiated compositions and treatment of cancers with radiation in combination with taurolidine and/or taurultam
US20080171738A1 (en) * 2001-04-03 2008-07-17 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Treatment of Breast Cancer
WO2017158570A1 (en) * 2016-03-18 2017-09-21 Geistlich Pharma Ag Method of treating triple negative breast cancer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9005856D0 (en) * 1990-03-15 1990-05-09 Geistlich Soehne Ag Compositions
US20030027818A1 (en) * 2001-04-03 2003-02-06 Redmond H. Paul Treatment of cancers
US7151099B2 (en) * 1998-07-31 2006-12-19 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Use of taurolidine and/or taurultam for treatment of abdominal cancer and/or for the prevention of metastases
GB9716219D0 (en) * 1997-07-31 1997-10-08 Geistlich Soehne Ag Prevention of metastases
US20030092707A1 (en) * 2001-10-19 2003-05-15 Redmond H. Paul Treatment of breast cancer
JP5043294B2 (en) * 2003-09-29 2012-10-10 エー・デー・ガイストリヒ・ゾーネ・アクチェンゲゼルシャフト・フュール・ヒェーミシェ・インダストリー How to treat mesothelioma
US7964571B2 (en) * 2004-12-09 2011-06-21 Egen, Inc. Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases
WO2007020509A1 (en) * 2005-08-15 2007-02-22 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Combination of methylol transfer agents with tumour-inhibiting proteins or peptides and the use thereof for the treatment of cancer or tumor growth
JP5926243B2 (en) * 2010-06-01 2016-05-25 ガイストリヒ・ファーマ・アクチェンゲゼルシャフトＧｅｉｓｔｌｉｃｈ Ｐｈａｒｍａ Ａｇ Methods and compositions for oral drug therapy
CN108778339A (en) * 2016-01-11 2018-11-09 科医公司 Therapeutic nano particle for treating neuroblastoma and other cancers

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001039762A2 (en) * 1999-12-06 2001-06-07 Rhode Island Hospital, A Lifespan Partner Use of taurolidine or taurultam for the manufacture of a medicament for the treatment of tumors of the central nervous system
US20040176360A1 (en) * 1999-12-06 2004-09-09 Paul Calabresi Use of taurolidine to treat tumors
US20080171738A1 (en) * 2001-04-03 2008-07-17 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Treatment of Breast Cancer
WO2007077528A1 (en) * 2006-01-06 2007-07-12 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Irradiated compositions and treatment of cancers with radiation in combination with taurolidine and/or taurultam
WO2017158570A1 (en) * 2016-03-18 2017-09-21 Geistlich Pharma Ag Method of treating triple negative breast cancer

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ANGERER JÜRGEN ET AL: "Opinion on methylene glycol", 26 June 2012 (2012-06-26), pages 1 - 14, XP055982131, Retrieved from the Internet <URL:chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_097.pdf> [retrieved on 20221116] *
ANONYMOUS: "Cormedix Inc. announces agreement with nanoproteagen for its proprietary nanoparticle technology, Nanopro TM, in combination with CRMD-005 for pediatric neuroblastoma", INTERNET CITATION, 11 May 2016 (2016-05-11), XP002792142, Retrieved from the Internet <URL:http://www.cormedix.com/cormedix-inc-announces-agreement-with-nanoproteagen-for-its-proprietary-nanoparticle-technology-nanopro-in-combination-with-crmd-005-for-pediatric-neuroblastoma-2/> [retrieved on 20190617] *
JONES D S ET AL: "A study of the stability of taurolidine in plasma and protein-free serum", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER, NL, vol. 64, no. 2-3, 30 October 1990 (1990-10-30), pages R1 - R4, XP023736496, ISSN: 0378-5173, [retrieved on 19901030], DOI: 10.1016/0378-5173(90)90278-C *
KEVIN MARLEY ET AL: "Pharmacokinetic study and evaluation of the safety of taurolidine for dogs with osteosarcoma", JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, BIOMED CENTRAL LTD, LONDON UK, vol. 32, no. 1, 11 October 2013 (2013-10-11), pages 74, XP021165358, ISSN: 1756-9966, DOI: 10.1186/1756-9966-32-74 *
LUO JUHUA ET AL: "Association between Six Environmental Chemicals and Lung Cancer Incidence in the United States", JOURNAL OF ENVIRONMENTAL AND PUBLIC HEALTH, vol. 2011, no. 9, 1 January 2011 (2011-01-01), pages 1 - 9, XP055982102, ISSN: 1687-9805, Retrieved from the Internet <URL:https://downloads.hindawi.com/journals/jeph/2011/463701.pdf> DOI: 10.1155/2011/463701 *
MÖHLER HANS ET AL: "Redox-directed cancer therapeutics: Taurolidine and Piperlongumine as broadly effective antineoplastic agents (Review)", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 45, no. 4, 1 October 2014 (2014-10-01), GR, pages 1329 - 1336, XP055945228, ISSN: 1019-6439, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151817/pdf/ijo-45-04-1329.pdf> DOI: 10.3892/ijo.2014.2566 *
See also references of WO2020047530A1 *
STENDEL RUEDIGER ET AL: "Pharmacokinetics of Taurolidine following Repeated Intravenous Infusions Measured by HPLC-ESI-MS/MS of the Derivatives Taurultame and Taurinamide in Glioblastoma Patients :", CLINICAL PHARMACOKINETICS., vol. 46, no. 6, 1 January 2007 (2007-01-01), NZ, pages 513 - 524, XP055945305, ISSN: 0312-5963, Retrieved from the Internet <URL:http://dx.doi.org/10.2165/00003088-200746060-00005> DOI: 10.2165/00003088-200746060-00005 *

Also Published As

Publication number Publication date
CN113226325A (en) 2021-08-06
AU2019331913A1 (en) 2021-04-29
WO2020047530A1 (en) 2020-03-05
CA3111100A1 (en) 2020-03-05
EP3843747A1 (en) 2021-07-07
KR20210054544A (en) 2021-05-13
JP2021535167A (en) 2021-12-16

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RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 9/50 20060101ALI20220727BHEP

Ipc: A61K 38/19 20060101ALI20220727BHEP

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