AU2009275869B2 - Glutaminyl cyclase as a diagnostic / prognostic indicator for neurodegenerative diseases - Google Patents

Glutaminyl cyclase as a diagnostic / prognostic indicator for neurodegenerative diseases Download PDF

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AU2009275869B2
AU2009275869B2 AU2009275869A AU2009275869A AU2009275869B2 AU 2009275869 B2 AU2009275869 B2 AU 2009275869B2 AU 2009275869 A AU2009275869 A AU 2009275869A AU 2009275869 A AU2009275869 A AU 2009275869A AU 2009275869 B2 AU2009275869 B2 AU 2009275869B2
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biological sample
detected
isoform
normal control
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AU2009275869A1 (en
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Monique Bornack
Hans-Ulrich Demuth
Astrid Kehlen
Martin Kleinschmidt
Jens-Ulrich Rahfeld
Stephan Schilling
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Vivoryon Therapeutics NV
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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    • G01N2333/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1or LDCF-2
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    • G01N2333/91—Transferases (2.)
    • G01N2333/91045—Acyltransferases (2.3)
    • G01N2333/91074—Aminoacyltransferases (general) (2.3.2)
    • G01N2333/9108—Aminoacyltransferases (general) (2.3.2) with definite EC number (2.3.2.-)
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  • Life Sciences & Earth Sciences (AREA)
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  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2009275869A 2008-07-31 2009-07-31 Glutaminyl cyclase as a diagnostic / prognostic indicator for neurodegenerative diseases Active AU2009275869B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8515408P 2008-07-31 2008-07-31
US61/085,154 2008-07-31
PCT/EP2009/059951 WO2010012828A2 (en) 2008-07-31 2009-07-31 Glutaminyl cyclase as a diagnostic / prognostic indicator for neurodegenerative diseases

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AU2009275869A1 AU2009275869A1 (en) 2010-02-04
AU2009275869B2 true AU2009275869B2 (en) 2015-05-21

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US (3) US20100028918A1 (OSRAM)
EP (1) EP2329274B1 (OSRAM)
JP (1) JP5677297B2 (OSRAM)
KR (1) KR101682728B1 (OSRAM)
CN (2) CN103983787A (OSRAM)
AU (1) AU2009275869B2 (OSRAM)
BR (1) BRPI0916601B1 (OSRAM)
CA (1) CA2731933A1 (OSRAM)
EA (1) EA025107B1 (OSRAM)
IL (1) IL210266A (OSRAM)
MX (1) MX2011001093A (OSRAM)
NZ (1) NZ590658A (OSRAM)
SG (1) SG193148A1 (OSRAM)
WO (1) WO2010012828A2 (OSRAM)
ZA (1) ZA201100177B (OSRAM)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
JP2013519891A (ja) * 2010-02-18 2013-05-30 プロビオドルグ エージー ピログルタミン酸修飾ｍｃｐ−１を決定することにより炎症性疾患を診断する方法及びグルタミニルシクラーゼの阻害剤のスクリーニング方法
JP2014515364A (ja) 2011-05-27 2014-06-30 プロビオドルグ エージー 放射能標識グルタミニルシクラーゼ阻害剤
US20170363645A1 (en) 2014-12-19 2017-12-21 Probiodrug Ag Novel Method for the Detection of pGlu-Abeta Peptides
CN104946680A (zh) * 2015-06-11 2015-09-30 深圳大学 用于表达qc的重组载体及其制备方法、引物、基因工程菌
KR102362919B1 (ko) * 2016-07-08 2022-02-16 아지노모토 가부시키가이샤 경도 인지 장해 또는 알츠하이머형 인지증의 평가 방법
KR102858457B1 (ko) * 2023-06-07 2025-09-11 계명대학교 산학협력단 Ccl8 단백질 또는 이를 코딩하는 유전자를 유효성분으로 포함하는 퇴행성 뇌질환 진단용 바이오마커 조성물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008034891A2 (en) * 2006-09-21 2008-03-27 Probiodrug Ag Novel genes related to glutaminyl cyclase

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4374316B2 (ja) * 1993-01-25 2009-12-02 武田薬品工業株式会社 β−アミロイドまたはその誘導体に対する抗体およびその用途
JP3590468B2 (ja) * 1996-01-22 2004-11-17 財団法人 東京都医学研究機構 アルツハイマー病診断薬
EP1523499A2 (en) * 2002-07-24 2005-04-20 Innogenetics N.V. Fragments of beta-amyloid as targets for vaccination against alzheimer disease
US7732162B2 (en) * 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
MXPA05011861A (es) * 2003-05-05 2006-02-17 Probiodrug Ag Uso de efectores de ciclasas de glutamato y glutaminil.
CA2542419C (en) * 2003-10-15 2013-06-04 Probiodrug Ag Use of glutamyl cyclase inhibitors in the treatment of familial british dementia and familial danish dementia
US20060094064A1 (en) * 2003-11-19 2006-05-04 Sandip Ray Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids
KR101099206B1 (ko) * 2004-02-05 2011-12-27 프로비오드룩 아게 신규한 글루타미닐 시클라제 저해제
WO2006120104A1 (en) * 2005-04-11 2006-11-16 Probiodrug Ag Inhibitors of prolyl endopeptidase
ATE523788T1 (de) * 2006-06-08 2011-09-15 Fu Berlin ASSAY ZUR DIAGNOSE VON ALZHEIMER BASIEREND AUF DER BESTIMMUNG DES VERHÄLTNISSES VON SEKRETASE-Aß-SPALTPRODUKTEN
WO2008087197A1 (en) * 2007-01-19 2008-07-24 Probiodrug Ag In vivo screening models for treatment of alzheimer's disease and other qpct-related disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008034891A2 (en) * 2006-09-21 2008-03-27 Probiodrug Ag Novel genes related to glutaminyl cyclase

Also Published As

Publication number Publication date
US20150247180A1 (en) 2015-09-03
BRPI0916601B1 (pt) 2021-05-25
SG193148A1 (en) 2013-09-30
JP2011529571A (ja) 2011-12-08
NZ590658A (en) 2012-07-27
HK1155813A1 (en) 2012-05-25
ZA201100177B (en) 2012-02-29
IL210266A0 (en) 2011-03-31
US20170097365A1 (en) 2017-04-06
CN103983787A (zh) 2014-08-13
IL210266A (en) 2016-04-21
EP2329274A2 (en) 2011-06-08
KR20110049781A (ko) 2011-05-12
JP5677297B2 (ja) 2015-02-25
CA2731933A1 (en) 2010-02-04
US20100028918A1 (en) 2010-02-04
KR101682728B1 (ko) 2016-12-05
EA025107B1 (ru) 2016-11-30
CN102112880A (zh) 2011-06-29
WO2010012828A3 (en) 2010-05-06
MX2011001093A (es) 2011-03-15
WO2010012828A2 (en) 2010-02-04
EA201100253A1 (ru) 2011-10-31
EP2329274B1 (en) 2015-12-02
CN102112880B (zh) 2014-06-25
BRPI0916601A2 (pt) 2015-11-10
AU2009275869A1 (en) 2010-02-04

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