AU2009252758B2 - Monoclonal antibodies having homosubtype cross -neutralization properties against influenza a viruses subtype H1 - Google Patents

Monoclonal antibodies having homosubtype cross -neutralization properties against influenza a viruses subtype H1 Download PDF

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Publication number
AU2009252758B2
AU2009252758B2 AU2009252758A AU2009252758A AU2009252758B2 AU 2009252758 B2 AU2009252758 B2 AU 2009252758B2 AU 2009252758 A AU2009252758 A AU 2009252758A AU 2009252758 A AU2009252758 A AU 2009252758A AU 2009252758 B2 AU2009252758 B2 AU 2009252758B2
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Australia
Prior art keywords
influenza
virus
subtype
antibody
isolates
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AU2009252758A
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AU2009252758A1 (en
Inventor
Roberto Burioni
Massimo Clementi
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Pomona Ricerca SRL
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Pomona Ricerca SRL
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Publication of AU2009252758A1 publication Critical patent/AU2009252758A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2009252758A 2008-05-27 2009-05-27 Monoclonal antibodies having homosubtype cross -neutralization properties against influenza a viruses subtype H1 Ceased AU2009252758B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000398A ITTO20080398A1 (it) 2008-05-27 2008-05-27 Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1
ITTO2008A000398 2008-05-27
PCT/IB2009/052212 WO2009144667A1 (en) 2008-05-27 2009-05-27 Monoclonal antibodies having homosubtype cross -neutralization properties against influenza a viruses subtype h1

Publications (2)

Publication Number Publication Date
AU2009252758A1 AU2009252758A1 (en) 2009-12-03
AU2009252758B2 true AU2009252758B2 (en) 2014-07-31

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AU2009252758A Ceased AU2009252758B2 (en) 2008-05-27 2009-05-27 Monoclonal antibodies having homosubtype cross -neutralization properties against influenza a viruses subtype H1

Country Status (17)

Country Link
US (1) US9243054B2 (https=)
EP (1) EP2294084B2 (https=)
JP (1) JP5792060B2 (https=)
KR (1) KR101665146B1 (https=)
CN (1) CN102124028B (https=)
AU (1) AU2009252758B2 (https=)
BR (1) BRPI0912285A2 (https=)
CA (1) CA2725627C (https=)
EA (1) EA022855B1 (https=)
ES (1) ES2555486T5 (https=)
IL (1) IL209499A (https=)
IT (1) ITTO20080398A1 (https=)
MX (1) MX2010012974A (https=)
NZ (1) NZ590115A (https=)
SG (1) SG191610A1 (https=)
WO (1) WO2009144667A1 (https=)
ZA (1) ZA201009273B (https=)

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ITTO20080398A1 (it) 2008-05-27 2009-11-28 Pomona Biotechnologies Llc Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1
ITTO20080964A1 (it) 2008-12-22 2010-06-23 Natimab Therapeutics S R L Anticorpo monoclonale anti-hcv come medicamento per il trattamento terapeutico e la prevenzione di infezioni da hcv
IT1395961B1 (it) * 2009-06-01 2012-11-02 Pomona Biotechnologies Llc Anticorpi monoclonali come medicamento per il trattamento terapeutico e/o profilattico delle infezioni da virus influenzale a (h1n1) di origine suina (s-oiv)
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US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
SI3052192T1 (sl) 2013-10-02 2020-11-30 Medimmune, Llc Nevtralizarijoča protitelesa proti-influenci A in njihove uporabe
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EP3374390A1 (en) 2015-11-13 2018-09-19 Visterra, Inc. Compositions and methods for treating and preventing influenza
SG11201805001UA (en) 2016-01-13 2018-07-30 Medimmune Llc Method of treating influenza a
AU2017222564A1 (en) 2016-02-24 2018-09-06 Visterra, Inc. Formulations of antibody molecules to influenza virus
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PT3589730T (pt) 2017-02-28 2024-02-28 Univ Pennsylvania Vetor de vírus adenoassociado (aav) de clado f e suas utilizações
UY37620A (es) 2017-02-28 2018-08-31 Univ Pennsylvania Vacunas contra la gripe mediadas por aav novedosas
KR101972238B1 (ko) * 2017-11-22 2019-04-24 한국생명공학연구원 인플루엔자 a 바이러스 특이적 항체 또는 그의 항원 결합 단편
US11230593B2 (en) 2019-03-25 2022-01-25 Visterra, Inc. Compositions and methods for treating and preventing influenza
TW202237850A (zh) 2020-12-01 2022-10-01 賓州大學委員會 具有組織特異性靶向基序的新穎構成物及含有其之組成物
AU2022264509A1 (en) 2021-04-27 2023-12-14 Generation Bio Co. Non-viral dna vectors expressing therapeutic antibodies and uses thereof
CN119072330A (zh) 2022-03-14 2024-12-03 世代生物公司 异源初免加强疫苗组合物和使用方法
CN121175327A (zh) * 2023-05-23 2025-12-19 斯克里普斯研究学院 作为流感疫苗抗原的稳定的血凝素（ha）三聚体
CN121021682B (zh) * 2025-10-29 2026-02-03 山东第一医科大学(山东省医学科学院) 一种抗甲型h1n1亚型猪流感病毒的重组纳米抗体及其制备方法和应用

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Also Published As

Publication number Publication date
IL209499A (en) 2016-10-31
ES2555486T5 (es) 2019-02-15
NZ590115A (en) 2012-08-31
IL209499A0 (en) 2011-01-31
CN102124028B (zh) 2015-05-20
CN102124028A (zh) 2011-07-13
WO2009144667A1 (en) 2009-12-03
EP2294084B1 (en) 2015-09-09
ES2555486T3 (es) 2016-01-04
KR101665146B1 (ko) 2016-10-11
ZA201009273B (en) 2012-05-01
US20110076265A1 (en) 2011-03-31
ITTO20080398A1 (it) 2009-11-28
AU2009252758A1 (en) 2009-12-03
EP2294084A1 (en) 2011-03-16
CA2725627C (en) 2019-08-06
SG191610A1 (en) 2013-07-31
CA2725627A1 (en) 2009-12-03
BRPI0912285A2 (pt) 2015-10-20
EA201071365A1 (ru) 2011-08-30
JP5792060B2 (ja) 2015-10-07
EA022855B1 (ru) 2016-03-31
US9243054B2 (en) 2016-01-26
KR20110020865A (ko) 2011-03-03
MX2010012974A (es) 2011-01-21
JP2011524161A (ja) 2011-09-01
EP2294084B2 (en) 2018-09-05

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