CA2751445C - Truncated cystine-knot proteins - Google Patents

Truncated cystine-knot proteins Download PDF

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Publication number
CA2751445C
CA2751445C CA2751445A CA2751445A CA2751445C CA 2751445 C CA2751445 C CA 2751445C CA 2751445 A CA2751445 A CA 2751445A CA 2751445 A CA2751445 A CA 2751445A CA 2751445 C CA2751445 C CA 2751445C
Authority
CA
Canada
Prior art keywords
amino acid
acid sequence
cystine
length
growth factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2751445A
Other languages
English (en)
French (fr)
Other versions
CA2751445A1 (en
Inventor
Peter Timmerman
Wouter Cornelis Puijk
Tilman Mathias Hackeng
Arjan Willem Griffioen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pepscan Systems BV
Universiteit Maastricht
Academisch Ziekenhuis Maastricht
Original Assignee
Pepscan Systems BV
Universiteit Maastricht
Academisch Ziekenhuis Maastricht
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pepscan Systems BV, Universiteit Maastricht, Academisch Ziekenhuis Maastricht filed Critical Pepscan Systems BV
Publication of CA2751445A1 publication Critical patent/CA2751445A1/en
Application granted granted Critical
Publication of CA2751445C publication Critical patent/CA2751445C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2751445A 2009-02-06 2010-02-05 Truncated cystine-knot proteins Expired - Fee Related CA2751445C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09152305 2009-02-06
EP09152305.0 2009-02-06
PCT/NL2010/050053 WO2010090523A1 (en) 2009-02-06 2010-02-05 Truncated cystine-knot proteins

Publications (2)

Publication Number Publication Date
CA2751445A1 CA2751445A1 (en) 2010-08-12
CA2751445C true CA2751445C (en) 2018-06-19

Family

ID=40834444

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2751445A Expired - Fee Related CA2751445C (en) 2009-02-06 2010-02-05 Truncated cystine-knot proteins

Country Status (8)

Country Link
US (1) US8772236B2 (https=)
EP (1) EP2393832B1 (https=)
JP (2) JP2012517425A (https=)
AU (1) AU2010211438B2 (https=)
CA (1) CA2751445C (https=)
ES (1) ES2545614T3 (https=)
NZ (1) NZ594481A (https=)
WO (1) WO2010090523A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2751445C (en) 2009-02-06 2018-06-19 Pepscan Systems B.V. Truncated cystine-knot proteins
US11078248B2 (en) 2010-03-19 2021-08-03 Lifenet Health BMP peptides and methods of use
JP5905446B2 (ja) 2010-03-24 2016-04-20 ライフネット ヘルス Ｂｍｐ−４ペプチドおよび使用方法
UA112981C2 (uk) * 2011-04-11 2016-11-25 Елі Ліллі Енд Компані Варіант людського gdnf
CA2847527A1 (en) 2011-09-02 2013-03-07 Lifenet Health Bmp peptides & methods of use
CN105085652B (zh) * 2014-05-16 2021-06-22 中国人民解放军军事医学科学院生物工程研究所 血小板衍生生长因子b突变体、其制备方法及用途
CU24637B1 (es) * 2019-12-24 2022-12-12 Ct Ingenieria Genetica Biotecnologia Polipéptidos que comprenden mutantes del vegf-a humano con re-arreglos de puentes disulfuro y composiciones que los contienen

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0496833A4 (en) * 1989-10-18 1992-12-02 Creative Biomolecules, Inc. Biosynthetic constructs of tgf--g(b)
JP3762222B2 (ja) 1998-10-07 2006-04-05 ストライカー・コーポレーション 改変型ＴＧＦ−βスーパーファミリータンパク質
US7105481B2 (en) * 1998-11-10 2006-09-12 Ludwig Institute For Cancer Research Method for stimulating connective tissue growth or wound healing
AU770899B2 (en) * 1998-11-10 2004-03-04 Licentia Ltd Platelet-derived growth factor D, DNA coding therefor, and uses thereof
US20040009535A1 (en) * 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
DE69930872T8 (de) * 1998-12-21 2007-05-03 Ludwig Institute For Cancer Research Antikörper gegen verkürzten vegf-d und deren verwendungen
EP1125905A1 (en) 2000-02-16 2001-08-22 Pepscan Systems B.V. Segment synthesis
EP1197755A1 (en) 2000-10-11 2002-04-17 Pepscan Systems B.V. Identification of protein binding sites
EP1452868A2 (en) 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
US20080119396A1 (en) * 2004-05-27 2008-05-22 Acceleron Pharma Inc. Tgf Derepressors and Uses Related Thereto
CA2659225A1 (en) 2006-07-26 2008-01-31 Pepscan Systems B.V. Immunogenic compounds and protein mimics
GB0710457D0 (en) * 2007-05-31 2007-07-11 Ark Therapeutics Ltd Vegf Mutants
CA2751445C (en) 2009-02-06 2018-06-19 Pepscan Systems B.V. Truncated cystine-knot proteins

Also Published As

Publication number Publication date
US8772236B2 (en) 2014-07-08
JP2015193662A (ja) 2015-11-05
CA2751445A1 (en) 2010-08-12
US20120231000A1 (en) 2012-09-13
WO2010090523A1 (en) 2010-08-12
EP2393832B1 (en) 2015-07-08
NZ594481A (en) 2012-09-28
AU2010211438B2 (en) 2016-04-14
JP6215879B2 (ja) 2017-10-18
AU2010211438A1 (en) 2011-09-01
JP2012517425A (ja) 2012-08-02
ES2545614T3 (es) 2015-09-14
EP2393832A1 (en) 2011-12-14

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20141006

MKLA Lapsed

Effective date: 20210205