CO6341573A2 - Anticuerpos anti-il-13 modificados, composiciones, métodos y usos - Google Patents

Anticuerpos anti-il-13 modificados, composiciones, métodos y usos

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Publication number
CO6341573A2
CO6341573A2 CO11019113A CO11019113A CO6341573A2 CO 6341573 A2 CO6341573 A2 CO 6341573A2 CO 11019113 A CO11019113 A CO 11019113A CO 11019113 A CO11019113 A CO 11019113A CO 6341573 A2 CO6341573 A2 CO 6341573A2
Authority
CO
Colombia
Prior art keywords
human
bind
receptor
alpha
monoclonal antibodies
Prior art date
Application number
CO11019113A
Other languages
English (en)
Inventor
Ronald V Swanson
Ellen Chi
Hong Mimi Zhou
Yiqing Feng
Alexey V Teplyakov
Jill M Carton
Karyn T Oneil
Jill Giles-Komar
Linus Hyun
Juan C Almagro
Wendy Cordier
Johan Fransson
Shanrong Zhao
Golapan Raghunathan
Original Assignee
Centocor Ortho Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Ortho Biotech Inc filed Critical Centocor Ortho Biotech Inc
Publication of CO6341573A2 publication Critical patent/CO6341573A2/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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Abstract

La presente invención proporciona anticuerpos monoclonales anti-IL13 capaces de bloquear la actividad biológica de la lL13, in vitro, in vivo, o in situ que incluye, pero no se limita a, inhibir variantes naturales o silvestres de la IL-13 humana que se unen al receptor IL13 alfa 1 humano, inhibir la IL-13 humana o variantes naturales de IL13 humana que se unen al receptor IL-13 alfa 2 humano, prevenir o suprimir la proliferación de células tumorales humanas dependientes de la IL-13 humana, inhibir la producción de IgE dependiente de la IL-13 humana, reducir la infiltración eosinofílica de los tejidos, y el anticuerpo tiene un sitio de unión específico en la IL-13 humana. Se proporcionan secuencias de aminoácidos de anticuerpos monoclonales anti-IL-13 ejemplares que pueden ser codificadas por ácidos nucleicos para la expresión en una célula huésped.
CO11019113A 2008-08-20 2011-02-17 Anticuerpos anti-il-13 modificados, composiciones, métodos y usos CO6341573A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9047208P 2008-08-20 2008-08-20
US9723208P 2008-09-16 2008-09-16

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CO6341573A2 true CO6341573A2 (es) 2011-11-21

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CO11019113A CO6341573A2 (es) 2008-08-20 2011-02-17 Anticuerpos anti-il-13 modificados, composiciones, métodos y usos

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US (2) US8399630B2 (es)
EP (1) EP2328615A2 (es)
JP (2) JP2012506695A (es)
KR (1) KR20110043786A (es)
CN (1) CN102264391A (es)
AR (1) AR073088A1 (es)
AU (1) AU2009283008A1 (es)
BR (1) BRPI0917370A2 (es)
CA (1) CA2734645A1 (es)
CO (1) CO6341573A2 (es)
CR (1) CR20110152A (es)
EA (1) EA201170357A1 (es)
EC (1) ECSP11010840A (es)
IL (1) IL211087A0 (es)
MX (1) MX2011001909A (es)
NI (1) NI201100040A (es)
NZ (1) NZ591098A (es)
UY (1) UY32060A (es)
WO (1) WO2010021874A2 (es)
ZA (1) ZA201102081B (es)

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BRPI0917370A2 (pt) * 2008-08-20 2015-11-17 Centocor Ortho Biotech Inc anticorpos anti-il-13 manipulados, composições, métodos e usos.
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