AU2010211438B2 - Truncated cystine-knot proteins - Google Patents

Truncated cystine-knot proteins Download PDF

Info

Publication number
AU2010211438B2
AU2010211438B2 AU2010211438A AU2010211438A AU2010211438B2 AU 2010211438 B2 AU2010211438 B2 AU 2010211438B2 AU 2010211438 A AU2010211438 A AU 2010211438A AU 2010211438 A AU2010211438 A AU 2010211438A AU 2010211438 B2 AU2010211438 B2 AU 2010211438B2
Authority
AU
Australia
Prior art keywords
amino acid
acid sequence
length
amino acids
cystine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010211438A
Other languages
English (en)
Other versions
AU2010211438A1 (en
Inventor
Arjan Willem Griffioen
Tilman Mathias Hackeng
Wouter Cornelis Puijk
Peter Timmerman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pepscan Systems BV
Universiteit Maastricht
Academisch Ziekenhuis Maastricht
Original Assignee
Pepscan Systems BV
Universiteit Maastricht
Academisch Ziekenhuis Maastricht
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pepscan Systems BV, Universiteit Maastricht, Academisch Ziekenhuis Maastricht filed Critical Pepscan Systems BV
Publication of AU2010211438A1 publication Critical patent/AU2010211438A1/en
Application granted granted Critical
Publication of AU2010211438B2 publication Critical patent/AU2010211438B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2010211438A 2009-02-06 2010-02-05 Truncated cystine-knot proteins Ceased AU2010211438B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09152305.0 2009-02-06
EP09152305 2009-02-06
PCT/NL2010/050053 WO2010090523A1 (en) 2009-02-06 2010-02-05 Truncated cystine-knot proteins

Publications (2)

Publication Number Publication Date
AU2010211438A1 AU2010211438A1 (en) 2011-09-01
AU2010211438B2 true AU2010211438B2 (en) 2016-04-14

Family

ID=40834444

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010211438A Ceased AU2010211438B2 (en) 2009-02-06 2010-02-05 Truncated cystine-knot proteins

Country Status (8)

Country Link
US (1) US8772236B2 (https=)
EP (1) EP2393832B1 (https=)
JP (2) JP2012517425A (https=)
AU (1) AU2010211438B2 (https=)
CA (1) CA2751445C (https=)
ES (1) ES2545614T3 (https=)
NZ (1) NZ594481A (https=)
WO (1) WO2010090523A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2393832B1 (en) 2009-02-06 2015-07-08 Pepscan Systems BV Truncated cystine-knot proteins
US11078248B2 (en) 2010-03-19 2021-08-03 Lifenet Health BMP peptides and methods of use
CA2794165A1 (en) 2010-03-24 2011-09-29 Lifenet Health Bmp-4 peptides & methods of use
UA112981C2 (uk) * 2011-04-11 2016-11-25 Елі Ліллі Енд Компані Варіант людського gdnf
US20150064163A1 (en) * 2011-09-02 2015-03-05 Lifenet Health BMP Peptides & Methods of Use
CN105085652B (zh) * 2014-05-16 2021-06-22 中国人民解放军军事医学科学院生物工程研究所 血小板衍生生长因子b突变体、其制备方法及用途
CU24637B1 (es) * 2019-12-24 2022-12-12 Ct Ingenieria Genetica Biotecnologia Polipéptidos que comprenden mutantes del vegf-a humano con re-arreglos de puentes disulfuro y composiciones que los contienen

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000037025A2 (en) * 1998-12-21 2000-06-29 Ludwig Institute For Cancer Research Antibodies to truncated vegf-d and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2070393A1 (en) 1989-10-18 1991-04-19 Charles M. Cohen Biosynthetic constructs of tgf-beta
CA2345024C (en) * 1998-10-07 2009-05-19 Stryker Corporation Modified tgf-.beta. superfamily proteins
US7105481B2 (en) * 1998-11-10 2006-09-12 Ludwig Institute For Cancer Research Method for stimulating connective tissue growth or wound healing
ATE556090T1 (de) 1998-11-10 2012-05-15 Ludwig Inst Cancer Res Verkürzter, von blutplättchen abstammender wachstumsfaktor d, dafür kodierendes dns und deren verwendung
US20040009535A1 (en) * 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
EP1125905A1 (en) 2000-02-16 2001-08-22 Pepscan Systems B.V. Segment synthesis
EP1197755A1 (en) 2000-10-11 2002-04-17 Pepscan Systems B.V. Identification of protein binding sites
EP1452868A2 (en) 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
AU2005250441A1 (en) * 2004-05-27 2005-12-15 Acceleron Pharma Inc. TGF derepressors and uses related thereto
JP2009544697A (ja) 2006-07-26 2009-12-17 ペプスキャン システムズ ベー.フェー. 免疫原性化合物及びタンパク質擬態物
GB0710457D0 (en) * 2007-05-31 2007-07-11 Ark Therapeutics Ltd Vegf Mutants
EP2393832B1 (en) 2009-02-06 2015-07-08 Pepscan Systems BV Truncated cystine-knot proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000037025A2 (en) * 1998-12-21 2000-06-29 Ludwig Institute For Cancer Research Antibodies to truncated vegf-d and uses thereof

Also Published As

Publication number Publication date
JP6215879B2 (ja) 2017-10-18
NZ594481A (en) 2012-09-28
US20120231000A1 (en) 2012-09-13
WO2010090523A1 (en) 2010-08-12
JP2012517425A (ja) 2012-08-02
CA2751445C (en) 2018-06-19
US8772236B2 (en) 2014-07-08
EP2393832A1 (en) 2011-12-14
JP2015193662A (ja) 2015-11-05
CA2751445A1 (en) 2010-08-12
EP2393832B1 (en) 2015-07-08
AU2010211438A1 (en) 2011-09-01
ES2545614T3 (es) 2015-09-14

Similar Documents

Publication Publication Date Title
JP6215879B2 (ja) 切断型シスチンノットタンパク質
KR102258864B1 (ko) 허혈성 손상 치료 및 예방용 조성물
JP2008534628A (ja) ペプチド誘導体の製造のための方法
EP2611825B1 (en) Solid phase synthesis of h(gly2)glp-2
JPH10512881A (ja) 成長ホルモン放出ホルモンの新規な非常に効力のあるアゴニスト
KR20250074694A (ko) 인크레틴 유사체의 제조 방법
JP2013505269A (ja) オキシトシン受容体アゴニスト
NO311362B1 (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive polypeptider
JP7821393B2 (ja) Npy2受容体アゴニスト
HRP970416A2 (en) Method for the synthesis of analogs of parathyroid hormone and parathyroid hormone related peptide
TW202116350A (zh) Kv1.3阻斷劑
JP5744844B2 (ja) 副甲状腺ホルモン(pth)受容体アゴニストとしての短鎖ペプチド
KR101417872B1 (ko) 59번 위치에 아미노산 치환을 포함하는 인슐린 유사 성장 인자-1(igf-1)의 유사체
US5182261A (en) Modified transforming growth factor alpha oligopeptides and pharmaceutical compositions thereof
CA2192787A1 (en) Pth or pthrp antagonists
TWI796339B (zh) 一種肽類化合物、其應用及含其的組合物
CN114751962B (zh) 订书肽、其制备方法及其制药用途
TAM et al. Mapping the receptor‐recognition site of human transforming growth factor‐α
JP2010150253A (ja) 肝癌を治療するための薬剤
MXPA04009479A (es) Peptidos vegf y su uso.
CN114450294A (zh) 具有mmp2抑制作用的多肽
KR20190080860A (ko) 상처 치유 펩타이드
EA047394B1 (ru) Агонисты рецептора npy2
JPH07278191A (ja) 新規ペプチドもしくは蛋白質及びそれを探索する方法

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired