AU2009204464B2 - Therapeutic inhibitors of PAI-1 function and methods of their use - Google Patents
Therapeutic inhibitors of PAI-1 function and methods of their use Download PDFInfo
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- AU2009204464B2 AU2009204464B2 AU2009204464A AU2009204464A AU2009204464B2 AU 2009204464 B2 AU2009204464 B2 AU 2009204464B2 AU 2009204464 A AU2009204464 A AU 2009204464A AU 2009204464 A AU2009204464 A AU 2009204464A AU 2009204464 B2 AU2009204464 B2 AU 2009204464B2
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- C12Y304/21069—Protein C activated (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2013708P | 2008-01-09 | 2008-01-09 | |
| US61/020,137 | 2008-01-09 | ||
| US8064008P | 2008-07-14 | 2008-07-14 | |
| US61/080,640 | 2008-07-14 | ||
| PCT/US2009/000155 WO2009089059A2 (en) | 2008-01-09 | 2009-01-09 | Therapeutic inhibitors of pai-1 function methods of their use |
Publications (2)
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| AU2009204464A1 AU2009204464A1 (en) | 2009-07-16 |
| AU2009204464B2 true AU2009204464B2 (en) | 2014-12-04 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2009204464A Ceased AU2009204464B2 (en) | 2008-01-09 | 2009-01-09 | Therapeutic inhibitors of PAI-1 function and methods of their use |
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| US (2) | US8431363B2 (enExample) |
| EP (1) | EP2242501A4 (enExample) |
| JP (2) | JP2011509093A (enExample) |
| KR (1) | KR101712208B1 (enExample) |
| CN (1) | CN102123721A (enExample) |
| AU (1) | AU2009204464B2 (enExample) |
| BR (1) | BRPI0906867A2 (enExample) |
| CA (1) | CA2711878A1 (enExample) |
| IL (1) | IL206891A0 (enExample) |
| MX (1) | MX2010007586A (enExample) |
| RU (1) | RU2010133847A (enExample) |
| WO (1) | WO2009089059A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| BRPI0906867A2 (pt) | 2008-01-09 | 2019-09-24 | Intrexon Corp | inibidores terapêuticos da função pai-1 e métodos de uso dos mesmo |
| NZ603482A (en) * | 2010-05-12 | 2014-11-28 | Tengion Inc | Bioactive renal cells |
| WO2013164970A1 (ja) * | 2012-05-01 | 2013-11-07 | 富士フイルム株式会社 | 多能性幹細胞の培養方法及びこれに用いるポリペプチド |
| CN103421781B (zh) * | 2012-07-04 | 2014-12-31 | 华中农业大学 | 猪肌肉组织特异性表达基因myf6启动子及应用 |
| EP3080156A1 (en) * | 2013-12-10 | 2016-10-19 | F. Hoffmann-La Roche AG | Use of the binding domain of a subunit of a multi-subunit structure for targeted delivery of pharmaceutically active entities to the multi-subunit structure |
| CN110167583A (zh) * | 2016-12-15 | 2019-08-23 | 泰伦基国际有限公司 | 一种治疗冠状动脉粥样硬化及其并发症的方法 |
| CN110114081A (zh) | 2016-12-15 | 2019-08-09 | 泰伦基国际有限公司 | 一种改善心脏病变的方法 |
| JP7168990B2 (ja) | 2016-12-15 | 2022-11-10 | タレンゲン インターナショナル リミテッド | 肥満症を予防および治療するための方法および薬物 |
| US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
| EP3902913A1 (en) | 2018-12-28 | 2021-11-03 | Catalyst Biosciences, Inc. | Modified urokinase-type plasminogen activator polypeptides and methods of use |
| CN119656313A (zh) * | 2024-12-13 | 2025-03-21 | 四川大学华西医院 | Serpine1基因作为靶点在制备预防或治疗心肌纤维化药物中的用途 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639726A (en) * | 1994-09-30 | 1997-06-17 | The Regents Of The University Of Michigan | Peptide mediated enhancement of thrombolysis methods and compositions |
| DE10053251A1 (de) * | 2000-10-26 | 2002-05-08 | Boehringer Ingelheim Pharma | Epitope von PAI-1 |
| WO2003095476A2 (en) * | 2002-05-08 | 2003-11-20 | Thrombotech Ltd. | PEPTIDES FOR REGULATION OF UROKINASE (uPA) AND TISSUE TYPE (tPA) PLASMINOGEN ACTIVATOR AND METHOD OF OPTIMIZING THERAPEUTIC EFFICACY |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001024815A1 (en) | 1999-10-07 | 2001-04-12 | Human Genome Sciences, Inc. | Plasminogen-like polynucleotides, polypeptides, and antibodies |
| US20030199463A1 (en) * | 2002-04-23 | 2003-10-23 | Silviu Itescu | DNA enzyme to inhibit plasminogen activator inhibitor-1 |
| CN1668312A (zh) * | 2002-05-13 | 2005-09-14 | 洛杉矶儿童医院 | 疤痕疙瘩和其它的皮肤或内部的创伤或损伤中异常疤痕形成的处理和抑制 |
| US7241613B1 (en) | 2002-06-05 | 2007-07-10 | Oscient Pharmaceuticals Corporation | Identification of Candida cell surface proteins and their uses |
| US7785871B2 (en) | 2002-10-09 | 2010-08-31 | Intrexon Corporation | DNA cloning vector plasmids and methods for their use |
| US20080050808A1 (en) | 2002-10-09 | 2008-02-28 | Reed Thomas D | DNA modular cloning vector plasmids and methods for their use |
| US7071295B2 (en) | 2002-12-02 | 2006-07-04 | Intrexon Corporation | Signal for targeting molecules to the sarco(endo)plasmic reticulum |
| BR0316584A (pt) | 2002-12-10 | 2005-10-04 | Wyeth Corp | Derivados de ácido acético indol oxo-acetil amino substituìdo como inibidores do inibidor-1 do ativador do plasminogênio (pai-1) |
| ES2603062T3 (es) | 2004-05-18 | 2017-02-23 | Intrexon Corporation | Métodos de ensamblaje dinámico de vectores para la clonación de ADN de vectores plasmídicos |
| US8153598B2 (en) | 2005-10-19 | 2012-04-10 | Intrexon Corporation | PKD ligands and polynucleotides encoding PKD ligands |
| WO2007048103A2 (en) | 2006-10-18 | 2007-04-26 | Intrexon Corporation | Pkd ligands and polynucleotides encoding pkd ligands |
| US7943732B2 (en) | 2006-06-05 | 2011-05-17 | Intrexon Corporation | AKT ligands and polynucleotides encoding AKT ligands |
| US8993263B2 (en) | 2006-08-07 | 2015-03-31 | Intrexon Corporation | PKA ligands and polynucleotides encoding PKA ligands |
| US8999666B2 (en) | 2006-08-09 | 2015-04-07 | Intrexon Corporation | PKC ligands and polynucleotides encoding PKC ligands |
| US8729225B2 (en) | 2006-11-13 | 2014-05-20 | Intrexon Corporation | Glycogen synthase kinase heteropolyligand polypeptide |
| US8283445B2 (en) | 2006-11-13 | 2012-10-09 | Intrexon Corporation | Extracellular-signal-regulated-kinase (ERK) heteropolyligand polypeptide |
| US7705122B2 (en) | 2006-12-04 | 2010-04-27 | Intrexon Corporation | mTOR ligands and polynucleotides encoding mTOR ligands |
| CA2680837C (en) | 2007-03-27 | 2017-06-06 | Intrexon Corporation | Mek ligands and polynucleotides encoding mek ligands |
| EP2150273A4 (en) * | 2007-04-27 | 2010-11-17 | Univ Toledo | MODIFIED PLASMINOGEN ACTIVATOR INHIBITOR MOLECULE AND METHODS OF USE |
| BRPI0906867A2 (pt) | 2008-01-09 | 2019-09-24 | Intrexon Corp | inibidores terapêuticos da função pai-1 e métodos de uso dos mesmo |
-
2009
- 2009-01-09 BR BRPI0906867A patent/BRPI0906867A2/pt not_active IP Right Cessation
- 2009-01-09 US US12/812,127 patent/US8431363B2/en not_active Expired - Fee Related
- 2009-01-09 MX MX2010007586A patent/MX2010007586A/es active IP Right Grant
- 2009-01-09 CA CA2711878A patent/CA2711878A1/en not_active Abandoned
- 2009-01-09 EP EP09700772A patent/EP2242501A4/en not_active Withdrawn
- 2009-01-09 CN CN2009801088638A patent/CN102123721A/zh active Pending
- 2009-01-09 JP JP2010542283A patent/JP2011509093A/ja not_active Withdrawn
- 2009-01-09 AU AU2009204464A patent/AU2009204464B2/en not_active Ceased
- 2009-01-09 WO PCT/US2009/000155 patent/WO2009089059A2/en not_active Ceased
- 2009-01-09 RU RU2010133847/10A patent/RU2010133847A/ru not_active Application Discontinuation
- 2009-01-09 KR KR1020107017701A patent/KR101712208B1/ko not_active Expired - Fee Related
-
2010
- 2010-07-08 IL IL206891A patent/IL206891A0/en unknown
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2012
- 2012-01-18 JP JP2012008069A patent/JP2012135307A/ja not_active Withdrawn
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2013
- 2013-02-15 US US13/769,144 patent/US8828686B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639726A (en) * | 1994-09-30 | 1997-06-17 | The Regents Of The University Of Michigan | Peptide mediated enhancement of thrombolysis methods and compositions |
| DE10053251A1 (de) * | 2000-10-26 | 2002-05-08 | Boehringer Ingelheim Pharma | Epitope von PAI-1 |
| WO2003095476A2 (en) * | 2002-05-08 | 2003-11-20 | Thrombotech Ltd. | PEPTIDES FOR REGULATION OF UROKINASE (uPA) AND TISSUE TYPE (tPA) PLASMINOGEN ACTIVATOR AND METHOD OF OPTIMIZING THERAPEUTIC EFFICACY |
Non-Patent Citations (1)
| Title |
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| Eitzman, D.T et al, The Journal of Clinical Investigation (1995), Volume 95, pages 2416-2420. * |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2010007586A (es) | 2011-02-22 |
| US8828686B2 (en) | 2014-09-09 |
| KR20100129271A (ko) | 2010-12-08 |
| KR101712208B1 (ko) | 2017-03-03 |
| AU2009204464A1 (en) | 2009-07-16 |
| WO2009089059A3 (en) | 2009-09-24 |
| US20110055940A1 (en) | 2011-03-03 |
| WO2009089059A2 (en) | 2009-07-16 |
| RU2010133847A (ru) | 2012-05-20 |
| US8431363B2 (en) | 2013-04-30 |
| US20130267022A1 (en) | 2013-10-10 |
| JP2011509093A (ja) | 2011-03-24 |
| CN102123721A (zh) | 2011-07-13 |
| EP2242501A2 (en) | 2010-10-27 |
| EP2242501A4 (en) | 2011-10-19 |
| BRPI0906867A2 (pt) | 2019-09-24 |
| IL206891A0 (en) | 2010-12-30 |
| JP2012135307A (ja) | 2012-07-19 |
| CA2711878A1 (en) | 2009-07-16 |
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