AU2010322478B2 - Benzoimidazole compounds and uses thereof - Google Patents

Benzoimidazole compounds and uses thereof Download PDF

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Publication number
AU2010322478B2
AU2010322478B2 AU2010322478A AU2010322478A AU2010322478B2 AU 2010322478 B2 AU2010322478 B2 AU 2010322478B2 AU 2010322478 A AU2010322478 A AU 2010322478A AU 2010322478 A AU2010322478 A AU 2010322478A AU 2010322478 B2 AU2010322478 B2 AU 2010322478B2
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AU
Australia
Prior art keywords
compound
salt
formula
animal
methyl
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Active
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AU2010322478A
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English (en)
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AU2010322478A1 (en
Inventor
Louis-David Cantin
Xuehong Luo
Miroslaw Jerzy Tomaszewski
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GlaxoSmithKline Intellectual Property No 3 Ltd
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GlaxoSmithKline Intellectual Property No 3 Ltd
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Publication of AU2010322478A1 publication Critical patent/AU2010322478A1/en
Assigned to NEOMED INSTITUTE reassignment NEOMED INSTITUTE Request for Assignment Assignors: ASTRAZENECA AB
Application granted granted Critical
Publication of AU2010322478B2 publication Critical patent/AU2010322478B2/en
Assigned to BELLUS HEALTH COUGH INC. reassignment BELLUS HEALTH COUGH INC. Request for Assignment Assignors: NEOMED INSTITUTE
Assigned to GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 3) LIMITED reassignment GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 3) LIMITED Request for Assignment Assignors: BELLUS HEALTH COUGH INC.
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2010322478A 2009-11-18 2010-11-17 Benzoimidazole compounds and uses thereof Active AU2010322478B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26226309P 2009-11-18 2009-11-18
US61/262,263 2009-11-18
PCT/SE2010/051269 WO2011062550A1 (en) 2009-11-18 2010-11-17 Benzoimidazole compounds and uses thereof

Publications (2)

Publication Number Publication Date
AU2010322478A1 AU2010322478A1 (en) 2012-05-31
AU2010322478B2 true AU2010322478B2 (en) 2013-11-14

Family

ID=44059844

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010322478A Active AU2010322478B2 (en) 2009-11-18 2010-11-17 Benzoimidazole compounds and uses thereof

Country Status (16)

Country Link
US (1) US8530467B2 (https=)
EP (1) EP2501697B1 (https=)
JP (1) JP5657018B2 (https=)
KR (1) KR20120113709A (https=)
CN (1) CN102741245B (https=)
AR (1) AR079050A1 (https=)
AU (1) AU2010322478B2 (https=)
BR (1) BR112012011518B8 (https=)
CA (1) CA2777746C (https=)
ES (1) ES2442797T3 (https=)
IN (1) IN2012DN03391A (https=)
MX (1) MX2012005329A (https=)
RU (1) RU2542582C2 (https=)
TW (1) TW201121957A (https=)
UY (1) UY33037A (https=)
WO (1) WO2011062550A1 (https=)

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WO2012158117A1 (en) * 2011-05-17 2012-11-22 Astrazeneca Ab Combination therapies for treating pain
US9598409B2 (en) * 2013-01-31 2017-03-21 Neomed Institute Imidazopyridine compounds and uses thereof
CN105992761A (zh) * 2013-12-20 2016-10-05 盐野义制药株式会社 具有血小板生成素受体激动作用的光学活性的化合物及其中间体的制备方法
US10195198B2 (en) 2014-07-03 2019-02-05 Afferent Pharmaceuticals, Inc. Methods and compositions for treating diseases and conditions
US10111883B1 (en) * 2017-09-18 2018-10-30 Bellus Health Cough Inc. Selective P2X3 modulators
CN108904507A (zh) * 2018-02-11 2018-11-30 赖英杰 P2x3受体调节剂苯并咪唑化合物在制备抗呼吸疾病药物中的应用
WO2020135771A1 (zh) * 2018-12-29 2020-07-02 武汉朗来科技发展有限公司 杂环类化合物、中间体、其制备方法及应用
AU2020228760A1 (en) 2019-02-25 2021-09-23 Glaxosmithkline Intellectual Property (No. 3) Limited Treatment with P2X3 modulators
JP2023513373A (ja) * 2020-02-14 2023-03-30 べルス・ヘルス・コフ・インコーポレーテッド Ｐ２ｘ３修飾薬
EP4198034A4 (en) * 2020-08-13 2024-01-17 Tuojie Biotech (Shanghai) Co., Ltd. BENZIMIDAZOLE DERIVATIVES, PRODUCTION PROCESS THEREOF AND MEDICAL USE THEREOF
TW202227458A (zh) * 2020-12-04 2022-07-16 大陸商上海拓界生物醫藥科技有限公司 含有稠合三環的化合物及其醫藥用途
CN114478508A (zh) * 2021-12-31 2022-05-13 淮北师范大学 一种苯并咪唑化合物的结晶形式
WO2023151658A1 (zh) * 2022-02-11 2023-08-17 江苏恒瑞医药股份有限公司 一种p2x3受体拮抗剂的可药用盐及其制备方法
WO2023151660A1 (zh) * 2022-02-11 2023-08-17 江苏恒瑞医药股份有限公司 一种p2x3受体拮抗剂的结晶形式及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
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US20060264490A1 (en) * 2004-09-24 2006-11-23 Astrazeneca Ab Compounds, Compositions Containing Them, Preparation Thereof and Uses Thereof I
WO2008108958A2 (en) * 2007-03-02 2008-09-12 Schering Corporation Benzimidazole derivatives and methods of use thereof
WO2009058298A1 (en) * 2007-10-31 2009-05-07 Merck & Co., Inc. P2x3, receptor antagonists for treatment of pain

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US6026A (en) * 1849-01-09 Cast-iron car-wheel
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
BR9707495A (pt) 1996-02-13 1999-07-27 Zeneca Ltd Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente
US6291455B1 (en) 1996-03-05 2001-09-18 Zeneca Limited 4-anilinoquinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
SK288365B6 (sk) 1999-02-10 2016-07-01 Astrazeneca Ab Medziprodukty pre chinazolínové deriváty ako inhibítory angiogenézy
CN100415723C (zh) * 2000-01-17 2008-09-03 帝人株式会社 苯并咪唑衍生物
NZ522074A (en) 2000-05-31 2004-06-25 Astrazeneca Ab Indole derivatives with vascular damaging activity
UA73993C2 (uk) 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
IL153484A0 (en) 2000-07-07 2003-07-06 Angiogene Pharm Ltd Colchinol derivatives as angiogenesis inhibitors
CN1255392C (zh) 2000-07-07 2006-05-10 安吉奥金尼药品有限公司 作为血管生成抑制剂的秋水仙醇衍生物
US20090099195A1 (en) 2007-05-08 2009-04-16 Astrazeneca Ab Therapeutic Compounds 570

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060264490A1 (en) * 2004-09-24 2006-11-23 Astrazeneca Ab Compounds, Compositions Containing Them, Preparation Thereof and Uses Thereof I
WO2008108958A2 (en) * 2007-03-02 2008-09-12 Schering Corporation Benzimidazole derivatives and methods of use thereof
WO2009058298A1 (en) * 2007-10-31 2009-05-07 Merck & Co., Inc. P2x3, receptor antagonists for treatment of pain

Also Published As

Publication number Publication date
ES2442797T3 (es) 2014-02-13
EP2501697A4 (en) 2013-04-24
EP2501697A1 (en) 2012-09-26
AR079050A1 (es) 2011-12-21
UY33037A (es) 2011-06-30
CN102741245B (zh) 2014-11-05
EP2501697B1 (en) 2013-10-23
RU2012124268A (ru) 2013-12-27
CA2777746C (en) 2019-05-14
RU2542582C2 (ru) 2015-02-20
US20120289504A1 (en) 2012-11-15
BR112012011518B1 (pt) 2020-03-10
CN102741245A (zh) 2012-10-17
MX2012005329A (es) 2012-05-29
IN2012DN03391A (https=) 2015-10-23
WO2011062550A1 (en) 2011-05-26
JP5657018B2 (ja) 2015-01-21
BR112012011518A2 (pt) 2016-06-28
US8530467B2 (en) 2013-09-10
KR20120113709A (ko) 2012-10-15
AU2010322478A1 (en) 2012-05-31
CA2777746A1 (en) 2011-05-26
BR112012011518B8 (pt) 2023-01-10
JP2013511517A (ja) 2013-04-04
TW201121957A (en) 2011-07-01

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Owner name: NEOMED INSTITUTE

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Owner name: BELLUS HEALTH COUGH INC.

Free format text: FORMER OWNER(S): NEOMED INSTITUTE

PC Assignment registered

Owner name: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 3) LIMITED

Free format text: FORMER OWNER(S): BELLUS HEALTH COUGH INC.