UY32060A - Anticuerpos anti-il-13 obtenidos mediante ingeniería, composiciones , métodos y usos - Google Patents

Anticuerpos anti-il-13 obtenidos mediante ingeniería, composiciones , métodos y usos

Info

Publication number
UY32060A
UY32060A UY0001032060A UY32060A UY32060A UY 32060 A UY32060 A UY 32060A UY 0001032060 A UY0001032060 A UY 0001032060A UY 32060 A UY32060 A UY 32060A UY 32060 A UY32060 A UY 32060A
Authority
UY
Uruguay
Prior art keywords
methods
engineering
compositions
antibodies obtained
antibodies
Prior art date
Application number
UY0001032060A
Other languages
English (en)
Inventor
Karyn T O Neil
Ronald V Swanson
Chi Ellen
Raghunathan Gopalan
Zhao Shanrong
Fransson Johan
Cordier Wendy
Juan C Almagro
Hyun Linus
Jill Giles-Komar
Jill M Carton
Hong Mimi Zhou
Alexey V Teplyakov
Original Assignee
Centocor Ortho Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Ortho Biotech Inc filed Critical Centocor Ortho Biotech Inc
Publication of UY32060A publication Critical patent/UY32060A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5437—IL-13

Abstract

La presente invención se refiere a anticuerpos inmunoespecíficos para la proteína interleucina-13 humana (IL-13) o fragmentos de la misma, así como también los métodos para preparar y usar los mismos, incluyendo indicaciones terapéuticas.
UY0001032060A 2008-08-20 2009-08-19 Anticuerpos anti-il-13 obtenidos mediante ingeniería, composiciones , métodos y usos UY32060A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9047208P 2008-08-20 2008-08-20
US9723208P 2008-09-16 2008-09-16

Publications (1)

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UY32060A true UY32060A (es) 2010-02-26

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UY0001032060A UY32060A (es) 2008-08-20 2009-08-19 Anticuerpos anti-il-13 obtenidos mediante ingeniería, composiciones , métodos y usos

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US (2) US8399630B2 (es)
EP (1) EP2328615A2 (es)
JP (2) JP2012506695A (es)
KR (1) KR20110043786A (es)
CN (1) CN102264391A (es)
AR (1) AR073088A1 (es)
AU (1) AU2009283008A1 (es)
BR (1) BRPI0917370A2 (es)
CA (1) CA2734645A1 (es)
CO (1) CO6341573A2 (es)
CR (1) CR20110152A (es)
EA (1) EA201170357A1 (es)
EC (1) ECSP11010840A (es)
IL (1) IL211087A0 (es)
MX (1) MX2011001909A (es)
NI (1) NI201100040A (es)
NZ (1) NZ591098A (es)
UY (1) UY32060A (es)
WO (1) WO2010021874A2 (es)
ZA (1) ZA201102081B (es)

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