AU2010258931B2 - Methods for increasing thermogenic adipocytes - Google Patents

Methods for increasing thermogenic adipocytes Download PDF

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Publication number
AU2010258931B2
AU2010258931B2 AU2010258931A AU2010258931A AU2010258931B2 AU 2010258931 B2 AU2010258931 B2 AU 2010258931B2 AU 2010258931 A AU2010258931 A AU 2010258931A AU 2010258931 A AU2010258931 A AU 2010258931A AU 2010258931 B2 AU2010258931 B2 AU 2010258931B2
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AU
Australia
Prior art keywords
actriib
polypeptide
antagonist
activin
sequence
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Application number
AU2010258931A
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English (en)
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AU2010258931A1 (en
Inventor
John Knopf
Ravindra Kumar
Jasbir Seehra
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Acceleron Pharma Inc
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Acceleron Pharma Inc
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Publication of AU2010258931A1 publication Critical patent/AU2010258931A1/en
Application granted granted Critical
Publication of AU2010258931B2 publication Critical patent/AU2010258931B2/en
Priority to AU2015205918A priority Critical patent/AU2015205918B2/en
Priority to AU2017203994A priority patent/AU2017203994A1/en
Priority to AU2019203342A priority patent/AU2019203342A1/en
Priority to AU2021225201A priority patent/AU2021225201A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1796—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653—Adipocytes; Adipose tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
AU2010258931A 2009-06-08 2010-06-08 Methods for increasing thermogenic adipocytes Active AU2010258931B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2015205918A AU2015205918B2 (en) 2009-06-08 2015-07-23 Methods for increasing thermogenic adipocytes
AU2017203994A AU2017203994A1 (en) 2009-06-08 2017-06-14 Methods for increasing thermogenic adipocytes
AU2019203342A AU2019203342A1 (en) 2009-06-08 2019-05-13 Methods for increasing thermogenic adipocytes
AU2021225201A AU2021225201A1 (en) 2009-06-08 2021-09-02 Methods for increasing thermogenic adipocytes

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US26812809P 2009-06-08 2009-06-08
US61/268,128 2009-06-08
US27642209P 2009-09-10 2009-09-10
US61/276,422 2009-09-10
US28054509P 2009-11-03 2009-11-03
US61/280,545 2009-11-03
PCT/US2010/037779 WO2010144452A1 (en) 2009-06-08 2010-06-08 Methods for increasing thermogenic adipocytes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2015205918A Division AU2015205918B2 (en) 2009-06-08 2015-07-23 Methods for increasing thermogenic adipocytes

Publications (2)

Publication Number Publication Date
AU2010258931A1 AU2010258931A1 (en) 2012-01-19
AU2010258931B2 true AU2010258931B2 (en) 2015-04-23

Family

ID=43300906

Family Applications (5)

Application Number Title Priority Date Filing Date
AU2010258931A Active AU2010258931B2 (en) 2009-06-08 2010-06-08 Methods for increasing thermogenic adipocytes
AU2015205918A Active AU2015205918B2 (en) 2009-06-08 2015-07-23 Methods for increasing thermogenic adipocytes
AU2017203994A Abandoned AU2017203994A1 (en) 2009-06-08 2017-06-14 Methods for increasing thermogenic adipocytes
AU2019203342A Abandoned AU2019203342A1 (en) 2009-06-08 2019-05-13 Methods for increasing thermogenic adipocytes
AU2021225201A Abandoned AU2021225201A1 (en) 2009-06-08 2021-09-02 Methods for increasing thermogenic adipocytes

Family Applications After (4)

Application Number Title Priority Date Filing Date
AU2015205918A Active AU2015205918B2 (en) 2009-06-08 2015-07-23 Methods for increasing thermogenic adipocytes
AU2017203994A Abandoned AU2017203994A1 (en) 2009-06-08 2017-06-14 Methods for increasing thermogenic adipocytes
AU2019203342A Abandoned AU2019203342A1 (en) 2009-06-08 2019-05-13 Methods for increasing thermogenic adipocytes
AU2021225201A Abandoned AU2021225201A1 (en) 2009-06-08 2021-09-02 Methods for increasing thermogenic adipocytes

Country Status (12)

Country Link
US (6) US8178488B2 (enExample)
EP (3) EP2440576A4 (enExample)
JP (5) JP5912078B2 (enExample)
KR (1) KR20120049214A (enExample)
CN (2) CN102482339B (enExample)
AU (5) AU2010258931B2 (enExample)
BR (1) BRPI1010587A2 (enExample)
CA (1) CA2764890A1 (enExample)
CO (1) CO6480999A2 (enExample)
IL (1) IL216852A0 (enExample)
MX (3) MX355042B (enExample)
WO (1) WO2010144452A1 (enExample)

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