AU2009283008A1 - Engineered anti-IL-13 antibodies, compositions, methods and uses - Google Patents
Engineered anti-IL-13 antibodies, compositions, methods and uses Download PDFInfo
- Publication number
- AU2009283008A1 AU2009283008A1 AU2009283008A AU2009283008A AU2009283008A1 AU 2009283008 A1 AU2009283008 A1 AU 2009283008A1 AU 2009283008 A AU2009283008 A AU 2009283008A AU 2009283008 A AU2009283008 A AU 2009283008A AU 2009283008 A1 AU2009283008 A1 AU 2009283008A1
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- Prior art keywords
- antibody
- seq
- human
- pos
- binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/5437—IL-13
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Addiction (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9047208P | 2008-08-20 | 2008-08-20 | |
| US61/090,472 | 2008-08-20 | ||
| US9723208P | 2008-09-16 | 2008-09-16 | |
| US61/097,232 | 2008-09-16 | ||
| PCT/US2009/053425 WO2010021874A2 (en) | 2008-08-20 | 2009-08-11 | Engineered anti-il-13 antibodies, compositions, methods and uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2009283008A1 true AU2009283008A1 (en) | 2010-02-25 |
Family
ID=41707613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2009283008A Abandoned AU2009283008A1 (en) | 2008-08-20 | 2009-08-11 | Engineered anti-IL-13 antibodies, compositions, methods and uses |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8399630B2 (https=) |
| EP (1) | EP2328615A2 (https=) |
| JP (2) | JP2012506695A (https=) |
| KR (1) | KR20110043786A (https=) |
| CN (1) | CN102264391A (https=) |
| AR (1) | AR073088A1 (https=) |
| AU (1) | AU2009283008A1 (https=) |
| BR (1) | BRPI0917370A2 (https=) |
| CA (1) | CA2734645A1 (https=) |
| CO (1) | CO6341573A2 (https=) |
| CR (1) | CR20110152A (https=) |
| EA (1) | EA201170357A1 (https=) |
| EC (1) | ECSP11010840A (https=) |
| IL (1) | IL211087A0 (https=) |
| MX (1) | MX2011001909A (https=) |
| NI (1) | NI201100040A (https=) |
| NZ (1) | NZ591098A (https=) |
| UY (1) | UY32060A (https=) |
| WO (1) | WO2010021874A2 (https=) |
| ZA (1) | ZA201102081B (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7306925B2 (en) | 2001-11-09 | 2007-12-11 | Vanderbilt University | Phage antibodies to radiation-inducible neoantigens |
| US7906102B2 (en) | 2001-10-03 | 2011-03-15 | Vanderbilt University | Ligands to radiation-induced molecules |
| EA201170357A1 (ru) * | 2008-08-20 | 2012-05-30 | Сентокор Орто Байотек Инк. | Инженерные антитела к il-13: композиции, способы и применение |
| GB0904214D0 (en) | 2009-03-11 | 2009-04-22 | Ucb Pharma Sa | Biological products |
| JP2013508287A (ja) * | 2009-10-14 | 2013-03-07 | ヤンセン バイオテツク,インコーポレーテツド | 抗体を親和性成熟する方法 |
| JOP20210044A1 (ar) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
| WO2013019730A1 (en) | 2011-07-29 | 2013-02-07 | The Washington University | Antibodies to tip-1 and grp78 |
| ES2702315T3 (es) | 2012-08-24 | 2019-02-28 | Univ California | Anticuerpos y vacunas para su uso en tratar cánceres ROR1 e inhibir metástasis |
| KR20150131208A (ko) | 2013-03-13 | 2015-11-24 | 이미지냅 인코포레이티드 | Cd8에의 항원 결합 구조체들 |
| EP3172222A4 (en) | 2014-07-24 | 2018-03-21 | Washington University | Compositions targeting radiation-induced molecules and methods of use thereof |
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| US8399630B2 (en) | 2013-03-19 |
| NZ591098A (en) | 2012-08-31 |
| KR20110043786A (ko) | 2011-04-27 |
| IL211087A0 (en) | 2011-04-28 |
| MX2011001909A (es) | 2011-03-21 |
| CN102264391A (zh) | 2011-11-30 |
| CR20110152A (es) | 2011-09-19 |
| AR073088A1 (es) | 2010-10-13 |
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| UY32060A (es) | 2010-02-26 |
| WO2010021874A2 (en) | 2010-02-25 |
| JP2012506695A (ja) | 2012-03-22 |
| US20100111959A1 (en) | 2010-05-06 |
| JP2013005805A (ja) | 2013-01-10 |
| NI201100040A (es) | 2011-09-03 |
| EP2328615A2 (en) | 2011-06-08 |
| WO2010021874A3 (en) | 2016-03-24 |
| BRPI0917370A2 (pt) | 2015-11-17 |
| CO6341573A2 (es) | 2011-11-21 |
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