AU2010295464B2 - Use of opioid receptor antagonist for gastrointestinal tract disorders - Google Patents

Use of opioid receptor antagonist for gastrointestinal tract disorders Download PDF

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Publication number
AU2010295464B2
AU2010295464B2 AU2010295464A AU2010295464A AU2010295464B2 AU 2010295464 B2 AU2010295464 B2 AU 2010295464B2 AU 2010295464 A AU2010295464 A AU 2010295464A AU 2010295464 A AU2010295464 A AU 2010295464A AU 2010295464 B2 AU2010295464 B2 AU 2010295464B2
Authority
AU
Australia
Prior art keywords
compound
opioid
dose
day
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010295464A
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English (en)
Other versions
AU2010295464A1 (en
Inventor
Richard M. Woodward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme Ltd
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43216894&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2010295464(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp and Dohme Ltd, Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme Ltd
Publication of AU2010295464A1 publication Critical patent/AU2010295464A1/en
Application granted granted Critical
Publication of AU2010295464B2 publication Critical patent/AU2010295464B2/en
Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP & DOHME CORP. Request for Assignment Assignors: ADOLOR CORPORATION
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2010295464A 2009-09-18 2010-09-17 Use of opioid receptor antagonist for gastrointestinal tract disorders Ceased AU2010295464B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24361609P 2009-09-18 2009-09-18
US61/243,616 2009-09-18
PCT/US2010/049311 WO2011035142A1 (en) 2009-09-18 2010-09-17 Use of opioid receptor antagonist for gastrointestinal tract disorders

Publications (2)

Publication Number Publication Date
AU2010295464A1 AU2010295464A1 (en) 2012-04-12
AU2010295464B2 true AU2010295464B2 (en) 2015-11-26

Family

ID=43216894

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010295464A Ceased AU2010295464B2 (en) 2009-09-18 2010-09-17 Use of opioid receptor antagonist for gastrointestinal tract disorders

Country Status (19)

Country Link
US (1) US20110071163A1 (enExample)
EP (1) EP2477627B1 (enExample)
JP (1) JP5797655B2 (enExample)
KR (1) KR20120092592A (enExample)
CN (2) CN102695508A (enExample)
AU (1) AU2010295464B2 (enExample)
BR (1) BR112012006069A8 (enExample)
CA (1) CA2774021A1 (enExample)
CL (1) CL2012000676A1 (enExample)
CO (1) CO6531453A2 (enExample)
HK (1) HK1210959A1 (enExample)
IL (1) IL218679A0 (enExample)
MX (1) MX342548B (enExample)
NZ (1) NZ598783A (enExample)
PE (1) PE20120991A1 (enExample)
RU (1) RU2561873C2 (enExample)
TW (1) TW201118084A (enExample)
WO (1) WO2011035142A1 (enExample)
ZA (1) ZA201201954B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE027856T2 (en) * 2012-12-28 2016-11-28 Inst Medycyny Doswiadczalnej I Klinicznej Im Miroslawa Mossakowskiego Polskiej Akademii Nauk Peptidomimetics and their use
TW201808937A (zh) 2016-05-20 2018-03-16 艾斯提夫博士實驗股份有限公司 針對疼痛具有多模態活性的四氫哌喃和噻喃衍生物
CN106117190B (zh) * 2016-06-21 2019-03-29 山东川成医药股份有限公司 一种倍福普兰的合成方法

Citations (2)

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US6734188B1 (en) * 1999-11-01 2004-05-11 John Rhodes Composition for treatment of constipation and irritable bowel syndrome
US20060217372A1 (en) * 2002-09-19 2006-09-28 Maria-Jesus Blanco-Pillado Diaryl ethers as opioid receptor antagonist

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US5159081A (en) * 1991-03-29 1992-10-27 Eli Lilly And Company Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
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US5378448A (en) * 1994-06-07 1995-01-03 Lin; Hsing K. Process for removing selenium from sulfur
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US6734188B1 (en) * 1999-11-01 2004-05-11 John Rhodes Composition for treatment of constipation and irritable bowel syndrome
US20060217372A1 (en) * 2002-09-19 2006-09-28 Maria-Jesus Blanco-Pillado Diaryl ethers as opioid receptor antagonist

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Also Published As

Publication number Publication date
CN104958298A (zh) 2015-10-07
BR112012006069A8 (pt) 2017-10-10
NZ598783A (en) 2013-07-26
IL218679A0 (en) 2012-05-31
KR20120092592A (ko) 2012-08-21
PE20120991A1 (es) 2012-08-01
CN102695508A (zh) 2012-09-26
ZA201201954B (en) 2012-11-28
WO2011035142A1 (en) 2011-03-24
HK1210959A1 (en) 2016-05-13
US20110071163A1 (en) 2011-03-24
JP5797655B2 (ja) 2015-10-21
BR112012006069A2 (pt) 2016-03-29
MX2012003310A (es) 2012-07-17
RU2561873C2 (ru) 2015-09-10
MX342548B (es) 2016-10-04
AU2010295464A1 (en) 2012-04-12
EP2477627A1 (en) 2012-07-25
EP2477627B1 (en) 2018-08-15
JP2013505260A (ja) 2013-02-14
TW201118084A (en) 2011-06-01
RU2012115450A (ru) 2013-10-27
CO6531453A2 (es) 2012-09-28
CA2774021A1 (en) 2011-03-24
CL2012000676A1 (es) 2012-10-19

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Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: MERCK SHARP & DOHME CORP.

Free format text: FORMER APPLICANT(S): ADOLOR CORPORATION

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired