AU2009224254A1 - Orally-disintegrating solid preparation - Google Patents
Orally-disintegrating solid preparation Download PDFInfo
- Publication number
- AU2009224254A1 AU2009224254A1 AU2009224254A AU2009224254A AU2009224254A1 AU 2009224254 A1 AU2009224254 A1 AU 2009224254A1 AU 2009224254 A AU2009224254 A AU 2009224254A AU 2009224254 A AU2009224254 A AU 2009224254A AU 2009224254 A1 AU2009224254 A1 AU 2009224254A1
- Authority
- AU
- Australia
- Prior art keywords
- fine granules
- preparation
- polymer
- coated
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
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Landscapes
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- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008-061673 | 2008-03-11 | ||
| JP2008061673 | 2008-03-11 | ||
| JP2008334920 | 2008-12-26 | ||
| JP2008-334920 | 2008-12-26 | ||
| PCT/JP2009/054983 WO2009113703A2 (en) | 2008-03-11 | 2009-03-10 | Orally-disintegrating solid preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2009224254A1 true AU2009224254A1 (en) | 2009-09-17 |
| AU2009224254A2 AU2009224254A2 (en) | 2010-11-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2009224254A Abandoned AU2009224254A1 (en) | 2008-03-11 | 2009-03-10 | Orally-disintegrating solid preparation |
Country Status (26)
| Country | Link |
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| EP (1) | EP2254556A2 (https=) |
| JP (1) | JP5604304B2 (https=) |
| KR (1) | KR20100129761A (https=) |
| CN (2) | CN102026627B (https=) |
| AR (1) | AR070863A1 (https=) |
| AU (1) | AU2009224254A1 (https=) |
| BR (1) | BRPI0909439A2 (https=) |
| CA (1) | CA2717947C (https=) |
| CL (1) | CL2009000557A1 (https=) |
| CO (1) | CO6321224A2 (https=) |
| CR (1) | CR11709A (https=) |
| DO (1) | DOP2010000273A (https=) |
| EA (1) | EA021792B1 (https=) |
| EC (1) | ECSP10010538A (https=) |
| GE (1) | GEP20135845B (https=) |
| IL (1) | IL207989A0 (https=) |
| MA (1) | MA32174B1 (https=) |
| MX (1) | MX2010009824A (https=) |
| MY (1) | MY173730A (https=) |
| NZ (1) | NZ588407A (https=) |
| PE (2) | PE20141034A1 (https=) |
| TW (1) | TWI441658B (https=) |
| UY (1) | UY31698A (https=) |
| WO (1) | WO2009113703A2 (https=) |
| ZA (1) | ZA201006679B (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI441658B (zh) | 2008-03-11 | 2014-06-21 | Takeda Pharmaceutical | 口腔崩解固體製劑 |
| RU2011102777A (ru) * | 2008-06-26 | 2012-08-10 | МакНЕЙЛ-ППС, ИНК. (US) | Частицы с покрытием, содержащие фармацевтически активные агенты |
| EP3031451B1 (en) * | 2009-01-26 | 2018-03-07 | Shin-Etsu Chemical Co., Ltd | Wet granulation tableting method using aqueous dispersion of low-substituted hydroxypropyl cellulose |
| EP2319504A1 (en) * | 2009-11-07 | 2011-05-11 | Laboratorios Del. Dr. Esteve, S.A. | Pharmaceutical solid dosage form |
| WO2012001705A2 (en) * | 2010-06-29 | 2012-01-05 | Cadila Healthcare Limited | Pharmaceutical compositions of (r)-lansoprazole |
| BR112013014875A2 (pt) * | 2010-12-27 | 2016-10-18 | Takeda Pharmaceutical | tablete oralmente desintegrável |
| CN102716097A (zh) * | 2012-05-29 | 2012-10-10 | 浙江华海药业股份有限公司 | 控制口腔崩解片药物释放速率的方法 |
| FI126168B (en) | 2012-09-18 | 2016-07-29 | Novaldmedical Ltd Oy | A method for coating pharmaceutical substrates |
| CA3042642A1 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| CA2955229C (en) | 2014-07-17 | 2020-03-10 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| WO2016064873A1 (en) | 2014-10-20 | 2016-04-28 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
| JP6371866B2 (ja) * | 2015-02-10 | 2018-08-08 | 富士フイルム株式会社 | 口腔内崩壊錠及びその製造方法 |
| WO2016174664A1 (en) | 2015-04-29 | 2016-11-03 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
| EP3419659A1 (en) | 2016-02-23 | 2019-01-02 | The Regents of the University of Colorado, A Body Corporate | Compositions and methods for making and using thermostable immunogenic formulations with increased compatibility of use as vaccines against one or more pathogens |
| EP3421032A4 (en) * | 2016-02-23 | 2019-10-23 | Nipro Corporation | PARTICULARS OF A PHARMACEUTICAL COMPOSITION, ORAL DECOMPOSITION PREPARATION THEREOF AND METHOD FOR PRODUCING PARTICLES OF A PHARMACEUTICAL COMPOSITION |
| GB201607548D0 (en) * | 2016-04-29 | 2016-06-15 | Univ Central Lancashire | Solid dosage form |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| JOP20190008A1 (ar) | 2016-07-26 | 2019-01-24 | Purdue Pharma Lp | علاج ومنع اضطرابات النوم |
| WO2018124284A1 (ja) * | 2016-12-28 | 2018-07-05 | 富山化学工業株式会社 | 医薬組成物 |
| PH12019500671B1 (en) * | 2017-02-21 | 2024-02-02 | Ea Pharma Co Ltd | Granular preparation |
| JP7235193B2 (ja) * | 2017-04-26 | 2023-03-08 | 大正製薬株式会社 | 固形組成物 |
| JP7009288B2 (ja) * | 2017-05-18 | 2022-01-25 | エルメッド株式会社 | 湿製錠剤の製造方法及び湿製錠剤の品質向上方法 |
| JP7336187B2 (ja) * | 2017-11-30 | 2023-08-31 | 日本ケミファ株式会社 | 多層構造を有する粒子状医薬組成物 |
| EP3740197A4 (en) | 2018-01-16 | 2021-11-10 | Applied Materials, Inc. | METAL OXIDE ENCAPSULATED COMPOSITIONS OF THE ACTIVE SUBSTANCE AND PROCESS FOR THEIR MANUFACTURING |
| KR20240160681A (ko) | 2018-01-24 | 2024-11-11 | 퍼듀 퍼머 엘피 | 수면 장애 치료 및 예방 |
| CN111836618A (zh) * | 2018-02-08 | 2020-10-27 | 景凱生物科技股份有限公司 | 类阿片受体拮抗剂的固体剂型用的医药剂型 |
| IL284564B2 (en) | 2019-01-31 | 2025-07-01 | Purdue Pharma Lp | Polymorphic forms of a substituted-quinoxaline-type bridged-piperidine compound |
| EP4021423A4 (en) | 2019-08-27 | 2023-11-08 | Applied Materials, Inc. | Vapor phase coating technology for pharmaceutical abuse deterrent formulations |
| KR20220051385A (ko) | 2019-08-27 | 2022-04-26 | 어플라이드 머티어리얼스, 인코포레이티드 | 약제 용해도 조절을 위한 증기상 코팅들 |
| GB202001237D0 (en) * | 2020-01-29 | 2020-03-11 | Sisteks D O O | Granular pharmaceutical product for oral administration from a pre-filled straw and method of manufacturing such pharmaceutical product |
| CA3168680A1 (en) | 2020-01-31 | 2021-08-05 | Nanocopoeia, Llc | Amorphous nilotinib microparticles and uses thereof |
| WO2021222739A1 (en) | 2020-04-30 | 2021-11-04 | Nanocopoeia, Llc | Orally disintegrating tablet comprising amorphous solid dispersion of nilotinib |
| TWI870622B (zh) | 2020-10-02 | 2025-01-21 | 美商應用材料股份有限公司 | 製備氧化矽塗佈藥品的低溫處理 |
| CN112121067A (zh) * | 2020-11-16 | 2020-12-25 | 深圳科兴药业有限公司 | 一种婴儿型双歧杆菌微胶囊及其制备方法 |
| CN116887866A (zh) | 2020-12-03 | 2023-10-13 | 巴特尔纪念研究院 | 聚合物纳米颗粒和dna纳米结构组合物及用于非病毒递送的方法 |
| WO2022216977A1 (en) | 2021-04-07 | 2022-10-13 | Batelle Memorial Institute | Rapid design, build, test, and learn technologies for identifying and using non-viral carriers |
| CN117750958A (zh) | 2021-05-21 | 2024-03-22 | 普渡制药公司 | 治疗间质性膀胱炎/膀胱疼痛综合征的方法 |
| EP4408402A4 (en) | 2021-09-30 | 2025-08-06 | Applied Materials Inc | LOW TEMPERATURE SILICON OXIDE COATING FOR PHARMACEUTICAL APPLICATIONS |
| WO2023182332A1 (ja) * | 2022-03-22 | 2023-09-28 | 株式会社ダイセル | 口腔内崩壊錠用の添加剤組成物 |
| WO2025072751A1 (en) | 2023-09-29 | 2025-04-03 | Battelle Memorial Institute | Polymer nanoparticle compositions for in vivo expression of polypeptides |
| AU2024364388A1 (en) | 2023-10-19 | 2026-03-19 | Purdue Pharma L.P. | Sunobinop for use in method of treating alcohol use disorder |
| CN117180213A (zh) * | 2023-10-23 | 2023-12-08 | 湖南洞庭药业股份有限公司 | 奥沙西泮片组合物及其制备和稳定化方法 |
| US12441996B2 (en) | 2023-12-08 | 2025-10-14 | Battelle Memorial Institute | Use of DNA origami nanostructures for molecular information based data storage systems |
| CN117860699A (zh) * | 2024-01-07 | 2024-04-12 | 长沙晶易医药科技股份有限公司 | 一种细粒剂及其制备方法 |
| KR20260019740A (ko) * | 2024-08-02 | 2026-02-10 | 일양약품주식회사 | 일라프라졸, 제산제 및 알칼리화제를 포함하는 안정한 약제학적 조성물 및 이의 제조방법 |
| US12303604B1 (en) | 2024-10-16 | 2025-05-20 | Currax Pharmaceuticals Llc | Pharmaceutical formulations comprising naltrexone and/or bupropion |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62277322A (ja) | 1986-02-13 | 1987-12-02 | Takeda Chem Ind Ltd | 安定化された腸溶性抗潰瘍固形組成物 |
| CA1327010C (en) | 1986-02-13 | 1994-02-15 | Tadashi Makino | Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production |
| FR2679451B1 (fr) | 1991-07-22 | 1994-09-09 | Prographarm Laboratoires | Comprime multiparticulaire a delitement rapide. |
| US5464632C1 (en) * | 1991-07-22 | 2001-02-20 | Prographarm Lab | Rapidly disintegratable multiparticular tablet |
| SE9402431D0 (sv) | 1994-07-08 | 1994-07-08 | Astra Ab | New tablet formulation |
| US6024981A (en) | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
| US6096340A (en) | 1997-11-14 | 2000-08-01 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
| DK2263660T3 (en) | 1998-05-18 | 2018-01-02 | Takeda Pharmaceuticals Co | Orally disintegrating tablets. |
| ATE291418T1 (de) | 1998-07-28 | 2005-04-15 | Takeda Pharmaceutical | Leicht zerfallende feste zubereitung |
| WO2000018374A1 (en) | 1998-10-01 | 2000-04-06 | Elan Pharma International, Ltd. | Controlled release nanoparticulate compositions |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| TWI289557B (en) * | 1999-06-17 | 2007-11-11 | Takeda Chemical Industries Ltd | A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole |
| GB0025208D0 (en) | 2000-10-13 | 2000-11-29 | Euro Celtique Sa | Delayed release pharmaceutical formulations |
| SK287902B6 (sk) * | 2001-01-31 | 2012-03-02 | Evonik Rohm Gmbh | Multiparticulate drug form and method for the preparation thereof |
| BR0211117A (pt) * | 2001-07-16 | 2004-06-22 | Astrazeneca Ab | Tablete multiparticulado, processo para a manufatura e uso do mesmo, e, método e tratamento de distúrbios gastrointestinais |
| DE10208335A1 (de) | 2002-02-27 | 2003-09-04 | Roehm Gmbh | Arzneiform und Verfahren zu ihrer Herstellung |
| AUPS167602A0 (en) | 2002-04-12 | 2002-05-16 | F.H. Faulding & Co. Limited | An improved modified release preparation |
| MY148805A (en) | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
| JP4493970B2 (ja) | 2002-10-16 | 2010-06-30 | 武田薬品工業株式会社 | 持続性製剤 |
| US20040096497A1 (en) | 2002-11-19 | 2004-05-20 | Ponder Garratt W. | Methods of providing controlled-release pharmaceutical compositions and controlled-release pharmaceutical compositions |
| MXPA04010956A (es) * | 2003-01-30 | 2005-01-25 | Roehm Gmbh | Forma de dosis farmaceutica y metodo para la produccion de la misma. |
| US20060115529A1 (en) * | 2003-05-07 | 2006-06-01 | Seonghoon Jeong | Fast-melting tablets having taste-masking and sustained release properties |
| WO2005009410A2 (en) | 2003-07-17 | 2005-02-03 | Dr. Reddy's Laboratories, Inc. | Pharmaceutical compositions having a swellable coating |
| JP2007506775A (ja) | 2003-09-26 | 2007-03-22 | アルザ・コーポレーシヨン | 漸増する放出速度を表す制御放出製剤 |
| GB0323232D0 (en) * | 2003-10-03 | 2003-11-05 | Rolls Royce Plc | Electrical machine |
| EP1750717B1 (en) | 2004-02-11 | 2017-07-19 | Rubicon Research Private Limited | Controlled release pharmaceutical compositions with improved bioavailability |
| US20050181052A1 (en) | 2004-02-17 | 2005-08-18 | Patel Satishkumar A. | Lansoprazole microtablets |
| US20050214372A1 (en) | 2004-03-03 | 2005-09-29 | Simona Di Capua | Stable pharmaceutical composition comprising an acid labile drug |
| CA2557634A1 (en) | 2004-03-04 | 2005-09-15 | Takeda Pharmaceutical Company Limited | Stable capsule preparation |
| US8545881B2 (en) * | 2004-04-19 | 2013-10-01 | Eurand Pharmaceuticals, Ltd. | Orally disintegrating tablets and methods of manufacture |
| CA2579767A1 (en) * | 2004-04-30 | 2005-11-10 | Astellas Pharma Inc. | Oral pharmaceutical composition in timed-release particle form and fast-disintegrating tablets containing this composition |
| DE102004035936A1 (de) | 2004-07-23 | 2006-03-16 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform |
| US20080063710A1 (en) | 2004-12-28 | 2008-03-13 | Eisai R&D Management Co., Ltd. | Rapidly Disintegrating Tablet and Production Method Thereof |
| GB0502479D0 (en) | 2005-02-07 | 2005-03-16 | Sb Pharmco Inc | Novel compositions |
| FR2885526B1 (fr) * | 2005-05-13 | 2007-07-27 | Flamel Technologies Sa | Medicament oral a base d'inhibiteur de pompe a protons |
| DE102005024614A1 (de) * | 2005-05-25 | 2006-11-30 | Röhm Gmbh | Verwendung von Polymermischungen zur Herstellung von überzogenen Arzneiformen sowie Arzneiform mit polymerem Mischüberzug |
| WO2006105798A2 (en) | 2005-07-11 | 2006-10-12 | Nycomed Danmark Aps | Benzimidazole formulation |
| DE102005032806A1 (de) * | 2005-07-12 | 2007-01-18 | Röhm Gmbh | Verwendung eines teilneutralisierten, anionischen (Meth)acrylat-Copolymers als Überzug für die Herstellung einer Arzneiform mit einer Wirkstofffreisetzung bei erniedrigten pH-Werten |
| WO2007037259A1 (ja) | 2005-09-29 | 2007-04-05 | Eisai R & D Management Co., Ltd. | 生体内での崩壊性を向上させたパルス製剤 |
| FR2891459B1 (fr) * | 2005-09-30 | 2007-12-28 | Flamel Technologies Sa | Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant |
| US20070141151A1 (en) * | 2005-12-20 | 2007-06-21 | Silver David I | Lansoprazole orally disintegrating tablets |
| JP2009519334A (ja) | 2005-12-20 | 2009-05-14 | テバ ファーマシューティカル インダストリーズ リミティド | ランソプラゾール経口崩壊錠剤 |
| EP1813275A1 (en) * | 2005-12-20 | 2007-08-01 | Teva Pharmaceutical Industries Ltd | Lansoprazole orally disintegrating tablets |
| EP1962844A2 (en) | 2005-12-20 | 2008-09-03 | Teva Pharmaceutical Industries Ltd | Lansoprazole orally disintegrating tablets |
| US8486450B2 (en) | 2005-12-28 | 2013-07-16 | Takeda Pharmaceutical Company Limited | Method of producing solid preparation disintegrating in the oral cavity |
| KR100762847B1 (ko) | 2006-01-27 | 2007-10-04 | 씨제이 주식회사 | 멀티플 유닛 타입 서방성 경구 제제 및 그 제조방법 |
| EP1837016A3 (en) | 2006-03-08 | 2008-01-02 | KRKA, tovarna zdravil, d.d., Novo mesto | Pharmaceutical multiple-unit composition |
| WO2007122478A2 (en) | 2006-04-20 | 2007-11-01 | Themis Laboratories Private Limited | Multiple unit compositions |
| NZ703464A (en) | 2006-04-26 | 2016-05-27 | Alphapharm Pty Ltd | Controlled release formulations comprising uncoated discrete unit(s) and an extended release matrix |
| ES2466441T3 (es) | 2006-04-28 | 2014-06-10 | Wockhardt Limited | Composiciones farmacéuticas que comprenden fármaco antiinflamatorio no esteroideo, acetaminofén e inhibidor de la bomba de protones |
| KR20090038431A (ko) | 2006-06-19 | 2009-04-20 | 맥네일-피피씨, 인코포레이티드 | 활성 성분을 함유하는 장용 피복된 입자 |
| US20090291136A1 (en) | 2006-07-11 | 2009-11-26 | Lek Pharmaceuticals D.D. | Multiple Unit Tablets |
| US20090252787A1 (en) | 2006-07-28 | 2009-10-08 | Dr. Reddy's Laboratories Ltd. | Granular pharmaceutical compositions |
| KR101575679B1 (ko) | 2006-08-30 | 2015-12-08 | 자고텍 아게 | 코어 및 하나 이상의 배리어 층을 포함하는 방출 제어형 경구 투여 제제 |
| US9486446B2 (en) | 2006-12-28 | 2016-11-08 | Takeda Pharmaceutical Company Limited | Orally disintegrating solid preparation |
| DE102007009242A1 (de) * | 2007-02-22 | 2008-09-18 | Evonik Röhm Gmbh | Pellets mit magensaftresistenter Wirkstoff-Matix |
| DE102007009243A1 (de) * | 2007-02-22 | 2008-09-18 | Evonik Röhm Gmbh | Pellets mit einer Wirkstoff-Matrix und einem Polymerüberzug, sowie ein Verfahren zur Herstellung der Pellets |
| CA2687130C (en) | 2007-05-07 | 2017-10-03 | Evonik Roehm Gmbh | Solid dosage forms comprising an enteric coating with accelerated drug release |
| TWI441658B (zh) | 2008-03-11 | 2014-06-21 | Takeda Pharmaceutical | 口腔崩解固體製劑 |
| WO2010008569A1 (en) | 2008-07-17 | 2010-01-21 | Barr Laboratories, Inc. | Orally disintegrating solid pharmaceutical dosage forms comprising delayed-release lansoprazole and methods of making and using the same |
| BR112013014875A2 (pt) | 2010-12-27 | 2016-10-18 | Takeda Pharmaceutical | tablete oralmente desintegrável |
-
2009
- 2009-03-10 TW TW098107630A patent/TWI441658B/zh not_active IP Right Cessation
- 2009-03-10 BR BRPI0909439A patent/BRPI0909439A2/pt not_active Application Discontinuation
- 2009-03-10 EP EP09720410A patent/EP2254556A2/en not_active Withdrawn
- 2009-03-10 NZ NZ588407A patent/NZ588407A/en not_active IP Right Cessation
- 2009-03-10 EA EA201071054A patent/EA021792B1/ru not_active IP Right Cessation
- 2009-03-10 JP JP2010536259A patent/JP5604304B2/ja not_active Expired - Fee Related
- 2009-03-10 AR ARP090100842A patent/AR070863A1/es unknown
- 2009-03-10 WO PCT/JP2009/054983 patent/WO2009113703A2/en not_active Ceased
- 2009-03-10 GE GEAP2009011969 patent/GEP20135845B/en unknown
- 2009-03-10 AU AU2009224254A patent/AU2009224254A1/en not_active Abandoned
- 2009-03-10 CA CA2717947A patent/CA2717947C/en active Active
- 2009-03-10 KR KR1020107022551A patent/KR20100129761A/ko not_active Ceased
- 2009-03-10 CL CL2009000557A patent/CL2009000557A1/es unknown
- 2009-03-10 MY MYPI2010004253A patent/MY173730A/en unknown
- 2009-03-10 CN CN200980116971.XA patent/CN102026627B/zh not_active Expired - Fee Related
- 2009-03-10 US US12/921,731 patent/US9241910B2/en active Active
- 2009-03-10 UY UY0001031698A patent/UY31698A/es not_active Application Discontinuation
- 2009-03-10 PE PE2014000364A patent/PE20141034A1/es not_active Application Discontinuation
- 2009-03-10 PE PE2009000349A patent/PE20091620A1/es not_active Application Discontinuation
- 2009-03-10 CN CN201410370293.2A patent/CN104127368A/zh active Pending
- 2009-03-10 MX MX2010009824A patent/MX2010009824A/es not_active Application Discontinuation
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2010
- 2010-09-05 IL IL207989A patent/IL207989A0/en unknown
- 2010-09-10 DO DO2010000273A patent/DOP2010000273A/es unknown
- 2010-09-17 ZA ZA2010/06679A patent/ZA201006679B/en unknown
- 2010-09-29 MA MA33210A patent/MA32174B1/fr unknown
- 2010-09-30 CR CR11709A patent/CR11709A/es unknown
- 2010-10-11 CO CO10125889A patent/CO6321224A2/es not_active Application Discontinuation
- 2010-10-11 EC EC2010010538A patent/ECSP10010538A/es unknown
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2014
- 2014-10-21 US US14/519,979 patent/US20150037423A1/en not_active Abandoned
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