AU2010356747B2 - Compound for inhibiting type 5 phosphodiesterase and preparation method thereof - Google Patents

Compound for inhibiting type 5 phosphodiesterase and preparation method thereof Download PDF

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Publication number
AU2010356747B2
AU2010356747B2 AU2010356747A AU2010356747A AU2010356747B2 AU 2010356747 B2 AU2010356747 B2 AU 2010356747B2 AU 2010356747 A AU2010356747 A AU 2010356747A AU 2010356747 A AU2010356747 A AU 2010356747A AU 2010356747 B2 AU2010356747 B2 AU 2010356747B2
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AU
Australia
Prior art keywords
compound
zth
formula
methyl
pyrazolo
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Ceased
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AU2010356747A
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English (en)
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AU2010356747A1 (en
Inventor
Nan Zhang
Rong Zhong
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SUZHOU MAIDIXIAN PHARMACEUTICAL Inc
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SUZHOU MAIDIXIAN PHARMACEUTICAL Inc
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Publication of AU2010356747A1 publication Critical patent/AU2010356747A1/en
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Publication of AU2010356747B2 publication Critical patent/AU2010356747B2/en
Ceased legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/265—Citric acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2010356747A 2010-07-02 2010-07-30 Compound for inhibiting type 5 phosphodiesterase and preparation method thereof Ceased AU2010356747B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2010102216587A CN101891747B (zh) 2010-07-02 2010-07-02 抑制5型磷酸二酯酶的化合物及制备方法
CN201010221658.7 2010-07-02
PCT/CN2010/075587 WO2012000212A1 (zh) 2010-07-02 2010-07-30 抑制5型磷酸二酯酶的化合物及制备方法

Publications (2)

Publication Number Publication Date
AU2010356747A1 AU2010356747A1 (en) 2012-06-07
AU2010356747B2 true AU2010356747B2 (en) 2014-10-30

Family

ID=43101120

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010356747A Ceased AU2010356747B2 (en) 2010-07-02 2010-07-30 Compound for inhibiting type 5 phosphodiesterase and preparation method thereof

Country Status (10)

Country Link
US (1) US8859565B2 (ko)
EP (1) EP2589601B1 (ko)
JP (1) JP5715247B2 (ko)
KR (1) KR20130044314A (ko)
CN (1) CN101891747B (ko)
AU (1) AU2010356747B2 (ko)
BR (1) BR112013000042A2 (ko)
CA (1) CA2803660C (ko)
RU (1) RU2547465C2 (ko)
WO (1) WO2012000212A1 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3099689B1 (en) * 2014-01-30 2022-01-26 Council of Scientific and Industrial Research Pyrazolopyrimidinones for the treatment of impotence and process for the preparation thereof
CN113493459B (zh) * 2020-04-07 2022-12-13 广州白云山医药集团股份有限公司白云山制药总厂 Pde5抑制剂化合物及其制备方法和应用
CN113461694A (zh) * 2021-08-05 2021-10-01 广东西捷药业有限公司 一种伐地那非类似物及其合成方法和应用
CN114163493B (zh) * 2021-11-18 2023-09-15 浙大宁波理工学院 一种可作为5型磷酸二酯酶抑制剂的多肽及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1517349A (zh) * 2003-01-16 2004-08-04 刘宝顺 两种治疗阳痿的新化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9301192D0 (en) * 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
ATE264861T1 (de) * 1998-09-04 2004-05-15 Ortho Mcneil Pharm Inc 5-heterozyklyl-pyrazolo(4,3-d)pyrimidin-7-one für die behandlung von männlichen erectilen dysfunktionen
CN1094492C (zh) * 1999-06-21 2002-11-20 杭州神鹰医药化工有限公司 西地那非的制备方法
CN1127506C (zh) * 2001-06-29 2003-11-12 刘宝顺 一种治疗阳痿的新化合物
US20060205733A1 (en) * 2004-08-26 2006-09-14 Encysive Pharmaceuticals Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1517349A (zh) * 2003-01-16 2004-08-04 刘宝顺 两种治疗阳痿的新化合物

Also Published As

Publication number Publication date
EP2589601A4 (en) 2013-11-13
RU2012155786A (ru) 2014-08-10
CN101891747A (zh) 2010-11-24
CN101891747B (zh) 2012-04-25
CA2803660A1 (en) 2012-01-05
BR112013000042A2 (pt) 2018-08-28
EP2589601A1 (en) 2013-05-08
CA2803660C (en) 2016-10-18
KR20130044314A (ko) 2013-05-02
RU2547465C2 (ru) 2015-04-10
US8859565B2 (en) 2014-10-14
WO2012000212A1 (zh) 2012-01-05
EP2589601B1 (en) 2015-09-09
JP5715247B2 (ja) 2015-05-07
JP2013529651A (ja) 2013-07-22
US20130116265A1 (en) 2013-05-09
AU2010356747A1 (en) 2012-06-07

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