AU2009243319B2 - Novel process for preparation of iopromide - Google Patents

Novel process for preparation of iopromide Download PDF

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Publication number
AU2009243319B2
AU2009243319B2 AU2009243319A AU2009243319A AU2009243319B2 AU 2009243319 B2 AU2009243319 B2 AU 2009243319B2 AU 2009243319 A AU2009243319 A AU 2009243319A AU 2009243319 A AU2009243319 A AU 2009243319A AU 2009243319 B2 AU2009243319 B2 AU 2009243319B2
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AU
Australia
Prior art keywords
formula
compound
oac
meo
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2009243319A
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English (en)
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AU2009243319A1 (en
Inventor
Soon Min Chung
Kook Sang Hwang
Goon Ho Joe
Bok Tae Kim
Byeong Cheol Kim
Chang Ki Kim
Ju Young Lee
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LG Chem Ltd
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LG Life Sciences Ltd
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Publication date
Application filed by LG Life Sciences Ltd filed Critical LG Life Sciences Ltd
Publication of AU2009243319A1 publication Critical patent/AU2009243319A1/en
Application granted granted Critical
Publication of AU2009243319B2 publication Critical patent/AU2009243319B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/68—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU2009243319A 2008-04-30 2009-04-17 Novel process for preparation of iopromide Ceased AU2009243319B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2008-0040521 2008-04-30
KR1020080040521A KR101098553B1 (ko) 2008-04-30 2008-04-30 이오프로마이드의 신규한 제조방법
PCT/KR2009/001996 WO2009134030A1 (fr) 2008-04-30 2009-04-17 Nouveau procédé de préparation de l’iopromide

Publications (2)

Publication Number Publication Date
AU2009243319A1 AU2009243319A1 (en) 2009-11-05
AU2009243319B2 true AU2009243319B2 (en) 2011-09-08

Family

ID=41255206

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009243319A Ceased AU2009243319B2 (en) 2008-04-30 2009-04-17 Novel process for preparation of iopromide

Country Status (10)

Country Link
US (1) US8420858B2 (fr)
EP (1) EP2271615A4 (fr)
JP (1) JP5156862B2 (fr)
KR (1) KR101098553B1 (fr)
CN (1) CN102015624B (fr)
AU (1) AU2009243319B2 (fr)
BR (1) BRPI0911531A2 (fr)
CA (1) CA2720752C (fr)
RU (1) RU2451667C1 (fr)
WO (1) WO2009134030A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1926459B1 (fr) 2005-09-19 2015-01-07 Histogenics Corporation Matrice support de cellules dont la densite des pores et la porosite sont definies specifiquement de maniere uniforme verticalement et organisees de maniere non aleatoire, et procede de preparation de celle-ci
KR100976097B1 (ko) * 2008-12-05 2010-08-16 주식회사 대웅제약 이오프로마이드의 ｚ 이성체를 선택적으로 결정화하는 방법
CN102351735B (zh) * 2011-07-21 2012-10-10 浙江司太立制药股份有限公司 一种碘普罗胺的制备方法
CN103570580B (zh) * 2012-08-08 2015-04-01 北京京卫信康医药科技发展有限公司 一种高纯度碘普罗胺的制备方法
CN102964269B (zh) * 2012-11-29 2015-01-28 浙江海昌药业有限公司 碘普罗胺的新制备方法
KR101520187B1 (ko) * 2013-10-25 2015-05-13 주식회사 대웅제약 이오프로마이드의 중간체의 제조방법
CN105001113B (zh) * 2014-04-18 2018-11-20 沈阳中海生物技术开发有限公司 一种碘普罗胺的制备方法
CN105017063B (zh) * 2014-04-18 2018-11-20 沈阳中海生物技术开发有限公司 5-氨基-2,4,6-三碘间苯二甲酸衍生物及其盐、水合物或溶剂化物
CN105017062B (zh) * 2014-04-18 2018-11-20 沈阳中海生物技术开发有限公司 制备碘普罗胺的新方法
CN103965074B (zh) * 2014-04-30 2016-10-05 淮海工学院 一种合成碘普罗胺的新方法
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
CN106316878B (zh) * 2015-06-15 2018-01-19 重庆常捷医药有限公司 一种碘美普尔杂质的制备方法
CN106366015B (zh) * 2015-07-22 2019-01-25 正大天晴药业集团股份有限公司 一种碘普罗胺的制备方法及其中间体
CN106366016B (zh) * 2015-07-22 2019-03-05 连云港润众制药有限公司 一种碘普罗胺的制备方法及其中间体
US10836710B2 (en) * 2016-12-05 2020-11-17 Bracco Imaging Spa Mechanochemical synthesis of radiographic agents intermediates
CN109134289B (zh) * 2017-06-16 2021-06-11 成都西岭源药业有限公司 一种造影剂中间体的合成方法及其应用
CN114436880B (zh) * 2020-11-03 2023-04-28 成都倍特药业股份有限公司 碘普罗胺中间体的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024757A1 (fr) * 1996-12-04 1998-06-11 Dibra S.P.A. Procede de preparation de derives de l'acide 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylique
US5824821A (en) * 1997-02-07 1998-10-20 Nycomed Imaging As Process for the preparation of iodinated contrast agents and intermediates therefor
KR20000061780A (ko) * 1999-03-31 2000-10-25 강재헌 이오프로마이드의 제조방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3457302A (en) * 1966-05-27 1969-07-22 Allied Chem Process for the preparation of tertiary amino acids
CH608189A5 (fr) * 1974-12-13 1978-12-29 Savac Ag
DE2909439A1 (de) * 1979-03-08 1980-09-18 Schering Ag Neue nichtionische roentgenkontrastmittel
US5075502A (en) * 1989-12-13 1991-12-24 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
IT1292037B1 (it) * 1997-05-30 1999-01-25 Bracco Spa Processo per la preparazione di 5-(acetil 62,3-diidrossipropil)- ammino)-n,n'-bis(2,3-diidrossipropil)-2,4,6-triiodo-1,3-benzen-

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024757A1 (fr) * 1996-12-04 1998-06-11 Dibra S.P.A. Procede de preparation de derives de l'acide 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylique
US5824821A (en) * 1997-02-07 1998-10-20 Nycomed Imaging As Process for the preparation of iodinated contrast agents and intermediates therefor
KR20000061780A (ko) * 1999-03-31 2000-10-25 강재헌 이오프로마이드의 제조방법

Also Published As

Publication number Publication date
EP2271615A1 (fr) 2011-01-12
KR101098553B1 (ko) 2011-12-26
EP2271615A4 (fr) 2014-05-21
CA2720752A1 (fr) 2009-11-05
JP2011518878A (ja) 2011-06-30
WO2009134030A1 (fr) 2009-11-05
KR20090114729A (ko) 2009-11-04
AU2009243319A1 (en) 2009-11-05
CN102015624A (zh) 2011-04-13
RU2451667C1 (ru) 2012-05-27
CA2720752C (fr) 2014-02-04
JP5156862B2 (ja) 2013-03-06
BRPI0911531A2 (pt) 2015-10-13
US20110034730A1 (en) 2011-02-10
CN102015624B (zh) 2013-11-06
US8420858B2 (en) 2013-04-16

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