AU2008240119B2 - Diazo bicyclic Smac mimetics and the uses thereof - Google Patents

Diazo bicyclic Smac mimetics and the uses thereof Download PDF

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Publication number
AU2008240119B2
AU2008240119B2 AU2008240119A AU2008240119A AU2008240119B2 AU 2008240119 B2 AU2008240119 B2 AU 2008240119B2 AU 2008240119 A AU2008240119 A AU 2008240119A AU 2008240119 A AU2008240119 A AU 2008240119A AU 2008240119 B2 AU2008240119 B2 AU 2008240119B2
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Prior art keywords
compound
optionally substituted
formula
cancer
pct
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AU2008240119A
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AU2008240119A1 (en
Inventor
Qian Cai
Jianfeng Lu
Zaneta Nikolovska-Coleska
Yuefeng Peng
Su Qiu
Haiying Sun
Shaomeng Wang
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University of Michigan System
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University of Michigan System
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Application filed by University of Michigan System filed Critical University of Michigan System
Publication of AU2008240119A1 publication Critical patent/AU2008240119A1/en
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Publication of AU2008240119B2 publication Critical patent/AU2008240119B2/en
Ceased legal-status Critical Current
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
AU2008240119A 2007-04-13 2008-04-14 Diazo bicyclic Smac mimetics and the uses thereof Ceased AU2008240119B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92334807P 2007-04-13 2007-04-13
US60/923,348 2007-04-13
PCT/US2008/060215 WO2008128171A2 (en) 2007-04-13 2008-04-14 Diazo bicyclic smac mimetics and the uses thereof

Publications (2)

Publication Number Publication Date
AU2008240119A1 AU2008240119A1 (en) 2008-10-23
AU2008240119B2 true AU2008240119B2 (en) 2012-04-05

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ID=39864640

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AU2008240119A Ceased AU2008240119B2 (en) 2007-04-13 2008-04-14 Diazo bicyclic Smac mimetics and the uses thereof

Country Status (22)

Country Link
US (2) US8278293B2 (OSRAM)
EP (1) EP2139490B1 (OSRAM)
JP (1) JP5416089B2 (OSRAM)
KR (1) KR101081685B1 (OSRAM)
CN (1) CN101686981B (OSRAM)
AU (1) AU2008240119B2 (OSRAM)
BR (1) BRPI0810522B8 (OSRAM)
CA (1) CA2683318C (OSRAM)
CY (1) CY1115735T1 (OSRAM)
DK (1) DK2139490T3 (OSRAM)
EA (1) EA017797B1 (OSRAM)
ES (1) ES2504216T3 (OSRAM)
HR (1) HRP20140885T1 (OSRAM)
HU (1) HUE024142T2 (OSRAM)
IL (1) IL201474A (OSRAM)
MX (1) MX2009011069A (OSRAM)
NZ (1) NZ580468A (OSRAM)
PL (1) PL2139490T3 (OSRAM)
PT (1) PT2139490E (OSRAM)
SI (1) SI2139490T1 (OSRAM)
WO (1) WO2008128171A2 (OSRAM)
ZA (1) ZA200907055B (OSRAM)

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TWI543988B (zh) 2006-03-16 2016-08-01 科學製藥股份有限公司 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物
EP2139490B1 (en) * 2007-04-13 2014-07-02 The Regents of the University of Michigan Diazo bicyclic smac mimetics and the uses thereof
US8815927B2 (en) 2009-10-23 2014-08-26 The Regents Of The University Of Michigan Bivalent diazo bicyclic Smac mimetics and the uses thereof
EP2496606A2 (en) 2009-11-05 2012-09-12 The UAB Research Foundation Treating basal-like genotype cancers
KR20120140658A (ko) 2010-02-12 2012-12-31 파마사이언스 인크. Ｉａｐ ｂｉｒ 도메인 결합 화합물
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Also Published As

Publication number Publication date
US20120309961A1 (en) 2012-12-06
BRPI0810522B1 (pt) 2020-02-04
US8278293B2 (en) 2012-10-02
PT2139490E (pt) 2014-10-08
DK2139490T3 (da) 2014-09-08
JP5416089B2 (ja) 2014-02-12
AU2008240119A1 (en) 2008-10-23
CN101686981A (zh) 2010-03-31
NZ580468A (en) 2012-02-24
EP2139490B1 (en) 2014-07-02
SI2139490T1 (sl) 2014-11-28
ZA200907055B (en) 2011-03-30
WO2008128171A3 (en) 2008-12-11
CN101686981B (zh) 2013-04-10
BRPI0810522A2 (pt) 2014-10-21
PL2139490T3 (pl) 2014-11-28
EP2139490A4 (en) 2010-10-27
KR20100005213A (ko) 2010-01-14
IL201474A0 (en) 2010-05-31
HUE024142T2 (en) 2016-02-29
IL201474A (en) 2015-11-30
US8664212B2 (en) 2014-03-04
JP2010523722A (ja) 2010-07-15
ES2504216T3 (es) 2014-10-08
BRPI0810522B8 (pt) 2021-05-25
EA017797B1 (ru) 2013-03-29
CA2683318A1 (en) 2008-10-23
WO2008128171A2 (en) 2008-10-23
HRP20140885T1 (hr) 2014-11-21
CA2683318C (en) 2012-10-30
US20100273812A1 (en) 2010-10-28
EA200901400A1 (ru) 2010-04-30
HK1141456A1 (en) 2010-11-12
CY1115735T1 (el) 2017-01-25
KR101081685B1 (ko) 2011-11-09
MX2009011069A (es) 2009-12-03
EP2139490A2 (en) 2010-01-06

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